电温针配合中药治疗膝骨关节炎临床观察

目的　观察针药结合治疗膝骨关节炎的临床疗效。方法　将 13 8例患者随机分为治疗组 85例 ,运用电温针配合中药治疗 ;对照组 5 3例 ,以西药内服治疗。经治疗 1个月后停 1个月再行观察作疗效对照。结果　治疗组总有效率 89.4% ,对照组5 6.6% ,两组疗效差别有非常显著性意义 ( P<0 .0 1)。结论　电温针配合中药治疗膝骨关节炎效果明显、确切     

玻璃酸钠与Kenacort-A联合治疗膝骨关节炎合并滑膜炎临床观察

目的探讨玻璃酸钠(SH)联合肾上腺皮质激素类药Kenacort-A关节腔内注射治疗膝骨关节炎(OA)合并滑膜炎(SY)的临床疗效。方法选膝OA合并SY患者205例,随机分为单纯用药组(100例)和联合用药组(105例),单纯用药组给予SH关节腔内注射,联合用药组给予AH+Kenacor-A关节腔内注射。结果联合用药组的起效时间及疗效明显优于单纯用药组。结论SH联合Kenacort-A治疗膝OA合并SY,疗效快,可提高临床治疗效果。     

MMP13在骨性关节炎患者滑膜细胞中的表达

目的 观察在膝关节骨性关节炎（osteoarthritis，OA）患者的滑膜细胞中是否有基质金属蛋白酶13（matrix metalloproteinases-13，MMPl3）的mRNA表达。方法 分别取临床上5例确诊为膝关节骨性关节炎患者的滑液培养滑膜细胞，经形态学和免疫组化法鉴定其为成纤维细胞后，用RT-PCR检测其中MMPl3的mRNA表达。结果 所培养的细胞呈成纤维细胞样，Vimentin蛋白表达阳性，RT-PCR可检测到MMP13的mRNA表达，片断大小和文献报道的相一致。结论 骨性关节炎患者滑膜细胞中有MMP13的mRNA表达。     

中医医院膝关节骨关节炎住院患者的治疗情况--附892份病历分析

为了解中医医院膝关节骨关节炎住院患者的治疗现状,对湖南省12家中医医院5年膝关节骨关节炎住院患者治疗情况进行调查,摘录其相关治疗资料,并进行统计学分析处理.结果显示892例中,78.8%者内服中药汤剂,19.4%外用中药,所用中药性味多为辛温,内服药以祛风湿、补虚类药物居多,外用药以祛风湿、活血化瘀类药物为主.25.1%采用针灸治疗,常用穴位有膝眼、足三里、阳陵泉、阴陵泉、血海、梁丘等.13.1%接受推拿按摩治疗,但大多数病案未记载具体手法.46.2%内服NSAIDs,19.5%使用抗生素,15.4%使用激素类药物.表明中医医院对膝关节骨关节炎住院患者常采用中西医结合方法治疗,中医治疗多为各种方法组合的综合疗法,中药多选择性味辛温之品,祛风湿药、补虚药和活血化瘀类药物为临床常用中药.     

硫酸氨基葡萄糖预防兔膝骨关节炎的实验研究

目的:观察硫酸氨基葡萄糖预防兔实验性早中期骨关节炎(OA)病变发生发展及其对软骨修复作用的程度.方法:24只新西兰白兔切断膝关节前、后交叉韧带建立兔OA模型,随机分为对照组和实验组各12只,实验组术后第9周起加服硫酸氨基葡萄糖90mg·kg-1·d-1,对照组常规饲养.术后17周处死动物,取股骨内髁负重面软骨标本进行苏木紫-伊红(HE)染色、番红O/固绿(Safranin'O/Fast Green)组织化学染色及OA评分、分级.结果:切断兔前后交叉韧带可以成功复制出OA早、中期模型,第17周时实验组OA病理评分低于对照组(P<0.05).结论:硫酸氨基葡萄糖可以较好的预防OA的发生发展,同时对兔膝OA软骨退变有较好的修复作用.     

四环素对实验性骨关节炎MMP-1、NO及PGE_2的作用

研究表明,四环素类药物可阻止胶原分解,干扰软骨细胞分化,改善软骨损伤,对骨关节炎(OA)有一定保护作用[1],但具体机制尚不清楚.OA的发生发展与多种因子如前列腺素E2(PGE2)、一氧化氮(NO) 密切相关;金属蛋白酶-1(MMP-1)是一种新型的OA标志物.     

Comparing the efficacy of different intra-articular injections for knee osteoarthritis: A network analysis

Background:The findings on the effectiveness of platelet-rich plasma, ozone, and hyaluronic acid in the treatment of osteoarthritis of the knee are controversial, and the existing original studies and meta-analyses are mostly comparisons of a single joint cavity injection method, lacking direct and indirect comparisons of different drugs in the joint cavity. The lack of direct and indirect comparisons of different drugs in the joint cavity makes it difficult to have a clearer and more comprehensive understanding of joint cavity injection methods. In this study, the efficacy of platelet-rich, ozone, sodium hyaluronate, and combined knee cavity injections were compared directly or indirectly using a reticulated meta-analysis in this field, and the efficacy of treatment measures was ranked to provide more comprehensive and reliable evidence-based clinical evidence for the selection of knee cavity injections in osteoarthritis of the knee.Objective:To compare the effects of platelet-rich plasma, ozone, and sodium glassate injection interventions on the efficacy of osteoarthritis of the knee through reticulated Meta-analysis, and to comprehensively compare the clinical effectiveness of platelet-rich plasma, ozone, and sodium glassate injection joint cavity injection for the treatment of osteoarthritis of the knee.Methods:The PubMed, CBM, CNKI, VIP, and Wan-Fang databases were searched for information on the effectiveness of platelet-rich plasma, ozone, and sodium vitrate injection for the comparative treatment of osteoarthritis of the knee, with a search time frame of each database from the date of creation to July 20, 2021. Two investigators independently screened the literature, extracted data according to inclusion and exclusion criteria, and evaluated the quality of the literature in parallel. Statistical analysis was performed using Stata 16.0 software to compare the differences in the efficacy of each treatment measure using the ratio and 95% confidence interval as effect indicators and to rank the efficacy.Results:Thirty-three RCTs with 7003 patients with osteoarthritis of the knee were included, involving 5 therapeutic measures. Meta-analysis showed that the efficacy of platelet-rich plasma injection was superior to both ozone and hyaluronic acid therapies. Hyaluronic acid+ozone and platelet-rich plasma+hyaluronic acid were both superior to ozone and hyaluronic acid monotherapy. The differences in efficacy between hyaluronic acid and ozone compared with platelet-rich plasma were statistically significant, and the differences in efficacy between the 2 combination therapies (platelet-rich plasma+hyaluronic acid, hyaluronic acid+ozone) and the 3 monotherapies (platelet-rich plasma, ozone, hyaluronic acid) were statistically significant. Platelet-rich plasma+hyaluronic acid, hyaluronic acid+ozone compared with 3 monotherapies (platelet-rich plasma, ozone, hyaluronic acid) were statistically significant, except for the difference in efficacy with platelet-rich plasma, which was not statistically significant, indicating that this platelet-rich plasma+hyaluronic acid and Hyaluronic acid+ozone combination therapy was superior to monotherapy. Also, the efficacy of platelet-rich plasma was better than hyaluronic acid and ozone and the difference was statistically significant, indicating that platelet-rich plasma was more effective than ozone and sodium glass in the treatment of osteoarthritis of the knee in monotherapy.Conclusion:It is believed that in the course of clinical practice, hyaluronic acid+ozone or platelet-rich plasma+hyaluronic acid combination therapy or platelet-rich plasma therapy can be preferred for patients with osteoarthritis of the knee.     

膝骨关节病性髁间窝撞击症的镜下诊断与治疗

目的 探讨膝骨性关节炎合并股骨髁间窝撞击症的诊断和治疗方法.方法 关节镜下确诊合并股骨髁间窝撞击症的膝骨性关节炎患者37例43膝.采用镜下清理骨赘、股骨髁间窝扩大成形术治疗.结果 43膝均获随访,时间6～24个月.术前Lysholm评分平均61分(41～80分) ,术后平均85分(75～100分),关节功能均获明显改善(P＜0.05).结论 关节镜检查及镜下微创手术对膝骨关节病性髁间窝撞击症的诊断和治疗有着重要的价值,镜下股骨髁间窝扩大成形术是治疗该病的有效方法.     

破骨细胞分化在颞下颌关节骨关节炎发生中的作用

目的 探究破骨细胞分化在颞下颌关节骨关节炎(TMJOA)发生中的作用.方法 构建小鼠TMJOA模型,Micro-CT观察TMJOA发生发展过程中髁突骨质变化,苏木素伊红(HE)染色观察TMJOA关节组织学结构变化,抗酒石酸酸性磷酸酶(TRAP)组织染色观察TMJOA关节组织中破骨细胞的存在情况.收集TMJOA患者滑液,...     

The Effect of Self-Myofascial Release on the Pennation Angle of the Vastus Medialis Oblique and the Vastus Lateralis in Athletic Male Individuals: An Ultrasound Investigation

BackgroundMaintenance of patellar stability requires a balance between the vastus medialis oblique (VMO) and the vastus lateralis (VL). The imbalance between these muscles is thought to be implicated in the etiology of patellofemoral pain (PFP). Where there is hypertrophy of the VL in PFP patients, self-myofascial release (SMR) may be utilized for its management. However, there is no current evidence regarding SMR and its effects on VMO and VL architecture. The aim of this study, therefore, was to use ultrasound to gain further understanding of the effects of a program of SMR on the fiber angles of the VMO and VL.HypothesisThere will be a significant decrease in the pennation angles of the VMO and VL after seven weeks of SMR using a foam roller.Study DesignCohort StudyMethodsTwenty-five young, athletic, male participants were recruited to use a foam roller, along the full length of both anterior thighs, three times weekly, on three separate days, for seven weeks. Ultrasound was used to determine the initial and final VMO and VL pennation angles on both limbs. One eligible participant was chosen as an intra-rater control and did not partake in the SMR regimen.ResultsThere was a statistically significant (p < 0.001) decrease in the pennation angles of the VMO and VL after the SMR regime. Mean combined right and left VL angle change was -6.65° (-18% mean change) and the mean combined right and left VMO angle change was -7.65° (-11.5% mean change). A weak negative correlation was found between initial VMO fiber angle and the angle change (Rsquared = -0.21), as well as moderate negative correlation for the VL (Rsquared = -0.51).ConclusionA program of SMR on the anterior thighs of young, asymptomatic males resulted in changes to the fiber angles of both the VMO and VL. There was a significant decrease in pennation angle after seven weeks of SMR using a foam roller.