全文获取类型
收费全文 | 3450篇 |
免费 | 318篇 |
国内免费 | 30篇 |
专业分类
耳鼻咽喉 | 12篇 |
儿科学 | 36篇 |
妇产科学 | 37篇 |
基础医学 | 293篇 |
口腔科学 | 26篇 |
临床医学 | 522篇 |
内科学 | 117篇 |
皮肤病学 | 10篇 |
神经病学 | 396篇 |
特种医学 | 39篇 |
外科学 | 86篇 |
综合类 | 593篇 |
预防医学 | 652篇 |
眼科学 | 12篇 |
药学 | 446篇 |
中国医学 | 478篇 |
肿瘤学 | 43篇 |
出版年
2024年 | 19篇 |
2023年 | 87篇 |
2022年 | 133篇 |
2021年 | 166篇 |
2020年 | 152篇 |
2019年 | 142篇 |
2018年 | 128篇 |
2017年 | 122篇 |
2016年 | 119篇 |
2015年 | 128篇 |
2014年 | 295篇 |
2013年 | 357篇 |
2012年 | 263篇 |
2011年 | 325篇 |
2010年 | 224篇 |
2009年 | 184篇 |
2008年 | 191篇 |
2007年 | 173篇 |
2006年 | 130篇 |
2005年 | 88篇 |
2004年 | 62篇 |
2003年 | 60篇 |
2002年 | 46篇 |
2001年 | 27篇 |
2000年 | 28篇 |
1999年 | 20篇 |
1998年 | 18篇 |
1997年 | 16篇 |
1996年 | 8篇 |
1995年 | 7篇 |
1994年 | 8篇 |
1993年 | 7篇 |
1992年 | 11篇 |
1991年 | 11篇 |
1990年 | 6篇 |
1989年 | 6篇 |
1988年 | 5篇 |
1987年 | 2篇 |
1986年 | 2篇 |
1984年 | 3篇 |
1983年 | 1篇 |
1982年 | 1篇 |
1981年 | 4篇 |
1979年 | 2篇 |
1976年 | 1篇 |
1975年 | 1篇 |
1973年 | 1篇 |
1972年 | 5篇 |
1971年 | 1篇 |
1966年 | 1篇 |
排序方式: 共有3798条查询结果,搜索用时 15 毫秒
61.
ObjectiveExposure to childhood trauma (CT) is associated with cognitive impairment in schizophrenia, and deficits in social cognition in particular. Here, we sought to test whether IL-6 mediated the association between CT and social cognition both directly, and sequentially via altered default mode network (DMN) connectivity.MethodsThree-hundred-and-eleven participants (104 patients and 207 healthy participants) were included, with MRI data acquired in a subset of n = 147. CT was measured using the childhood trauma questionnaire (CTQ). IL-6 was measured in both plasma and in toll like receptor (TLR) stimulated whole blood. The CANTAB emotion recognition task (ERT) was administered to assess social cognition, and cortical connectivity was assessed based on resting DMN connectivity.ResultsHigher IL-6 levels, measured both in plasma and in toll-like receptor (TLR-2) stimulated blood, were significantly correlated with higher CTQ scores and lower cognitive and social cognitive function. Plasma IL-6 was further observed to partly mediate the association between higher CT scores and lower emotion recognition performance (CTQ total: βindirect −0.0234, 95% CI: −0.0573 to −0.0074; CTQ physical neglect: βindirect = −0.0316, 95% CI: −0.0741 to −0.0049). Finally, sequential mediation was observed between plasma IL-6 levels and DMN connectivity in mediating the effects of higher CTQ on lower social cognitive function (βindirect = −0.0618, 95% CI: −0.1523 to −0.285).ConclusionThis work suggests that previous associations between CT and social cognition may be partly mediated via an increased inflammatory response. IL-6′s association with changes in DMN activity further suggest at least one cortical network via which CT related effects on cognition may be transmitted. 相似文献
62.
Muna Shrestha Helen Shi Mark Strohmeier Ales Medek 《Journal of pharmaceutical sciences》2021,110(4):1592-1600
Physical or chemical interactions between drug product (DP) components can occur during manufacturing and/or upon storage; and may alter DP shelf life and performance. In this work a new Powder X-ray Diffraction (PXRD) peak was observed in DP under accelerated storage conditions. Due to the complex drug product matrix (including API, polymer, fillers, super disintegrant and lubricant), it was challenging to pinpoint the component(s) responsible for the new peak. In addition to PXRD, other orthogonal techniques including Differential Scanning Calorimetry (DSC), thermogravimetric analysis (TGA), dynamic vapor sorption (DVS), Solid State Nuclear Magnetic Resonance (SSNMR) and Infrared (IR) spectroscopy were employed in this investigation to understand the root cause mechanistically. Specifically, multi nuclei SSNMR (1H, 23Na, 13C) was instrumental in delineating the components of the matrix. We identified the root cause to be an acid base reaction occurring in the DP, whereby sodium ion in sodium stearyl fumarate (SSF) is replaced by proton leading to SSF form conversion. We also identified commercially available SSF to be a hydrate that can dehydrate to an anhydrous form upon heating. In general, the same techniques can be used to investigate interactions of any multi component solid dosage forms. 相似文献
63.
Behavioral intention to prevent cervical cancer and related factors among female high school students in Japan 下载免费PDF全文
Aim
This study aimed to examine female high school students’ behavioral intention to prevent cervical cancer and related factors.Methods
The participants were 2158 female high school students at 16 high schools in A prefecture in the Tohoku region in Japan. A self‐administered questionnaire was carried out that was developed based on a conceptual framework comprising the Health Belief Model and Theory of Reasoned Action.Results
The responses were obtained from 2072 students (96.0%). Of these, the answers of 2028 respondents were analyzed after excluding those participants who did not complete the behavioral intention item (effective response rate: 97.0%). A factor analysis and covariance structure analysis yielded a model with strong goodness‐of‐fit that explained the behavioral intentions based on an “Awareness of the importance and effectiveness of cervical cancer screening,” “Obstacles to cervical cancer prevention behavior,” “Subjective norms for adopting cervical cancer prevention behavior,” and “The behavior of someone close that encourages cervical cancer prevention behavior.”Conclusion
The statistical analysis yielded a model with strong goodness‐of‐fit that explained female high school students’ behavioral intentions, which were related to four factors, including “the awareness of the importance and effectiveness of cervical cancer screening.”64.
65.
《Vaccine》2015,33(35):4307-4312
Polio is expected to be eradicated within only a few years from now. Upon polio eradication, the use of oral polio vaccines, which can cause circulating and virulent vaccine derived polio viruses, will be stopped. From this moment onwards, inactivated polio vaccines (IPV) will be used for worldwide vaccination against polio. An increased demand for IPV is thus anticipated. As a result, process development studies regarding the IPV production process, developed in the 1960s, have intensified. Studies on yield optimization aiming at costs reduction as well as the use of alternative polio viruses, which are more biosafe for manufacturing, are actual. Here our strategy to setup a new IPV production process using attenuated Sabin polio virus strains is presented. Moreover, aspects on reduction of the costs of goods and the impact of process optimization on sIPV costs are reviewed. 相似文献
66.
Karina de Oliveira Azzolin Dayanna Machado Lemos Amália de Fátima Lucena Eneida Rejane Rabelo-Silva 《Revista latino-americana de enfermagem》2015,23(1):44-50
OBJECTIVE:
to assess patient knowledge of heart failure by home-based measurement of two NOC Nursing Outcomes over a six-month period and correlate mean outcome indicator scores with mean scores of a heart failure Knowledge Questionnaire.METHODS:
in this before-and-after study, patients with heart failure received four home visits over a six-month period after hospital discharge. At each home visit, nursing interventions were implemented, NOC outcomes were assessed, and the Knowledge Questionnaire was administered.RESULTS:
overall, 23 patients received home visits. Mean indicator scores for the outcome Knowledge: Medication were 2.27±0.14 at home visit 1 and 3.55±0.16 at home visit 4 (P<0.001); and, for the outcome Knowledge: Treatment Regimen, 2.33±0.13 at home visit 1 and 3.59±0.14 at home visit 4 (P<0.001). The correlation between the Knowledge Questionnaire and the Nursing Outcomes Classification scores was strong at home visit 1 (r=0.7, P<0.01), but weak and non significant at visit 4.CONCLUSION:
the results show improved patient knowledge of heart failure and a strong correlation between Nursing Outcomes Classification indicator scores and Knowledge Questionnaire scores. The NOC Nursing Outcomes proved effective as knowledge assessment measures when compared with the validated instrument. 相似文献67.
Marcos Barragan da Silva Miriam de Abreu Almeida Bruna Paulsen Panato Ana Paula de Oliveira Siqueira Mariana Palma da Silva Letícia Reisderfer 《Revista latino-americana de enfermagem》2015,23(1):51-58
AIM:
to evaluate the clinical applicability of outcomes, according to the Nursing Outcomes Classification (NOC) in the evolution of orthopedic patients with Impaired Physical MobilityMETHOD:
longitudinal study conducted in 2012 in a university hospital, with 21 patients undergoing Total Hip Arthroplasty, evaluated daily by pairs of trained data collectors. Data were collected using an instrument containing five Nursing Outcomes, 16 clinical indicators and a five point Likert scale, and statistically analyzed.RESULTS:
The outcomes Body Positioning: self-initiated, Mobility, Knowledge: prescribed activity, and Fall Prevention Behavior presented significant increases in mean scores when comparing the first and final evaluations (p<0.001) and (p=0.035).CONCLUSION:
the use of the NOC outcomes makes it possible to demonstrate the clinical progression of orthopedic patients with Impaired Physical Mobility, as well as its applicability in this context. 相似文献68.
69.
Background
Real time 1:1 videoconferencing (VC) has the potential to play an important role in the management of orthopaedic pathologies. Despite positive reporting of telemedicine studies uptake in clinical practice remains low. Acceptability to patients is an important element of system take-up in telemedicine and a focus towards qualitative methodology may explore the underlying reasons behind its acceptability. In this paper we have systematically reviewed qualitative studies that include evidence about patient responses to VC services in an orthopaedic setting.Objectives
To determine whether real time 1:1 videoconferencing is acceptable to patients in an orthopaedic setting.Data sources
MEDLINE, AMED, PsychINFO, CINAHL, SCOPUS, Cochrane Database, Evidence Search and Open Grey were searched with forwards and backwards reference screening of eligible papers.Eligibility criteria
Qualitative studies exploring the acceptability of VC in an orthopaedic setting were included.Study appraisal and synthesis methods
Studies were appraised using the CASP tool. A Directed Content Framework Analysis was conducted using Normalisation Process Theory.Results
Four studies were included for review. The themes for the four studies did not overlap and did not report clinician acceptability of VC. The Directed Content Analysis of these papers using Normalisation Process Theory highlighted factors which contribute towards its acceptability.Conclusions
All studies concluded that the use of VC was acceptable. Further qualitative research exploring both patient and clinician acceptability is required utilising a theoretical framework to allow for repeatability and generalisability.Systematic Review Registration Number: PROSPERO CRD42015024944. 相似文献
70.
Blathin Casey Susan Coote Sara Hayes Stephen Gallagher 《Archives of physical medicine and rehabilitation》2018,99(10):2059-2075