首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   2723篇
  免费   160篇
  国内免费   21篇
耳鼻咽喉   9篇
儿科学   9篇
基础医学   212篇
口腔科学   1471篇
临床医学   87篇
内科学   47篇
皮肤病学   22篇
神经病学   291篇
特种医学   61篇
外科学   161篇
综合类   298篇
预防医学   78篇
眼科学   2篇
药学   114篇
中国医学   31篇
肿瘤学   11篇
  2024年   19篇
  2023年   72篇
  2022年   82篇
  2021年   112篇
  2020年   86篇
  2019年   87篇
  2018年   120篇
  2017年   106篇
  2016年   118篇
  2015年   121篇
  2014年   181篇
  2013年   212篇
  2012年   142篇
  2011年   155篇
  2010年   151篇
  2009年   129篇
  2008年   111篇
  2007年   125篇
  2006年   124篇
  2005年   103篇
  2004年   80篇
  2003年   89篇
  2002年   64篇
  2001年   57篇
  2000年   42篇
  1999年   31篇
  1998年   24篇
  1997年   17篇
  1996年   12篇
  1995年   8篇
  1994年   13篇
  1993年   9篇
  1992年   5篇
  1991年   4篇
  1990年   5篇
  1989年   11篇
  1988年   11篇
  1987年   5篇
  1986年   8篇
  1985年   5篇
  1983年   3篇
  1982年   5篇
  1981年   5篇
  1980年   11篇
  1979年   4篇
  1978年   3篇
  1976年   2篇
  1973年   2篇
  1972年   4篇
  1968年   2篇
排序方式: 共有2904条查询结果,搜索用时 62 毫秒
81.
Objective:To evaluate the effects of different bleaching methods on the shear bond strength (SBS) of orthodontic brackets.Materials and Methods:Forty-five freshly extracted premolars were randomly divided into three groups (n  =  15 per group). In group I, bleaching was performed with the office bleaching method. In group II, bleaching was performed with the home bleaching method. Group III served as the control. Orthodontic brackets were bonded with a light cure composite resin and cured with an LED light. After bonding, the SBS of the brackets were tested with a Universal testing machine.Results:Analysis of variance indicated a significant difference between groups (P < .001). The highest values for SBS were measured in group III (20.99 ± 2.32 MPa). The SBS was significantly lower in groups I and II than in group III (P < .001). The lowest values for SBS were measured in group II (6.42 ± 0.81 MPa). SBS was significantly higher in group I than in group II (P < .001).Conclusions:Both of the bleaching methods significantly affected the SBS of orthodontic brackets on human enamel. Bleaching with the home bleaching method affected SBS more adversely than did bleaching with the office bleaching method.  相似文献   
82.
Background: The prevalence and severity of tooth wear and dental erosion is rising in children and there is no consensus about an index to be employed. Aim: To assess the reliability of an epidemiological scoring system dental wear index (DWI) to measure tooth wear and dental erosive wear. Design: An epidemiological cross‐sectional survey was conducted to evaluate and compare tooth wear and dental erosion using the dental wear index and erosion wear index (EWI). The study was conducted with randomised samples of 2,371 children aged between 4 years and 12 years selected from the State of São Paulo, Brazil. Records were used for calculating tooth wear and dental erosion; the incisal edge and canine cusp were excluded. Results: As the schoolchildren's ages increased the severity of primary tooth wear increased in canines (= 0.0001, OR = 0.34) and molars (P = 0.0001, OR = 2.47) and erosion wear increased in incisal/occlusal (P = 0.0001, OR = 5.18) and molars (P = 0.0001, OR = 2.47). There was an increased prevalence of wear in the permanent teeth of older schoolchildren, particularly on the incisal/occlusal surfaces (P = 0.0001, OR = 7.03). Conclusion: The prevalence of tooth wear and dental erosion increased as age increased in children. The epidemiological scoring system Dental Wear Index is able to measure both tooth wear and dental erosive wear. This index should be used to monitor the progression of non‐carious lesions and to evaluate the levels of disease in the population.  相似文献   
83.

Objectives

The aim of this study was to find out whether Toothguide Trainer, TT, and Toothguide Training Box, TTB, show any training effects, independent of the shade guide chosen.

Methods

Students from four dental schools (N = 78) were included in this study. The participants were randomized into a study, 42 students (age range: 19–27 years; 69% female, 31% male) and a control group of 36 students (age range: 19–30 years; 57% female, 43% male). The study group started with a double blind introduction test, followed by the TT and TTB training, finishing with the final test. The control group only passed the introduction and – after a break – the final test. Eight randomly chosen samples, seven of the Vita classical and one of the 3D-Master colour scale, were marked by barcodes. Colour matching was arranged by the Vita classical scale.

Results

The results of the pre- and final tests of both groups were combined. For every sample, the value ΔE was determined. The summation of all eight samples from the introduction and final tests offered a summarized ΔE value. The differences between introduction and final tests revealed the individual learning success. 47.6% of the study group showed statistically significant better results than the control group, 33% (p = 0.031).

Conclusion

TT and TTB show a positive effect of training on tooth shade matching independent of the colour scale used.

Clinical significance

Visual shade taking is the most frequent clinical method for shade determination. To increase better results in visual colour matching, TT and TTB training is used. This is the first study examining the training effect of TT and TTB using Vita classical scale.  相似文献   
84.

Objective

The aim of this study is to demonstrate whether articaine hydrochloride administered alone as a single buccal infiltration in maxillary tooth removal, can provide favourable palatal anesthesia as compared to buccal and palatal injection of lidocaine.

Study Design

The study population consisted of 30 patients who were undergoing orthodontic treatment, and who required bilateral extraction of maxillary permanent premolars as per their orthodontic treatment plan. On the experimental side, 4 % articaine/HCl was injected into the buccal vestibule of the tooth to be extracted. On the control side, 2 % lignocaine HCl was injected both into the buccal and the palatal side of the tooth to be extracted. Following tooth extraction all patients completed a 100-mm visual analogue scale (VAS) and faces pain scale (FPS) to rate the pain on extraction.

Results

According to the VAS and FPS scores, the pain on extraction between buccal infiltration of articaine and the routine buccal and palatal infiltration of lignocaine was statistically insignificant.

Conclusions

The routine use of a palatal injection for the removal of permanent maxillary premolar teeth may not be required when articaine/HCl is used as the local anesthetic.  相似文献   
85.
目的:研究不同浓度肿瘤坏死因子-α(TNF-α)对体外培养人牙囊细胞凋亡的影响。方法:第五代HDFCs分别与浓度为0(对照组)、50、100、200 ng/mL的TNF-α共孵育24 h,流式细胞仪AnnexinⅤ-FITC/PI双染技术检测牙囊细胞凋亡细胞比率。结果:HDFCs的凋亡率随TNF-α浓度升高而上升,由对照组的2.3%增加到7.1%。结论:TNF-可诱导HDFCs的凋亡,这种作用可能在牙齿发育、萌出过程中起重要作用。  相似文献   
86.
PurposeThe purpose of this study was to examine the electric current induced in teeth and tooth-bonded brackets by electromagnetic fields from electric toothbrushes and the curing lights used for photo-activating light-cured resins.Materials and methodsCuring lights-generated low-frequency magnetic fields (1–2000 Hz) were measured with a spectrum analyzer. Temperature changes induced in the enamel and pulpal dentin surface of extracted upper premolar teeth (with or without a stainless steel or zirconia bracket) by electric toothbrushes and curing lights were estimated using an infrared thermometer. Electric current induced in these extracted teeth by electric appliances was estimated using a digital multimeter.ResultsCuring lights generated low-frequency magnetic fields. Irradiation of the tooth surface by curing lights elevated the temperature of the enamel and pulpal dentin surfaces, but there were no differences between curing lights. About electric current induced in extracted teeth (with or without a bracket) by electric toothbrushes and curing lights, the highest current was induced in teeth to which a zirconia bracket was bonded, whereas the lowest current was in unmodified teeth. Intermediate currents were generated in teeth bonded to stainless steel brackets.ConclusionThe low-frequency magnetic fields induced by electric toothbrushes and light curing units induce electric current in tooth tissue, irrespective of whether these teeth are bonded to stainless steel or zirconia brackets.  相似文献   
87.
ObjectiveA mixture of ciprofloxacin, metronidazole, and minocycline (3Mix) has been reported to be effective against oral bacteria from carious and endodontic lesions in vitro and in vivo. The objective of this study was to establish an animal model using mice for the application of 3Mix following intentionally delayed tooth replantation and to investigate the effects of 3Mix on the healing process of dental pulp and periodontal tissues.MethodsUpper first molars of ICR mice were extracted, immersed in 3Mix solution at different concentrations for 5–60 min with or without the use of a transfer solution (phosphate buffer solution (PBS)), in addition to transfer solution alone, and subsequently repositioned in the sockets. Immunohistochemistry for nestin and Ki-67, histochemistry for TRAP, and TUNEL assay were performed to assess pulpal healing during days 7–21.ResultsIncreased apoptosis was observed in the PBS group at week 1, followed by cell proliferation at week 2, and tertiary dentin and/or bone-like tissue formation at week 3. In contrast, nestin-positive, newly differentiated, odontoblast-like cells began to align along the pulp–dentin border following the appearance of Ki-67- and TUNEL-positive cells during weeks 1–2 in the 3Mix groups, suggesting that pulpal healing was accelerated. Severe root ankylosis was observed exclusively in the 3Mix groups. Rinsing with PBS before replantation partially rescued the viability of the periodontal ligament, but pulpal healing was delayed.ConclusionsThe application of 3Mix promotes pulpal regeneration of intentionally delayed replanted teeth; however, its use may induce severe damage to periodontal tissues.  相似文献   
88.
Reports     
Abstract

In the past, vertical intrusive movement of teeth has been considered difficult and most routine clinical vertical movement of teeth has been confined to extrusion. It has been suggested that attempts at intrusion may result in an increased incidence of root resorption and also in occasional devitalization.

The displacement and resulting stress fields associated with such treatment can be successfully studied using the finite element method. In the case being considered initial movements are known to be small; therefore, the assumption in the study that the material behaves linear-elastically is considered to be reasonable.

This study of vertical tooth movement demonstrated that the maximum cervical margin stress in the periodontal ligament was 0·0046 N/mm2, whilst the highest apical stress was 0·00205 N/mm2 when intrusive and extrusive forces of 1 Newton were applied to the buccal surface of the crown of a tooth model. These stresses were evaluated in the light of previous studies and found to be within the suggested clinical optimum level. However, the periodontal stress distribution following orthodontic loading within this three-dimensional finite element model was found to be highly complex.  相似文献   
89.
目的观察D.T Light post纤维桩修复喇叭口型根管残根残冠的临床疗效。方法 26例患者需要修复的35颗患牙,经完善的根管治疗后,采用D.T Light post纤维桩,DUO-LINKTM双固化树脂粘接剂,Light-Core光固化树脂核材料恢复桩核,钴铬合金烤瓷冠修复。分别对患者于1、6、12、18、24个月随访观察,通过临床和X线片检查评估修复体的临床疗效。结果 35颗患牙均无桩冠脱落或松动,成功率为100%。结论 D.T Light post纤维桩系统材料修复喇叭口型根管的残根残冠效果良好,但长期效果有待进一步观察。  相似文献   
90.
Objective:To evaluate the mean dimensions and morphologic characteristics of mandibular premolars that had mesiodistally elongated and faciolingually squeezed tooth shape deviations (MnP-TSD) and determine the population prevalence of this anomaly.Materials and Methods:Clinical photographs and study models were made for all new patients with MnP-TSD teeth who were seen over 20 years. The mesiodistal (MD) and faciolingual (FL) dimensions of the anomalous premolars were measured. MD/FL indices and MD × FL mm2 occlusal crown areas were calculated and means and standard deviations were derived. Male and female means from the mandibular first and second anomalous premolars (MnP1/MnP2-TSD) were statistically compared against gender-specific means derived from published normative data using Student''s t-tests and chi-square tests.Results:Fifty-six individuals (33 male and 23 female) with MnP-TSD were identified, giving a male to female ratio of 1.4∶1, while the prevalence rate in the indigenous British population was estimated to be 0.6%. The MD widths of the MnP1-TSD and MnP2-TSD teeth were approximately 1 mm wider than normal, while the FL diameters were about 0.5 mm and 1.5 mm narrower respectively, for the first and second premolar teeth. The MD/FL indices, instead of being under 90 as usual were above 100, while the mean MD/FL mm2 crown surface areas were normal.Conclusions:This study supplies odontometric dimensional and morphologic data on MnP-TSD teeth that provide a reference source for future comparisons.  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号