First 100 Cases With Doppler-Guided Hemorrhoidal Artery Ligation

Purpose This study was designed to examine the benefits of a Doppler-guided hemorrhoidal artery ligation technique in terms of surgical outcome, functional recovery, and postoperative pain. Methods Using local, regional, or general anesthesia, 100 patients with symptomatic Grades II or III hemorrhoids underwent sonographic identification and suture ligation of six to eight terminal branches of the superior rectal artery above the dentate line. Visual Analog Scales were used for postoperative pain scoring. Surgical and functional outcomes were assessed at 6 weeks and 3, 6, and 12 months after surgery. Results There were 42 (42 percent) males and 58 (58 percent) females (mean age, 42 years; median duration of symptoms, 6.3 years). The mean operative time was 19 minutes. Local anal block combined with intravenous sedation (n = 93) or general or spinal (n = 7) anesthesia was used. Only five were hospitalized overnight. There was no urinary retention, bleeding, or mortality in the immediate postoperative course. The mean pain score decreased from 2.1 at two hours postoperative to 1.3 on the first postoperative day. All patients had a complete functional recovery by the third postoperative day. Ninety-four patients remained asymptomatic after a mean follow-up of six months: four patients required additional surgical excision, and two required rubber band ligations for persistent bleeding. On follow-up, there was no report of incontinence to gas or feces, fecal impaction, or persistent pain. Conclusions Our experience indicates that Doppler-guided hemorrhoidal artery ligation is safe and effective and can be performed as an outpatient procedure with local or regional anesthesia and with minimal postoperative pain and early recovery. Reprints are not available.     

内镜下套扎治疗晚期血吸虫病食道静脉曲张破裂出血68例

目的 探讨内镜下套扎治疗晚期血吸虫病食道静脉曲张破裂出血的效果。方法 130例晚期血吸虫病食道静脉曲张破裂出血住院患者随机分成2组,治疗组68例接受急诊内镜下套扎治疗,对照组62例给予常规内科治疗。观察各组继续出血率及静脉曲张红色征消失情况等,并进行比较。结果 治疗组继续出血率为10.3%,静脉曲张红色征阳性率为8.8%,均优于对照组,差异有统计学意义（P均＜0.01）。结论 内镜下套扎治疗是晚期血吸虫病食道静脉曲张破裂出血的一种有效止血方法。     

肝硬化食管静脉曲张破裂出血序贯治疗的临床应用价值

目的 评价曲张静脉套扎术(EVL)+不同硬化剂曲张静脉硬化术(EVS)序贯治疗肝硬化食管静脉曲张破裂出血的疗效及安全性.方法 回顾性总结314例肝硬化食管静脉曲张破裂出血内镜治疗患者的临床资料,包括单纯EVL治疗者112例(EVL组)、单纯鱼肝油酸钠硬化治疗者48例(EVS1组)、单纯聚桂醇硬化治疗者40例(EVS2组)、套扎+鱼肝油酸钠硬化序贯治疗者26例(EVLS1组)、套扎+聚桂醇硬化序贯治疗者88例(EVLS2组),统计各组曲张静脉治疗有效率、静脉曲张复发率、并发症发生率并进行对比分析.结果 EVL组、EVS1组、EVS2组、EVIS1组、EVLS2组曲张静脉治疗有效率比较差异均无统计学意义[85.7％ (96/112)、83.3％ (40/48)、92.5％ (37/40)、92.3％(24/26)、94.3％ (83/88),P＞0.05],但EVLS1组和EVLS2组曲张静脉完全消失率均明显高于其他3组[88.5％(23/26)和87.5％(77/88)比58.0％(65/112)、62.5％(30/48)、70.0％(28/40),P＜0.05],而EVLS1组与EVLS2组比较差异无统计学意义(P＞0.05).EVS1组再出血率最高(18.8％,9/48) (P ＜0.05),其次是EVL组(11.6％,13/112),均高于EVS2组、EVLS1组和EVLS2组[7.5％(3/40)、7.7％ (2/26)、6.8％ (6/88),P＜0.05],后3组再出血率相似(P＞0.05).治疗后随访6 ～18个月,EVL组静脉曲张复发26例(23.2％,26/112),EVS1组复发8例(16.7％,8/48),EVS2组复发6例(15.0％,6/40),EVLS1组复发4例(15.4％,4/26),EVLS2组复发9例(10.2％,9/88);EVL组复发率最高(P＜0.05),EVLS2组复发率最低(P＜0.05),EVS1组、EVS2组和EVLS1组复发率相似(P＞0.05).EVS1组总体并发症发生率(32.2％,49/152)明显高于其他4组(P＜0.05),而EVL组(14.5％,32/220)、EVLS2组(19.6％,22/112)、EVLS1组(22.7％,25/110)、EVLS2组(15.8％,34/229)4组间比较差异无统计学意义(P＞0.05).结论 EVL+鱼肝油酸钠EVS或+聚桂醇EVS序贯治疗肝硬化食管静脉曲张破裂出血是安全而有效的,尤以EVL+聚桂醇EVS序贯治疗效果显著,有可能成为治疗食管静脉曲张出血并防止再出血的最佳选择.     

内镜下套扎术联合药物治疗食管静脉曲张出血的疗效观察

目的观察内镜下食管静脉曲张套扎术联合药物治疗肝硬化食管静脉曲张出血的临床疗效。方法回顾性分析2007年2月-2010年8月56例确诊为肝硬化食管静脉曲张出血患者,随机分为联合治疗组和对照组,各28例。对照组行胃镜下套扎术联合生长抑素、泮托拉唑;联合治疗组行内镜下套扎术联合生长抑素、泮托拉唑、普萘洛尔等药物治疗。观察所有食管静脉曲张出血患者1、3、6、12、18个月后随访,两组近期再出血率、食管曲张静脉消失率及复发率、不良反应及并发症的情况。结果联合治疗组曲张静脉消失率、不良反应及并发症与对照组比较,差异无统计学意义(P>0.05);联合治疗组近期再出血及食管静脉曲张复发等发生率明显低于对照组,差异有统计学意义(P<0.05)。结论食管静脉曲张套扎术联合药物是治疗食管静脉曲张出血一种安全有效的方法,疗效确切,提高了患者生存率。     

Effect of intestinal lymphatic circulation blockage in two-hit rats

INTRODUCTION Multiple organ dysfunction syndrome (MODS) is a common but poorly understood complication in a variety of critical illnesses[1-3]. In recent years, much attention has been paid to the study of MODS, and encouraging progress has been achieved.…     

基于邻位连接技术（PLA）的生物检测新策略

邻位连接技术（PLA）是近年来发展起来的一种蛋白质检测方法。该技术的核心理念来源于适体技术、连接酶技术和Taqman探针技术,其主要形式包括均相、固相和原位3种。PLA具有特异、灵敏、快速、高通量和多功能等优点,不但能够检测蛋白质、亚细胞结构和细胞等生物样本,还能检测大分子间的相互作用,现已逐步被应用于医学和生物学等众多领域。     

后腹腔镜下肾蒂淋巴管结扎治疗乳糜尿106例围手术期护理

目的:探讨后腹腔镜下肾蒂淋巴管结扎术治疗乳糜尿的护理方法。方法:对2005年7月～2011年12月我科106例行后腹腔镜下肾蒂淋巴管结扎术的乳糜尿患者在围手术期所采取的护理措施进行总结。结果:经过术前充分做好准备,术后严密加强病情观察,并积极处理并发症,认真做好健康教育护理,106例乳糜尿患者均平稳度过围手术期,术后随访无复发。结论:充分的术前护理准备,精心的术后护理,细心的并发症观察,完善的健康教育是后腹腔镜下肾蒂淋巴管结扎术治疗乳糜尿患者平稳度过围手术期的重要保证。     

温馨提示卡应用于内镜下套扎术患者的效果观察

目的：探讨温馨提示卡在内镜下套扎术患者中的应用效果。方法将108例内镜下套扎术患者随机分为实验组和对照组,每组各54例。对照组进行常规护理,实验组在此基础上加用温馨提示卡,对2组患者的住院天数和疼痛程度进行比较。结果实施不同护理模式后,实验组患者住院天数明显少于对照组（P〈0.01）,疼痛程度显著低于对照组（P〈0.01）。结论将温馨提示卡运用于套扎术患者的护理过程中,能使患者感受到温暖,从而主动配合手术。     

脱氢枞胺钾盐对实验性胃溃疡的治疗作用

目的：研究脱氢枞胺钾盐对多种实验性动物胃溃疡的影响。方法：通过测定红细胞计数、弥漫性出血点、溃疡面积、胃液量、胃酸值、胃蛋白酶活性等指标的变化,观察脱氢枞胺钾盐对各种实验性溃疡的影响。结果：脱氢枞胺钾盐能明显降低溃疡指数。结论：脱氢枞胺钾盐对多种类型胃溃疡有抑制和治疗的作用。     

High-resolution CT Findings Suggest a Developmental Abnormality Underlying Superior Canal Dehiscence Syndrome

Objective--Patients with superior canal dehiscence (SCD) syndrome experience vertigo and oscillopsia with loud sounds and/or stimuli that result in changes in middle ear or intracranial pressure. Findings on temporal bone CT were analyzed to determine if a developmental abnormality is associated with the syndrome. Material and methods--Temporal bone CT scans [0.5 mm collimation and projections into the superior semicircular canal (SC) plane] were used to compare the bone overlying the SC in patients with SCD syndrome (20 unilateral, 7 bilateral) and in 88 patients without SCD syndrome who had undergone temporal bone CT for evaluation of other otologic disorders (controls). Results--The thickness of bone overlying the SC in the controls measured 0.67±0.38 mm (mean±SD). For individual control subjects, the thickness of bone on one side was correlated with that on the other side (r=0.43; p&;lt;0.0001). The thickness of bone overlying the SC on the intact side in patients with unilateral dehiscence measured 0.31±0.23 mm, and was thinner than that noted in the controls (p&;lt;0.0001). Conclusions--These findings support the notion that there is a developmental abnormality underlying SCD syndrome. When dehiscence is found on one side, the contralateral side is likely to be thin.