Primary squamous metaplasia of the breast

A case of primary or idiopathic squamous metapiasia of the breast occurring in a 45-year-old woman is presented. Immunohistochemical studies suggested that the metapiasia had arisen in ductular eplthellum. No evidence of neopiasia was identiffied.     

喉鳞癌组织中P53和bc1—2蛋白的表达

用免疫组化ＬＳＡＢ法对５３例喉鳞状细胞癌（ＬＳＣＣ）癌组织的Ｐ５３和ｂｃ１－２蛋白表达进行了检测。结果表明５３例ＬＣＳＳ中２５例（４７．１７％）突变型Ｐ５３蛋白表达为阳性，同时一些癌旁不典型增生上皮中也有Ｐ５３表达，说明突变型Ｐ５３表达可能是ＬＳＣＣ发展的早期事件。此外，在所有检测病例中ｂｃ１－２蛋白表达率为６９．８１％（３７／５３），ｂｃ１－２蛋白表达和Ｐ５３蛋白表达间未见到相关关系     

Neck mass with marked squamous metaplasia: a diagnostic pitfall in aspiration cytology

Fine-needle aspiration cytology (FNAC) is a highly accurate tool for the diagnosis of pleomorphic adenomas; however, this common salivary gland neoplasm can be diagnostically challenging, causing pitfalls in cytodiagnosis. A 50-year-old woman suffered from a painless, slowly-growing mass in the right posterior upper neck for 5 months. FNAC from this mass revealed many discohesive parakeratotic cells and keratin flakes, and a few stromal elements. Under the impression of metastatic well-differentiated squamous cell carcinoma, the tumor mass was totally excised. Histology confirmed a pleomorphic adenoma with marked squamous metaplasia and frequent keratin pearl formations without the evidence of malignancy. Pleomorphic adenoma occasionally reveals focal squamous metaplastic changes, when extensive, it may be misdiagnosed as metastatic well-differentiated squamous cell carcinoma in FNAC, particularly in the neck region.     

胃粘膜肠上皮化生的分型及其与胃癌发生的关系

对576例胃粘膜活检肠化标本及85例正常成人及胎儿胃肠粘膜标本进行粘液组织化学染色,将肠化分为3型:Ⅰ型为完全型;Ⅱ和Ⅲ型为不完全型。Ⅱ和Ⅲ型的区别在于后者柱状粘液细胞含有硫酸粘液,而前者则无硫酸粘液。结果表明,Ⅲ型肠化在胃癌及不典型增生组的检出率显著高于其它良性病变组(P<0.05～0.01)。硫酸粘液不仅存在Ⅲ型肠化的柱状细胞,也存在各型肠化的杯状细胞,仅杯状细胞含有硫酸粘液的肠化在胃癌及其它良性胃病粘膜的检出率无显著差异(P>0.05)。以上结果提示,Ⅲ型肠化与胃癌的发生有密切关系,对Ⅲ型肠化定期随访可能有助于胃癌的早期发现。     

α-Interferon in myelofibrosis: a case report

Summary. A patient with advanced myeloid metaplasia was treated with α-interferon (29 months) with a remarkable response. He had anaemia, thrombocytopenia and hepatosplenomegaly with infarction. The initial bone marrow showed replacement with fibrosis with no evident haemopoietic cells. Post-therapy, the patient became asymptomatic, transfusion independent and had normal blood counts. The repeat bone marrow was 30% cellular with 1 + reticulin and no fibrosis. Treatment was well tolerated without appreciable side-effects. These results indicate that prolonged therapy with α-interferon can improve haemopoiesis and reverse marrow fibrosis.     

颌面部鳞癌细胞生物学特性及p21蛋白表达的定量分析

本文应用双抗体标记和流式细胞分析技术，对５５例颌面部鳞状上皮源性良恶性肿瘤及正常组织进行ＤＮＡ指数、增殖指数、Ｓ期细胞比例及ｐ２１蛋白的表达进行了定量分析。结果：正常皮肤和乳头状瘤均为二倍体，鳞癌异倍体率为６０％，并随病理分级增高而增高；增殖指数和Ｓ期细胞所占的百分比在这三种组织中均有显著性差异；正常组织ｐ２１蛋白的表达为阴性；乳头状瘤ｐ２１蛋白阳性表达率为３０％；鳞癌ｐ２１阳性表达率为７０％；鳞癌ｐ２１蛋白的阳性表达率和表达强度均显著高于其它两种组织。结论认为ｐ２１蛋白在良性肿瘤中也有部分阳性表达。但表达率显著低于恶性肿瘤，ｐ２１蛋白的检测在用于对易恶变疾病的监测方面的作用要大于用在对恶性肿瘤恶性度的判定方面     

Squamous cell carcinoma of the esophagus in Fanconi's anemia

The fifth reported case of esophageal carcinoma complicating Fanconi's pancytopenia is described and discussed. This is a rare complication of Fanconi's anemia, which is uncommonly associated with squamous cell malignancies and more commonly with leukemia.     

Squamous cell carcinoma in patients with necrobiosis lipoidica

Summary Two cases of squamous cell carcinoma each arising in an area of necrobiosis lipoidica are presented. Malignant change should be suspected when proliferative keratosis or chronic ulceration develops within lesions of necrobiosis lipoidica. Sampling biopsy may be misleading.     

喉鳞状细胞癌中VEGF表达的临床意义

目的　为探讨血管内皮细胞生长因子 (VEGF)在喉鳞状细胞癌中表达的临床意义。　方法　采用免疫组化SP法检测 60例喉癌和 10例正常粘膜VEGF的表达及VEGF和微血管密度 (MVD)的关系。结果　VEGF蛋白表达 :①正常喉粘膜组与喉癌组阳性表达率分别为 2 0 .0 % ( 2 / 10 )和 71.7% ( 4 3/ 60 ) (P<0 .0 1)。②喉癌Ⅰ级组与Ⅱ、Ⅲ级组阳性表达率分别为 57.1% ( 12 / 2 1)和 92 .3% ( 36/ 39) (P <0 .0 1)。③喉癌生存组与死亡组阳性表达率分别为 30 .0 % ( 6/ 2 0 ) ,80 .0 % ( 8/ 10 ) (P <0 .0 5)。MVD( χ±s表示 ) :①喉癌Ⅰ级组与Ⅱ、Ⅲ级组分别为 2 1.33± 14.16,4 3.67± 2 5.2 3(P <0 .0 1)。②喉癌生存组与死亡组分别为2 1 77± 11 74 ,4 0 71± 2 6 4 1(P <0 .0 5)。③喉癌VEGF蛋白表达阳性组与阴性组分别为 37 4 5± 2 4 4 5,18 88± 11 2 7(P <0 .0 1)。结论　VEGF蛋白表达和MVD和喉癌分级、预后相关 ,VEGF蛋白是喉癌重要的血管生成因子。针对VEGF蛋白的抗血管生成治疗可望成为喉癌一种新的辅助治疗方法。     

喉癌EGFR和PCNA表达及DNA含量的研究

研究喉鳞癌中表皮生长因子受体、增殖细胞核抗原的表达和ＤＮＡ含量,分析各指标间的相关性及与喉癌临床生物学行为和预后的关系。方法：用免疫组化ＳＰ法和图像分析仪检测正常喉粘膜、喉鳞癌的ＥＧＦＲ、ＰＣＮＡ和ＤＮＡ指数,结合临床资料进行分析。结果：喉鳞癌的ＥＧＦＲ的阳性表达率为５４．８％,与正常喉组织的差异有统计学意义,但ＥＧＦＲ的阳性表达与喉癌的病理分级和５年生丰率无显著相关,而ＰＣＮＡ阳性表达和ＤＩ则随