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71.
Simon McHugh John Deighton Ian Rifkin Pamela Ewan 《European journal of immunology》1996,26(6):1260-1265
The importance of cytokine production in some disease processes is now widely recognized. To investigate temporal relationships between cytokines, we stimulated peripheral blood mononuclear cells (PBMC) in vitro using the T cell mitogen phytohemagglutinin (PHA) and various antigens chosen to induce predominantly Th1 (streptokinase: streptodornase or purified protein derivative) or Th2 (Dermatophagoides pteronyssinus, bee or wasp venom: allergens in sensitive subjects) responses. Cytokine production was measured by sensitive bioassays or enzyme-linked immunosorbent assays. Of the 30 subjects studied, 10 were normal and 20 individuals were allergic to either D. pteronyssinus (n = 10) or bee venom (n = 10) (examined before specific allergen immunotherapy). We examined the temporal profiles of a panel of cytokines produced in prmary culture. In PHA-driven cultures, cytokines were found to be sequentially produced in the order interleukin (IL)-2, IL-4, IL-5, IL-3, interferon (IFN)-γ, IL-10, IL-6, IL-12 and tumor necrosis factor (TNF)-α. The response to allergen in allergic patients was predominantly Th2 in nature, with the production of IL-4, IL-5, IL-6 and IL-10, but little or no IFN-γ. IL-2, IL-3, TNF-α and IL-12 were also produced in low amounts. The response of both atopic and normal subjects to recall bacterial antigens was predominantly Th1, with high levels of IFN-γ, IL-2 and TNF-α. The relevance of the order, amount and speed of production, characteristic kinetics (production, consumption, homeostatic regulation) and the cell source of the cytokines are discussed. 相似文献
72.
The aim of the study was to examine to what extent prior high- or low-intensity cycling, yielding the same amount of external
work, influenced the oxygen uptake (V˙O2) slow component of subsequent high-intensity cycling. The 12 subjects cycled in two protocols consisting of an initial 3 min
period of unloaded cycling followed by two periods of constant-load exercise separated by 3 min of rest and 3 min of unloaded
cycling. In protocol 1 both periods of exercise consisted of 6 min cycling at a work rate corresponding to 90% peak oxygen
uptake (V˙O2peak). Protocol 2 differed from protocol 1 in that the first period of exercise consisted of a mean of 12.1 (SD 0.8) min cycling
at a work rate corresponding to 50% V˙O2peak. The difference between the 3rd min V˙O2 and the end V˙O2 (ΔV˙O2(6−3)) was used as an index of the V˙O2 slow component. Prior high-intensity exercise significantly reduced ΔV˙O2(6−3). The ΔV˙O2(6−3) was also reduced by prior low-intensity exercise despite an unchanged plasma lactate concentration at the start of the second
period of exercise. The reduction was more pronounced after prior high- than after prior low-intensity exercise (59% and 28%,
respectively). The results of this study show that prior exercise of high as well as low intensity reduces the V˙O2 slow component and indicate that a metabolic acidosis is not a necessary condition to elicit a reduction in ΔV˙O2(6−3).
Accepted: 8 July 2000 相似文献
73.
Bai Stephen A. Walle U. Kristina Walle Thomas 《Journal of pharmacokinetics and pharmacodynamics》1985,13(3):229-241
The intravenous and oral dose kinetics of propranolol were studied in the dog both in a fasted state and immediately after a meal consisting of 100 g of cooked beef liver. Fifty Ci of3H-propranolol was administered intravenously simultaneously with a 40-mg oral dose of unlabeled propranolol. Plasma3H-propranolol was measured by specific extraction and liquid scintillation spectrometry, and unlabeled plasma propranolol was determined by gas chromatography-mass spectrometry. Feeding significantly reduced (25%) the elimination half-life and increased (52%) the systemic clearance of intravenous propranolol. The increase in the systemic clearance of propranolol after feeding was mostly due to an increase (60%) in apparent hepatic blood flow, which appeared to remain elevated for 5–7 hr. The meal had no influence on the apparent volume of distribution or plasma binding. Feeding did not affect the area under the concentration-time curve of oral propranolol, but significantly delayed the rate of oral propranolol absorption, shifting the time to reach peak plasma levels from 60 to 158 min. The results of this study suggest that feeding alters the disposition of propranolol in the dog by producing a sustained increase in hepatic blood flow.This work was supported by National Institute of Health grants GM 07534, GM 20387, and HL 29566. 相似文献
74.
Dr. Zsolt Szabó Henning Vosberg Charles A. Sondhaus Ludwig E. Feinendegen 《European journal of nuclear medicine and molecular imaging》1985,11(6-7):265-274
Examination of the input-output events in functioning organs by the use of the impulse-response function (IRF) for a radioactive tracer is gaining more and more ground in nuclear medicine. This study summarizes the development of deconvolution analysis, laying special stress on the model-free approach. System linearity and time invariance are discussed, and means of eliminating noise in IRFs originating from the input and organ-time-activity curves are outlined. Typical IRFs are illustrated by flow diagrams, time-domain curves, and their representation by Laplace transforms. The cases of nondiffusible and diffusible tracers as well as parenchymally extracted and transported substances are discussed. Methods for the derivation of models and for the calculation of physiologically important parameters from theIRFs are suggested.At present, a guest scientist at the Institute for Medicine, Nuclear Research Center Jülich, Jülich, Federal Republic of Germany 相似文献
75.
Michael F. Powell 《Pharmaceutical research》1987,4(1):42-45
The degradation of lidocaine in aqueous solution obeys the expression k
obs = (k
H+[H +] + k
o ) [H+]/([H + ] + K
a + ko
K
a([H + ] + K
a) where k
H+ is the rate constant for hydronium ion catalysis, and k
o and ko are the rate constants for the spontaneous (or water-catalyzed) reactions of protonated and free-base lidocaine. At 80°C, the rate constants for these processes are 1.31 × 10–7
M
–l sec–1, 1.37 × 10–9 sec–1, and 7.02 × 10–9sec–1; the corresponding activation energies are 30.5, 33.8, and 26.3 kcal mol–1, respectively. It was found that the room temperature pH of maximum stability is 3–6 and that lidocaine is more reactive in the presence of metal ions such as Fe2+ and Cu2+. The dissociation constant, K
a, for lidocaine at 25–80°C was also measured at 0.1 M ionic strength and a plot of pK
a versus 1/T gave a slope of (1.88 ± 0.05) × 103 K–1 and intercept 1.56 ± 0.16. 相似文献
76.
以缓和加氢裂化数据为基础,对于两种典型的加氢裂化动力学模型--Stangeland模型和改进MHC模型,使用Shor最优化法进行了参数的拟合,比较了这两种动力学模型的结果、算法、复杂度以及预测能力。结果表明,改进MHC模型是一种更为合理的动力学模型,该模型也可用于实际加氢过程。 相似文献
77.
78.
对低温,低压,高活性的A301氨合成催化剂的本征动力学进行了研究,实验采用等温积分反应器,在320-480度,6.0MPa-10.0MPa,5000h^-1--30000h^-1的条件下测定了反应器出口氨浓度,建立了Temkin形式的动力学方程,获得了反应的活化能及指前因子。 相似文献
79.
Materials are distributed throughout the body of mammals by fractal networks of branching tubes. Based on the scaling laws of the fractal structure, the vascular tree is reduced to an equivalent one-dimensional, tube model. A dispersion–convection partial differential equation with constant coefficients describes the heterogeneous concentration profile of an intravascular tracer in the vascular tree. A simple model for the mammalian circulatory system is built in entirely physiological terms consisting of a ring shaped, one-dimensional tube which corresponds to the arterial, venular, and pulmonary trees, successively. The model incorporates the blood flow heterogeneity of the mammalian circulatory system. Model predictions are fitted to published concentration-time data of indocyanine green injected in humans and dogs. Close agreement was found with parameter values within the expected physiological range. © 2003 Biomedical Engineering Society.
PAC2003: 8710+e, 8719Hh, 8719Uv 相似文献
80.
用双剂量实验数据分析药物的米氏消除参数的识别问题 总被引:1,自引:0,他引:1
本文分析了给药剂量对按一级过程吸收,米氏过程消除药物的血药浓度的峰值与达峰时间的影响。并据此讨论了利用较少的双剂量实验数据改善识别米氏参数的方法。 相似文献