肺与大肠相表里新解

从肺与大肠的进化发育关系、神经－内分泌－免疫网络探析肺与大肠相表里的实质。认为，肺与大肠有共同的发育学基础，其密切的神经、免疫联系可能是两生理病理相关的物质基础，具体的联系途径值得进一步研究。     

Kidneys for Sale: Who Disapproves,and Why?

The shortage of transplant kidneys has spurred debate about legalizing monetary payments to donors to increase the number of available kidneys. However, buying and selling organs faces widespread disapproval. We survey a representative sample of Americans to assess disapproval for several forms of kidney market, and to understand why individuals disapprove by identifying factors that predict disapproval, including disapproval of markets for other body parts, dislike of increased scope for markets and distrust of markets generally. Our results suggest that while the public is potentially receptive to compensating kidney donors, among those who oppose it, general disapproval toward certain kinds of transactions is at least as important as concern about specific policy details. Between 51% and 63% of respondents approve of the various potential kidney markets we investigate, and between 42% and 58% want such markets to be legal. A total of 38% of respondents disapprove of at least one market. Respondents who distrust markets generally are not more disapproving of kidney markets; however we find significant correlations between kidney market disapproval and attitudes reflecting disapproval toward certain transactions—including both other body markets and market encroachment into traditionally nonmarket exchanges, such as food preparation.     

Innovation in Chemistry,Manufacturing, and Controls—A Regulatory Perspective From Industry

This review describes the landscape of novel modalities such as cell and gene therapies, viruses, other novel biologics, oligomers, and emerging technologies, including modern analytics. We summarize the regulatory history and recent landmark developments in some major markets and examine specific chemistry, manufacturing, and controls (CMC) challenges, including suggestions for exploration of potential science-based approaches in support of regulatory strategy development from an industry perspective. In addition, we evaluate the economic factors contributing to patient access to innovation and discuss the impact of regulation. There is a desperate need for a consistent form of regulation where global approaches to regulatory strategies can be harmonized, and specific CMC challenges can be dealt with using the appropriate science and risk-based tools. Although these tools are well described in current guidance documents, the specifics of applicability to complex novel modalities can still result in differing regulatory advice and outcomes. The future goals for efficiently regulating innovative modalities and technologies could be aided by more regulatory harmonization, regulatory education, and industry cooperation through consortia, enabling industry to supply key information to regulators in a transparent yet well-defined manner, and utilizing mutually understood risk-benefit analyses to produce drugs with appropriate safety, efficacy, and quality characteristics.     

中医肾与现代西医学组织器官的相关性研究

对古代医案进行Logistic回归分析 ,找到对中医肾病及其证候最重要的病因或病理结果、症状和用药。根据中、西医学研究对象 (人体 )的一致性 ,寻找这些病因或病理结果、症状和用药的西医学解释 ,发现与中医肾直接相关的西医学组织器官主要是泌尿系统、生殖系统和支配两系统的神经系统。另外 ,肾上腺、甲状腺、呼吸系统、耳、腰骶部的骨和软组织等也与中医肾有密切关系。     

中药治疗缺血性脑卒中致多器官损伤的研究进展

缺血性脑卒中(cerebral ischemic stroke,CIS)可引发包括心、肝、脾、肺、肾在内的多个器官损伤,该类疾病是由多个病理环节组成,具有复杂的发病机制及高发病率、高致残率和高死亡率的特点,严重者可形成多器官功能障碍综合征(multiple organ dysfunction syndromes,MOD...     

Clinical and Biomarkers Difference in Prepartum and Postpartum Eclampsia

Background

There is a large body of literature which assessed the incidence and risk factors of eclampsia, but little was done in assessing the association of clinical features and biological markers with prepartum and postpartum eclampsia.

Methods

A total of 361 eclamptic women admitted to three teaching hospitals between 2008 and 2013 were included in this analysis. A comparative analysis was done for several clinical and biological variables to assess their association with prepartum and postpartum eclampsia.

Results

The overall incidence of eclampsia was 1.2% (prepartum 71% and postpartum 29%). The majority of women with prepartum eclampsia were young, primigravida, more hypertensive, symptomatic and proteinuric. Conversely, the majoritys of the women with post-partum eclampsia were adult, multiparous, carrying pregnancy to term, anemic, thrombocytopenic, and with hepatic dysfunction. The commonest severity symptom (headache) was less common in postpartum eclamptic women.

Conclusion

The incidence of eclampsia was among the highest in the world. And, the analysis has shown that the clinical and biochemical spectrum of prepartum and postpartum eclampsia were apparently different. The majority of the women who developed postpartum eclampsia were multiparous and adult. Derangement of biomarkers was also more common in women with postpartum eclampsia.     

辨三焦形质

三焦包括多种不同的组织,性质多样,且在皮肤、肌肉、脏腑之间无处不在,既独立存在又遍布全身,为联络脏腑官窍的一个庞大复杂的网络组织。具有运行水液,通行元气及“游行相火”、“运清泻浊”之功,与现代医学的机体内环境即细胞外液有很大的相似性。     

艾灸与针刺五脏背俞穴治疗CSF临床疗效对比观察

目的:观察艾灸及针刺五脏背俞穴治疗慢性疲劳综合征的临床疗效。方法:通过随机对照的方法,对60例慢性疲劳综合征的患者的临床观察,艾灸组以艾炷灸五脏背俞穴治疗,针刺组以针刺五脏背俞穴治疗。结果:治疗后两组患者《疲劳评定量表》积分值与治疗前相比均有显著降低,具有极显著性差异(P0.01),疗效显著。两组患者组间整体症状体征改善情况差异比较P0.05,差异无统计学意义,两组治疗方案在临床症状总体改善方面疗效相同。单个症状改善上各具优势。结论:本课题研究采用艾灸及针刺五脏俞治疗CFS取得显著疗效,两者疗效相同,但在单项症状改善方面各有优势。     

调畅五脏、调和营卫治疗自汗临证体会

通过分析汗与五脏、营卫的关系,探讨自汗证的病因病机,概括为五脏皆有汗,汗之本为心,汗之化为肾,汗之出为肺,汗之源为脾胃,汗之调为肝。又必以营卫调和为要,汗出方能有节。五脏功能失调、营卫失和均可致自汗。故提出“调畅五脏、调和营卫”的自汗证治则及处方用药,通过典型临床病案,进一步阐释诊疗思路及用药规律。     

针灸治疗中风后偏瘫肩痛随机平行对照研究

[目的]观察针灸治疗中风后偏瘫肩痛疗效。[方法]使用随机平行对照方法,将74例住院患者按随机数字表法分为三组。针灸组25例取人中、患侧极泉、足三里、三阴交、涌泉、内关、绝骨及通里穴位,相互配合,交替循环使用1.5寸30号毫针,直刺,小幅度提、插、捻、转;极泉穴不留针,其余穴位得气后留针30min,1次/d。中药组25例辨证分型,肝阳上亢、上扰风火天麻钩藤饮;瘀血风痰、脉络阻滞疏通脉络汤;热痰腑实、风痰干扰星萎承气汤。1剂/d,水煎450mL,每次取150mL,早晚饭前空腹服用。针灸中药组24例针灸联合中药。连续治疗5d为1疗程,休息2d,进行下1疗程。观测临床症状、不良反应。连续治疗4疗程,判定疗效。[结果]针灸组基本痊愈12例,显效10例,有效2例,无效1例,总有效率96.00%。中药组基本痊愈2例,显效5例,有效10例,无效8例,总有效率68.00%。针灸中药组痊愈10例,显效9例,有效1例,无效4例,总有效率83.30%。针灸组、针灸中药组优于中药组（P〈0.05）。[结论]针灸治疗中风后偏瘫肩痛效果显著,值得推广。