COMMENTS ON THE HOLISTIC ACTION OF ACUPUNCTURE IN VIEW OF ITS INFLUENCE ON NERVE-ENDOCRINE-IMMUNE NETWORK

In the present paper, the author makes some comments on the holistic action of acupuncture from the regulative effect on the nerve-endocrine-immune network, and the close relationship between the nerve-endocrineimmune network and the meridian-collateral system of TOM. The wholism concept of TOM refers to the organism being an integrated entirety, and the regulatory effect of acupuncture on functional activities of the organism relies on the integral connection of the acupoint--meridian-collateral-zangfu-organ system. When stimulated with acupuncture, the human body will brings its potential force into full play in preventing and treating diseases.     

银环蛇毒素对白血病K562细胞株凋亡诱导作用的研究

目的 探讨银环蛇毒素及其若干组分在体外对白血病K562细胞株的凋亡诱导作用。方法 采用阳离子交换层析法分离纯化银环蛇粗毒，应用MTT法、荧光显微镜和流式细胞术等研究毒素对K562细胞株的凋亡作用。结果 除Ⅳ峰毒素外，银环蛇粗毒及分离的部分组分IV峰、Ⅶ峰和Ⅷ峰等毒素的荧光显微图末见特征性的凋亡小体，DNA含量分布组方图中的二倍体峰前末见Gl细胞群。结论 银环蛇毒对K562细胞具有杀伤作用，但并非是细胞凋亡作用，而是致细胞坏死，而粗毒中的某些组分可能具有促K562细胞凋亡作用。     

十八甲基炔诺酮透皮控释传递系统在人体不同部位皮肤的药物动力学

6名健康妇女分别于上臂、臀部和腹部三部位经皮给予合LNG的透皮控释传递系统（TCDS）后，用放射免疫法测定LNG血清浓度，计算其主要药物动力学参数。结果表明：在TCDS用药期间，三部位的C（max）、T（max）及AUC（0～168h）基本接近，部位间无显著性差异（P＞0．05）；TCDS揭除后，AUC（168～204h）及消除相半衰期T（1／2）（Ke）均以腹部最大，臀部次之，上臂最小，在腹部与上臂间有显著性差异（P＜0．05）。上述结果可归因于TCDS对LNG的控释和人体皮下脂肪的“贮库效应”。     

THERAPEUTIC EFFECTS OF ACUPUNCTURE TREATMENTIN 96 CASES OF TRIGEMINAL NEURALGIA

Thetrigeminalnervebranchesofftheoph-thalmic,mandibularandmaxillarybranchesfromthesemilunarganglion,whicharemainsensorynerveslnnervatingtheheadandtheface.Ifanyonebranchoftheminthedistribu-tionregionsofthetrigeminalnerveisaffectedbywind-cold,pressureorinflammatorystimulation,etc.,abnormalsensationorpainwillbeinducedinthecorrespondinginnervatedregion.Clinical-ly,patholOgicchangeoftheophthalmicbranchismorecommonandmaycausepainoftheorbitandtheforehead,andlacrimation;Patientswithpainofthemaxillarybr…     

中西医结合治疗急性白血病存活十年以上5例

中西医结合是提高急性白血病长期存活的有效途径。笔者采用中药与化疗相结合的方法治疗３００余例急性白血病患者中，５例存活长达１０年以上，最长１例已存活２０年，至今皆高质量健康生存。现代药理学研究表明部分中药具有良好的抗白血病作用。     

Acute bronchodilatory effect of salmeterol on methacholine-induced bronchoconstriction in childhood asthma

Abstract A review of the literature highlights the need for research, particularly on the acute bronchodilatory effect of salmeterol on bronchoconstriction in the pediatric age group. The present study attempted to evaluate the acute bronchodilatory effect of salmeterol on methacholine-induced bronchoconstriction in childhood asthma and to compare it with the effect of salbutamol. Forty-four asymptomatic children with mild-to-moderate asthma (23 boys and 21 girls; aged7–17 years) were studied. At the beginning, the baseline forced expiratory volume in 1 s (FEV₁) was measured, and the methacholine challenge was performed by doubling the dose to determine PC₂₀ (provocative concentration of inhaled methacholine required to reduce FEV! by 20%). At the same time, the transcutaneous arterial oxygen saturation (S_ao₂) was also measured. Each subject inhaled a single dose of 25 μ salmeterol (n: 23, group I) or 100 μg salbutamol (n: 21, group II) following the Sp₂ measurement. The same measurements (FEV₁, S_ao₂) were repeated 5 and 20 min after the inhalation. After inhalation of salmeterol or salbutamol, the differences between the values of FEV₁ and S_aO₂ after 5 and 20 min were insignificant in both group I and group II (P > 0.05), although there was a significant improvement in both FEV₁ and S_aO₂ after 5 and 20 min (P < 0.005). From these findings it was concluded that salmeterol can be considered as effective as salbutamol on methacholine-induced bronchoconstriction.     

Fatty acid balance studies in term infants fed formula milk containing long-chain polyunsaturated fatty acids

Long-chain polyunsaturated fatty acids (LCP) are thought to be required for optimal nervous system development in the newborn. A commercial milk formula containing LCP (Aptamil-LCP) with a fatty acid profile closely resembling breast milk, has recently been introduced for term infants. The absorption of fatty acids in term infants was examined in a double-blind randomized controlled trial comparing Aptamil-LCP ( n = 20) and standard Aptamil ( n = 20). Formula-fed newborn infants were studied from birth for 14 d. Fat balances (3 d) were performed from d 10. A 3-d stool collection was performed from d 10 in a parallel breastfed group ( n = 21). Plasma samples were taken on d 6. Median fat excretion (mg kg⁻¹) was 897.1, 615.0 and 355.2 with Aptamil, Aptamil-LCP and breastfeeding, respectively. The median total fat absorption coefficient in Aptamil-LCP-fed infants was higher than in those fed standard Aptamil ( p < 0:01). These findings were accounted for by differences in the excretion and absorption of long-chain saturated fatty acids (C14:0, C16:0 and C18:0). Higher fat excretion was associated with bulkier and firmer stools. Only trace amounts of LCP were detected in the stools of all groups. This accounted for less than 4% of dietary intake in Aptamil-LCP-fed infants. No differences in the utilization of LCP from Aptamil-LCP and breast milk feeding were apparent. Plasma phospholipid fatty acid composition data reflected differences in dietary LCP intake. Thus, PL LCP levels were highest in the breastfed infants and lowest in the Aptamil-fed infants, with values for the Aptamil-LCP-fed group falling in between.     

仙龙冲剂的抗肿瘤活性及其作用机理的研究

目的:研究仙龙方的体内、体外抑癌作用及机理。方法:用 BALB/C 小鼠,荷肝癌和艾氏癌实体瘤,经口给药,观察肿瘤的抑制程度和动物的生存状况。结果:给药组肿瘤生长曲线明显低于对照组。仙龙方还能延长荷瘤动物的生存期,生命延长率为30%～69%。体外实验显示仙龙方对人癌细胞的抑制有一个良好的剂量—效应关系,肝癌的曲线之回归系数 r=0.9983,IC_(50_值为14.8±2.8μg/ml;胃癌曲线的系数 r=0.9995,IC_(50)值为9.7±5.1μg/ml,表明胃癌细胞更敏感些。细胞学研究发现癌细胞的不同程度的损伤、核染色质的凝聚现象及内质网肿胀,流式光度术分析 DNA 组方图上出现了凋亡峰。结论:仙龙方有诱导癌细胞凋亡作用。     

中西医结合治疗溃疡性结肠炎经验

溃疡性结肠炎(UlcerativeColitis UC)又称非特异性结肠炎,是一种病因尚不十分清楚的直肠和结肠慢性非特异性炎症性疾病.其病变主要限于大肠粘膜和粘膜下层,临床表现为腹泻、黏液脓血便、腹痛等,是临床常见的疑难杂症之一.笔者从2003年3月～2005年6月应用四神丸治疗该病48例,效果满意.     

针刺取穴与骨折愈合疗效关系初探

目的:初步探讨针刺取穴与骨折愈合疗效的关系,为临床研究和应用提供参考,方法选用48只体重2.0～2.5 kg的雄性纯种大耳白家兔,手术造成新鲜桡骨骨折模型,用区组随机法分为局部和邻近取穴组(A组)、远道和辨证取穴组(B组)、局部和邻近取穴加远道和辨证取穴组(C组)、空白对照组(D组)共四组,术后第一天开始对治疗组分别做电针治疗,于术后7 d、14 d、28 d取材做血液生化学、生物力学、放射学、组织学的观测.比较各组间上述指标的差别.结果:血清碱性磷酸酶含量14 d时A组和C组明显高于B组和D组(P＜0.01),骨折标本抗弯强度在28 d时A组和C组明显高于B组和D组(P＜0.01),X线量化评分14 d和28d时A组和C组明显高于B组和D组(P＜0.05),在各个时段各个指标A组与C组、B组与D组比较均无显著差异(P>0.05).结论:局部和邻近取穴能明显促进骨折愈合,而且具有操作简便,易于推广等优点,远道和辨证取穴则效果不明显,与前者合用也没有明显增强前者的疗效.