攻癌镇痛散联合氯化锶治疗骨转移性癌痛临床观察

目的 探讨攻癌镇痛散联合氯化锶(89SrCl2)治疗骨转移性癌痛临床疗效及安全性.方法 选择2012年1月-2016年10月收治的骨转移性癌痛148例,按治疗方法分为对照组和观察组,每组74例.对照组在常规治疗基础上给予89SrCl2治疗,观察组在对照组基础上予攻癌镇痛散治疗.观察2组疼痛程度、镇痛起效时间、疗效持续时间、生活质量及临床疗效,并记录不良反应发生情况.结果 2组治疗后疼痛程度和生活质量均较治疗前改善,且观察组改善程度优于对照组(P＜0.05).观察组镇痛起效时间短于对照组,疗效持续时间长于对照组(P＜0.05).观察组临床总有效率高于对照组(P＜0.05).2组不良反应发生率比较差异无统计学意义(P＞0.05).结论 攻癌镇痛散联合89SrCl2治疗骨转移性癌痛临床效果较好,且安全性较高.     

Impact of silanization of different bioactive glasses in simplified adhesives on degree of conversion,dentin bonding and collagen remineralization

ObjectiveTo analyze simplified adhesive containing pure or silanized bioglass 45S5 (with calcium) or Sr-45S5 (strontium-substituted) fillers applied on dentin and to evaluate the microtensile bond strength (µTBS), interface nanoleakage, degree of conversion of adhesive, collagen degradation and remineralization.MethodsAmbar Universal adhesive (FGM) was doped with 10 wt% bioactive glasses to form following groups: Control (no bioglass), 45S5 (conventional bioglass 45S5), Sr-45S5 (Sr-substituted bioglass 45S5), Sil-45S5 (silanized bioglass 45S5) and Sil-Sr-45S5 (silanized bioglass Sr-45S5). Adhesives were applied after dentin acid-etching using phosphoric acid at extracted human molars. Resin-dentin sticks were obtained and tested for µTBS, nanoleakage at 24 h or 6 months. Degree of conversion was measured using micro-Raman spectroscopy. Dentin remineralization was assessed by FTIR after 6-month storage in PBS. Hydroxyproline (HYP) release was surveyed by UV-Vis spectroscopy. Statistical analysis was performed using ANOVA and Tukey’s test (p < 0.05).ResultsRegarding µTBS, Sr-45S5 and 45S5 presented higher and stable results (p > 0.05). Control (p = 0.018) and Sil-Sr-45S5 (p < 0.001) showed µTBS reduction after 6-month aging. Sil-Sr-45S5 showed higher HYP release than that obtained in the 45S5 group. Sil-45S5 showed mineral deposition and increase in µTBS (p = 0.028) after 6-months. All experimental adhesives exhibited higher degree of conversion compared to Control group, except for 45S5. All adhesives created gap-free interfaces, with very low silver impregnation, except for Sil-Sr-45S5.SignificanceThe incorporation of silanized 45S5 bioglass into the universal adhesive was advantageous in terms of dentin remineralization, bonding performance and adhesive polymerization. Conversely, Sil-Sr-45S5 compromised the µTBS, interface nanoleakage and had a negative impact on HYP outcomes.