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31.
J. S. Schneider J. R. Morse T. I. Lidsky PhD 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1982,46(2):311-314
Summary The somatosensory properties of globus pallidus (GP) neurons were assessed in awake restrained cats. Forty-two percent of GP units responded to stimulation of the face. Receptive fields were typically bilateral (49%) or contralateral and 75% included perioral tissue.Responsive units showed little ability to encode force. In contrast, cells were sensitive to changes in stimulus location within the receptive zone. The majority of cells so tested showed enhanced responding to stimuli applied within the perioral zone.Many (42%) of the cells which responded to brushing of the guard hairs or vibrissa were directionally sensitive. Of those, 89% showed enhanced responding to stimuli which moved toward the front of the mouth.These data were discussed in relation to a role of the GP in feedback regulated head positioning movements.Supported by N.I.N.C.D.S. grant NS 16054 相似文献
32.
G. F. Koshland J. L. Smith 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1989,77(2):361-373
Summary To determine the effects of atypical motion-related feedback on motor patterns of the paw shake, EMG patterns of selected flexor and extensor muscles were recorded under four conditions of joint immobilization (hip and ankle alone, hip-knee, hip-knee-ankle) and compared to responses evoked in the freely-moving hindlimb of the chronic-spinal cat. With only the ankle joint casted, paw shaking was easily evoked by applying tape to the paw, and cyclic characteristics were not altered. However, under the three conditions with hip-joint immobilization (hip alone, hip-knee, hip-knee-ankle), responses were difficult to obtain, and if elicited, the number of cycles within a response decreased and cycle periods were prolonged. The temporal organization of consecutive cycles, however, was not altered by immobilization of any joint(s). Ankle (LG) and hip (GM) extensor activity was relatively unaffected by conditions of joint immobilization. In contrast, hip flexor (IP) and knee extensor (VL) bursts were often absent under all three conditions of hip-joint immoblization, and if present, VL burst durations decreased under the casted hip-knee-ankle condition, while the onset of IP activity occurred early in the cycle with prolonged bursts under casted ankle and casted hip-knee-ankle conditions. The coactivity of the knee extensor (VL) and ankle flexor (TA) was disrupted by conditions of hip-joint immobilization: VL onset was dissociated from TA onset and coincident with LG onset. These results suggest that motion-related feedback from the hip joint is particularly important in the initiation, cycle frequency, and the number of cycles of paw-shake responses. The presence of atypical motion-dependent feedback from the hip joint altered activity of knee and ankle anterior muscles, while motion-dependent feedback from the ankle joint changed activity of the anterior hip muscle. Moreover, the results suggest a differential control of posterior and anterior muscles of the hindlimb, consistent with paw-shake limb dynamics. 相似文献
33.
Mechanisms of peptide YY release induced by an intraduodenal meal in rats: neural regulation by proximal gut 总被引:5,自引:0,他引:5
Fu-Cheng Xiaomei Anini Younes Chariot Jacques Castex Nathalie Galmiche Jean-Paul Rozé C. 《Pflügers Archiv : European journal of physiology》1997,433(5):571-579
Peptide YY (PYY) release in anaesthetized rats was studied during the 2 h following the intraduodenal administration of a
semi-liquid meal of 21 kJ. Surgical and pharmacological manipulations were performed in order to analyse the mechanisms of
PYY release. Postprandial PYY release was suppressed or strongly decreased by caecocolonectomy, truncal vagotomy, tetrodotoxin,
hexamethonium, sensory denervation by perivagal capsaicin, and by the NO-synthase inhibitor L-N-arginine methyl ester, while atropine, adrenergic blockers, antagonists of type-A or type-B cholecystokinin (CCK) receptors
or bombesin receptors had no effect. Comparing the digestive transit of the semi-liquid meal with the amount of PYY contained
in the small bowel wall showed that nutrients had not reached the area rich in cells containing PYY by 30 min, the time at
which there was a large PYY release in plasma. By 120 min, the meal front had travelled 72% of the small intestine length,
just beginning to reach the PYY-rich part of the ileum. We conclude that the main postprandial PYY release studied in this
model comes from ileal and colonic L-cells indirectly stimulated through a neural mechanism originating in the proximal gut
and involving sensory vagal fibres, nicotinic synapses and NO release, while CCK and bombesin do not seem to be physiologically
involved.
Received: 17 July 1996 / Received after revision: 11 October 1996 / Accepted: 18 October 1996 相似文献
34.
Lamellar cells of sensory receptors and perineural cells of nerve endings of pig skin contain cytokeratins 总被引:1,自引:0,他引:1
Jean-Paul Ortonne Patrick Verrando Gérard Pautrat Michel Darmon 《Virchows Archiv : an international journal of pathology》1987,410(6):547-552
Summary The lamellar cells of the sensory corpuscles of the pig dermis must be considered to be epithelial cells as they contain cytokeratins. The cytokeratins detected are similar to those found in simple epithelia. Moreover, lamellar cells are embedded in an extracellular matrix reminiscent of the basement membrane of epithelium since it contains laminin and collagen IV. The perineural cells surrounding the nerves of pig dermis present the same features.These results suggest that lamellar cells and perineural cells have the same origin. The nature of the lamellar and perineural cells of the rabbit or human dermis is not as clear since cytokeratins were not detected in those cells. These results, together with recent observations on Merkel cells, may indicate that epithelio-neuronal junctions are a general feature of cutaneous sensory receptors. 相似文献
35.
Kengo Funakoshi Masato NakanoYoshitoshi Atobe Tetsuo KadotaRichard C. Goris 《Neuroscience letters》2006
The visceral reflexes of the pelvic organs are mediated by connections between primary afferents innervating the pelvic organs and parasympathetic preganglionic neurons in the intermediolateral column of the sacral spinal cord. The present immunohistochemical study revealed many varicosities expressing transient receptor potential vanilloid 1 (TRPV1) that were closely apposed to the preganglionic neuronal perikarya at embryonic day 16 in mice. Many, but not all, varicosities expressing TRPV1 in the intermediolateral column were also immunopositive for calcitonin gene-related peptide. In contrast, no nerve fibers expressing TRPV1 projected to the sympathetic preganglionic cell column in the lumbar spinal cord in prenatal stages. The results of the present study raised the possibility that the primary afferents transmit signals elicited by the activation of TRPV1 receptors to the sacral parasympathetic preganglionic neurons. Thus, the functional circuit for pelvic spinal reflexes, such as micturition induced by urine influx, might develop in the prenatal stages in mice. 相似文献
36.
Norihiro Suzuki Jan Erik Hardebo Jan K hrstr m Christer Owman 《Neuroscience letters》1989,100(1-3):123-129
Galanin (GAL)-positive nerve fibers in rat cerebral vessels were demonstrated by immunohistochemistry, and their origin in the trigeminal ganglia and pathway in the nasociliary nerve to the vessels was shown by retrograde tracer technique and nerve transection. Some fibers in the vertebrobasilar system appear to originate in extracranial sources. With the antiserum used only few GAL fibers could be seen in the vessels, mostly in the vertebrobasilar system. In neonatally sympathectomized animals a rich network could be visualized in most pial arteries - still particularly in the vertebrobasilar system - probably as a result of a diminished competition for nerve growth factor. No vasomotor effect of GAL could be detected in isolated segments of pial arteries, neither in normal nor in sympathectomized animals, which rules out a direct postsynaptic effect on vascular tone. GAL did not display prejunctional modulatory action on the adrenergic nerves present in the vascular preparations. A sensory function of GAL is discussed. 相似文献
37.
The relationship between cardiac activity and sensory acuity suggested by Lacey and Lacey was tested by recording heart rates of Ss attempting to detect a threshold-level visual stimulus. Heart rate decelerations during a warning tone preceding the threshold stimulus were found in be greater on hit trials than on miss trials, supporting the suggested relationship. 相似文献
38.
Wieslaw W. Pawlik Piotr Gustaw Eugene D. Jacobson Ryszard Sendur Krzysztof Czarnobilski 《Pflügers Archiv : European journal of physiology》1995,429(3):301-305
It has long been recognized that intestinal blood flow increases at mealtimes. Mesenteric hyperaemia is also evoked by activation of sensory peptidergic nerves. Our studies explored the possible role of endogenous nitric oxide (NO) in the rat intestinal vasodilator response to luminal instillation of an oleic acid plus bile mixture before and after acute intrajejunal instillation of capsaicin and after chronic pretreatment with capsaicin. In anaesthetized rats we measured jejunal blood flow (BF) with an ultrasonic Doppler flowmeter and systemic arterial pressure (AP) with a pressure transducer. Intestinal perfusion with 80 mM oleic acid in bile increased BF by 98±12%. Instillation of 4 mg of capsaicin into the jejunal lumen initially increased BF by 42±9% but was followed by vasoconstriction. Inhibition of NO synthase with 25 mg/kg i.v. N-nitro-L-arginine (L-NNA) decreased BF by 27±5% and increased AP by 37±11%. After treatment with L-NNA and after acute and chronic administration of capsaicin, the bile-oleate-induced maximal increases in BF above control levels were 42±7%, 65±12%, and 58±8%, respectively. The observed inhibitory effect of L-NNA on the intestinal hyperaemic response to the bile-oleate mixture was reversed by pretreatment with L-arginine (100 mg/kg i.V.). In capsaicin pretreated rats the subsequent bile-oleate-induced hyperaemia was reduced in magnitude but the inhibitory effects of L-NNA were proportionately the same as in animals not receiving capsaicin. These findings support the hypothesis that NO is involved with bile-oleate-induced mesenteric hyperaemia. 相似文献
39.
The Effect of Small Variation of the Frequent Auditory Stimulus on the Event-Related Brain Potential to the Infrequent Stimulus 总被引:1,自引:0,他引:1
Istvan Winkler. Petri Paavilainen Kimmo Alho Kalevi Reinikainen Mikko Sams Risto Naatanen 《Psychophysiology》1990,27(2):228-235
We investigated whether the mismatch process between a rare stimulus and the trace of frequent stimulus, which generates the mismatch-negativity component of the event-related potential, can tolerate a small variation in the intensity of the frequent stimulus. Series of short tone pips were presented to 10 subjects while they were reading a book and ignoring the auditory stimuli. The intensity (mean 80dB) of the frequent stimulus (600 Hz) varied within a range that was different in different blocks. The probability of the infrequent stimuli which were, in different blocks, either intensity deviants (600 Hz/70dB) or frequency deviants (650 Hz/80dB) was 10%. Both deviant stimuli elicited mismatch negativity even when the intensity of the frequent stimulus varied, although the amplitude of this component decreased with the increasing variability of the frequent stimulus. These results show that the generator process of mismatch negativity tolerates some variation in the repetitive stimulus, thus indicating that this process is also activated in ecologically more valid conditions. This is crucial to the interpretation of the generator process of mismatch negativity as a biologically vital warning mechanism. 相似文献
40.
Nicole Chabot Valérie CharbonneauMarie-Eve Laramée Robin TremblayDenis Boire Gilles Bronchti 《Neuroscience letters》2008
Anatomical and imaging studies show ample evidence for auditory activation of the visual cortex following early onset of blindness in both humans and animal models. Anatomical studies in animal models of early blindness clearly show intermodal pathways through which auditory information can reach the primary visual cortex. There is clear evidence for intermodal corticocortical pathways linking auditory and visual cortex and also novel connections between the inferior colliculus and the visual thalamus. A recent publication [L.K. Laemle, N.L. Strominger, D.O. Carpenter, Cross-modal innervation of primary visual cortex by auditory fibers in congenitally anophthalmic mice, Neurosci. Lett. 396 (2006) 108–112] suggested the presence of a direct reciprocal connection between the inferior colliculus and the primary visual cortex (V1) in congenitally anophthalmic ZRDCT/An mice. This implies that this mutant mouse would be the only known vertebrate having a direct tectal connection with a primary sensory cortex. The presence of this peculiar pathway was reinvestigated in the ZRDCT/An mouse with highly sensitive neuronal tracers. We found the connections normally described in the ZRDCT/An mouse between: (i) the inferior colliculus and the dorsal lateral geniculate nucleus, (ii) V1 and the superior colliculus, (iii) the lateral posterior nucleus and V1 and between (iv) the inferior colliculus and the medial geniculate nucleus. We also show unambiguously that the auditory subcortical structures do not connect the primary visual cortex in the anophthalmic mouse. In particular, we find no evidence of a direct projection from the auditory mesencephalon to the cortex in this animal model of blindness. 相似文献