Associations of vitamin D status and metabolic dyslipidemia and hypertriglyceridemic waist phenotype in apparently healthy adults

Background

Recent studies have shown that Vitamin D deficiency is very common globally. Vitamin D deficiency is associated with lipid metabolism. A relationship between vitamin D levels and waist circumference (WC) has been observed. The purpose of this study is to evaluate the relationship between vitamin D status and metabolic dyslipidemia and the hypertriglyceridemic waist phenotype.

Trabecular and cortical bone changes in vertebral and peripheral skeletons induced by surgical menopause

Using dual x-ray absorptiometry (DXA), quantitative computed tomography (QCT), and microdensitometry (MD) methods, we performed a 3-year longitudinal study of bone changes induced by surgical menopause, i.e., hysterectomy with unilateral or bilateral oophorectomy (OVX), in 52 nonmenopausal women. In the trabecular spine, bone mineral content (D_c) and bone mineral density (D_d) were determined by DXA, and bone mineral density (L₂ and L₃) was determined by QCT. In the cortical metacarpals, cortical thickness (MCI) and bone mineral density (GSmin/max and ∑ GS/D) were determined by MD. Bone reduction in axial and peripheral body sites was evaluated by all determinations 2.92 years after OVX. In the bilateral OVX group, accelerated bone changes began to appear immediately after OVX, and this rapid phase of bone loss persisted in the follow-up period. In the unilateral OVX group, however, no accelerated changes were detected and the slow phase of bone loss continued throughout the follow-up period; bone reduction in the bilateral group was thus greater than that in the unilateral group. Although there was a significant correlation between trabecular and cortical bone changes, the discrepancies between DXA, QCT, and MD determinations at the two body sites meant that it was not possible to precisely predict one bone measurement from another. The reliability of DXA and QCT determinations was not significantly different, and these two determinations afforded better discrimination than MD for detecting accelerated trabecular bone changes in the rapid phase early after OVX. The sensitivity of indices in MD for detecting cortical bone mass change was found to be, in descending order, MCI, GSmin/max, and ∑ GS/D, whereas on the MD determination, the sensitivity for the follow-up of bone changes was in the reverse order. MD was more suitable for discriminating the small cortical bone changes in the prolonged slow phase after OVX. To evaluate the influence of surgical menopause by determining differential trabecular and cortical bone changes, simultaneous assessment at both vertebral and peripheral sites was indispensable. Changes in the peripheral metacarpals did not prove to be a reliable indicator of changes in the axial spine.     

烹饪油烟对大鼠SOD、MDA及免疫器官影响的研究

目的 :研究烹饪油烟对大鼠血清 SOD (超氧化物歧化酶 )活性、MDA (丙二醛 )含量及免疫器官的影响。方法 :给大鼠分别经腹腔一次注入 80 0 0 mg/ kg、 40 0 0 mg/ kg、 2 0 0 0 mg/ kg的烹饪油烟凝集物 ,同时设对照组 ,6d后颈动脉取血并处死动物 ,测定血清中 SOD活性、 MDA含量 ,观察对免疫器官的影响。结果 :烹饪油烟可使大鼠血清中 SOD活性显著降低 ,MDA含量明显升高 ,与对照组比较 P<0 .0 5及 P<0 .0 1,并对胸腺和脾脏产生不同程度的病理损伤。结论 :烹饪油烟可破坏机体氧化与抗氧化的动态平衡 ,并损及机体免疫器官的结构和功能     

Aortocoronary bypass surgery: Correlation of angiographic symptomatic and functional improvement at 1 year.

Angiographic changes in the coronary circulation were evaluated in 60 patients 1 year after aortocoronary bypass surgery, and their relation to the postoperative clinical status was examined. Of 124 grafts implanted, 26 were closed, 7 stenotic and 91 (74 percent) patent at 1 year. Progression of occlusive disease occurred in 21 of 57 (37 percent) nongrafted and 78 of 123 (63 percent) grafted vessels. On the basis of location and severity of progression, significant lesions bypassed and patency of grafts, postoperative coronary perfusion was considered optimal in 16 patients (Group I), better in 24 (Group III). Complete freedom from chest pain or lessening of pain (improvement by two New York Heart Association functional classes) occurred in 88 and 79 percent of patients in Group III. Positive preoperative treadmill stress tests became negative after surgery in five of six patients in Group I, five of eight in Grojp II and three of eight in Group III. This study demonstrates that when progression of disease, graft patency and extent of revasculariztion are considered in combination, the postoperative angiographic status of the coronary circulation correlates well with clinical improvement at 1 year. These findings support the hypothesis that improved blood supply to ischemic myocardium is a major factor contributing to relief of angina pectoris after saphenous vein bypass surgery.     

Clinical efficacy and electrophysiology of oral propafenone for ventricular tachycardia

Sixteen patients with ventricular tachycardia (VT) or nonfatal cardiac arrest were treated with propafenone (P), 900 mg/day. Electrophysiologic studies were performed before and during therapy with P. All patients had inducible sustained VT at the baseline study. During P therapy, VT was not inducible in 1 patient, was unsustained in 1 and was harder to induce in 2 patients. P increased the cycle length of VT from 307 ± 67 to 382 ± 107 ms. Five patients began outpatient therapy with P, including 2 in whom VT was slowed to < 125 beats/min. Two are arrhythmia-free during follow-up of 2 and 8 P significantly increased intraatrial conauction time (from 44 ± 12 to 72 ± 22 ms), AH interval (from 115 ± 36 to 152 ± 45 ms), HV interval (from 55 ± 18 to 92 ± 42 ms), QRS duration (from 140 ± 36 to 180 ± 48 ms) and QT interval (from 402 ± 30 to 459 ± 60 ms). P increased atrial (from 247 ± 36 to 288 ± 38 ms) and ventricular (from 249 ± 20 to 277 ± 32 ms) effective refractory periods, Sinus cycle length did not change, but the corrected sinus node recovery time increased (from 162 ± 85 to 821 ± 1,607 ms). P aggravated arrhythmias in 4 patients. The plasma P concentration, measured either at the time of electrophysiologic studies or when therapy was discontinued, was 753 ± 428 ng/ml. P suppressed ventricular ectopic beats in 33 % and increased them in 1 patient. P has antimonths. arrhythmic activity against VT similar to that of other antiarrhythmic drugs and has potential for serious adverse effects in some patients.