雌孕激素联合补充治疗与脑卒中的预防

目的　探讨低剂量雌孕激素联合补充治疗对脑卒中的预防作用。方法　绝经过渡期及绝经后妇女84例随机设激素补充治疗组和对照组 ,采用酶免法测定治疗前后血脂和雌二醇 (E2 )水平。结果　治疗前后 E2、高密度脂蛋白 (HDL)增高 ,低密度脂蛋白 (L DL)、总胆固醇 (TC)降低 ,差异显著 (P<0 .0 5 ) ,甘油三酯 (TG)变化不明显。结论　低剂量雌激素对血脂谱产生有利影响 ,可降低脑卒中的发生     

Elevations of neuropeptide Y-like immunoreactivity and catecholamines in plasma on increased intracranial pressure in the pig

Graded increases of intracranial pressure (ICP) in anaesthetized pigs induced elevations of plasma levels of neuropeptide Y (NPY)-like immunoreactivity (LI) and catecholamines, simultaneously with hypertension and tachycardia. Plasma adrenaline (ADR) increased at a lower ICP-level than did the plasma levels of noradrenaline (NA) and NPY-LI. At the maximal ICP elevation, 22.9 kPa (172 mmHg), plasma NPY-LI was increased about 10-fold, from 48 +/- 8 pmol/l in the basal state, while NA and ADR concentrations increased more than 100-fold. At this maximal ICP-level the plasma levels of NPY-LI were correlated to the concentrations of both NA (r = 0.87, P less than 0.01) and ADR (r = 0.92, P less than 0.001). Plasma NPY-LI continued to increase to about 1000 pmol/l, 10 min after the maximal elevation of ICP was discontinued, while the catecholamines then had declined considerably. A slight cardiac release of NPY-LI was observed at the maximal elevation of ICP. The half-life of NPY-LI in plasma was about 6 min upon systemic infusion. At plasma levels similar to those obtained upon maximal ICP elevation, exogenous NPY caused slight vasoconstriction in the spleen and skeletal muscle, but had no effects on coronary blood flow or systemic blood pressure. This suggests that NPY mainly exerts local actions after release from nerve endings, while levels of circulating NPY in plasma must be very high to influence blood flow in some organs. It is concluded that elevation of ICP results in hypertension and tachycardia related to elevated plasma levels of NPY-LI and catecholamines.(ABSTRACT TRUNCATED AT 250 WORDS)     

N—酰化壳聚糖膜性能的研究

讨论了一系列N-酰化壳聚糖膜的抗张强度、透水性、VB_(12)的透过性、透氧性以及血液相容性。N-已酰化壳聚糖膜具有良好的血液相容性。在制膜过程中,加入分子量为1500的聚乙二醇为致孔剂,则可使N-己酰化壳聚糖膜的渗透性有较大提高。同时保持较好的血液相容性和强度。     

Stimulation-induced setting of postural muscle tone in the decerebrate rat

These studies demonstrate the presence of pontomedullary areas in the rat brainstem which, when stimulated electrically, serve to set postural muscle tone in the hindlimbs. Low amplitude stimulation of the dorsal tegmental field (DTF) was found to inhibit postural muscle tone and, in some rats, was found to decrease mean arterial pressure. Low amplitude stimulation of the ventral tegmental field (VTF) was found to increase postural muscle tone and, in all cases tested, was found to increase mean arterial pressure.     

卡介苗对哮喘豚鼠的影响

目的 研究卡介苗对哮喘豚鼠的防治作用。方法 24只豚鼠随机分为阳性对照组、地塞米松组、卡介苗组及阴性对照组,每组6只,除阴性对照组用生理盐水外,其余三组每只腹腔内注射鸡卵蛋白100mg,2周后用1％鸡卵蛋白激发致敏,每次30min,每日1次,持续3d,地塞米松组每次激发前肌注地塞米松2mg/kg,卡介苗组每次激发前肌往卡介苗30mg/kg,阳性对照组每次激发前30min肌注生理盐水2ml,最后用乌拉坦麻醉,检验动脉血气分析参数,嗜酸粒细胞(EOS)计数等参数,所有参数用t检验或卡方检验分析。结果 阳性对照组与其它三组比较,在豚鼠的发病程度、动脉血气分析、外周血EOS计数、支气管肺泡灌洗液中EOS计数、支气管病理切片每20个高倍视野EOS计数均有明显差异(P<0.05或P<0.01)。结论 卡介苗能够抑制动物模型中的哮喘反应。     

维生素E对高脂血症的影响

本文报道用高脂饲料造成家兔高脂血症的研究。经6周后,测定血脂、脂蛋白及血浆假胆硷脂酶等项指标,高脂组各项指标均明显高于对照组,但高脂加维生素E组的各项指标均低于高脂组,结果说明维生素E能降低兔的高脂血症。     

老年人高粘滞血症预防的初步探讨

本文报告对32例60岁以上健康老年人预防高粘滞血症的观察结果.经采取综合预防措施六年,血流变学检测表明:全血(比)粘度、血浆(比)粘度、血沉、红细胞压积均低于对照组,统计学处理表明,前三项指标P值均小于0.01,因此达到了对老年人高粘滞血症的预防目的.     

Possible Role of Streptococcus Pyogenes in Mucocutaneous Lymph Node Syndrome. XII. Variable Responses of Platelets in MCLS Seem to Be Explainable by Streptococcal Pyrogenic Exotoxin

As a model system for mucocutaneous lymph node syndrome (MCLS), we have advocated and used mice which had been rendered tolerant to Streptococcus pyogenes-associated antigens by neonatal infection with group A fteta-hemolytic streptococci, because these mice have shown a variety of peculiar bioimmunological characteristics bearing a striking resemblance to those of MCLS patients. The results of our current investigations reaffirmed the reliability of the animal model by indicating that mice subjected to neonatal infection with 5. pyogenes , or inoculation with streptococcal pyrogenic exotoxin (SPE) in Freund's adjuvant, were perfect counterparts of patients with MCLS on account of their platelet activation and hyperaggregability in response to provocative treatment, which are familiar findings in this disease.     

In vivo comparison of two through-plane MR velocity mapping methods: Fast fourier encoding and phase mapping

Magnetic resonance imaging maps of velocity were acquired with a 1.5-T system in 10 subjects in a plane perpendicular to the main pulmonary artery. Velocity images were successively acquired with a method developed from Fourier-encoding velocity imaging (FEVI) principles with eight gradient steps and one excitation, and with two-point phase-subtraction mapping. Reconstruction in FEVI was implemented by zero-filling interpolation around the eight gradient steps and then around the four central steps. The methods were compared by using estimates of noise in velocity measurements based on the difference between the experimental map and a smooth fitted map. For the same acquisition time, FEVI with four encoding steps was more precise in velocity measurements than phase mapping. Precision was further increased by the use of eight encoding steps, but acquisition time was doubled.     

血康口服液与他莫昔芬联合治疗免疫性血小板减少性紫癜疗效观察

联合应用血康口服液和他莫昔芬治疗成人免疫性血小板减少性紫癜(ITP)20例。疗程超过2月。15例患者的血小板(BPC)计数明显上升,有效率为75％(15/20),对于激素治疗无效者,仍有良效。对月经过多者和不适合应用激素者尤为适应。两药合用无明显副作用。治疗起效时间较快,平均13天。疗效持续时间较长,长者已达一年以上。