The role of PGE2 in the sensitization of mechanoreceptors in normal and inflamed ankle joints of the rat

Summary The role of PGE₂ in the sensitization of highthreshold tarsal joint mechanoreceptors (putative nociceptors) has been investigated in 11 arthritic and 16 normal rats. Injections of a low dose of Freund's complete adjuvant at multiple sites into the tissues surrounding the ankle joint induced a chronic unilateral monoarthritis in the injected limb. Measurements of both spontaneous activity and responses of tarsal joint mechanoreceptors to repeated graded mechanical stimuli were made. All of the mechanoreceptors examined had afferent fibres with conduction velocities in the C or A- range. Using this new model of joint inflammation we have shown that lysine acetylsalicylate reduces the mechanical sensitivity of these joint mechanoreceptors and reduces the spontaneous activity in afferent nerve fibres. Prostaglandin E₂ is unable to restore either the spontaneous activity in the afferent axon or the mechanical sensitivity of tarsal joint mechanoreceptors after lysine acetylsalicylate in the arthritic rat. Similarly, PGE₂ does not sensitize or excite tarsal joint mechanoreceptors in the normal rat. In the normal rat, however, PGE₂ potentiates the excitatory action of bradykinin and enhances the sensitizing effect of bradykinin on the responses of joint mechanoreceptors to mechanical stimulation when both substances are injected simultaneously. These results indicate that PGE₂ is not important in the sensitization of these joint mechanoreceptors in this model of chronic joint inflammation but that in other circumstances PGE₂ may be able to contribute to a sensitization of joint mechanoreceptors by enhancing the action of bradykinin.     

Observation on therapeutic effect of cold moxibustion on rheumatoid interphalangeal arthritis

目的:观察冷灸对类风湿性指间关节炎的临床疗效.方法:将576例类风湿性指间关节炎随机分为冷灸组290例和对照组286例,治疗时间为2个月.结果:两者总有效率差异不明显,但在第2个疗程末前者完全缓解率达77.2%,后者仅23.4%,两者差异有显著意义(P＜0.005).结论:冷灸治疗类风湿性指间关节炎效果优于西药抗炎剂.     

Clinical analysis of knee osteoarthritis treated mainly by acupuncture

目的:了解不同治疗方法对膝关节骨关节炎的临床治疗效果.方法:对148例患膝随机分为4组进行针灸、中药频谱照射法、综合法、西药内服治疗,观察其疗效.结果:4组总有效率分别为78.9%,72.7%,92.3%和78.9%,各组之间无差异(P＞0.05).综合组显效率优于其他各组(P＜0.05).结论:针灸、中药频谱照射对膝骨关节炎有一定疗效,综合法能协同两者作用,使疗效提高.     

Clinical observation on scapulohumeral periarthritis treated by Tuina and SSP meridian therapeutic apparatus

目的:观察推拿结合经脉治疗仪治疗肩周炎的疗效.方法:观察组采用推拿结合日本产SSP经脉治疗仪治疗肩周炎患者35例.对照组单纯用经脉治疗仪治疗肩周炎患者30例.结果:观察组与对照组对肩周炎的治疗都有一定效果.但观察组的治愈率与对照组相比有明显差距(P＜0.01),观察组对肩周炎的治愈率明显高于对照组.结论:经脉治疗仪结合推拿是治疗肩周炎的一种有效方法.     

Clinical observation on treatment of 60 cases of osteoarthritis of knee joint by electroacupuncture

Purpose To observe therapeutic effect of electroacupuncture Neixiyan (Ex-LE 4) and Dubi (ST 35) in treating osteoarthritis of knee joint.Method All the 120 cases were randomly divided into electroacupuncture and control groups, 60 cases in each group, and they were given electroacupuncture and Ritalin slowreleased tablet respectively, and pain, mobility and swelling degree of knee joint were observed before and after treatments.Results In treatment group, the average score increased by 18, while in control group, it increased by 12.33 (P<0.05) after treatment.Conclusion Therapeutic effect of electroacupuncture Neixiyan (Ex-LE 4) and Dubi (ST 35) in treating osteoarthritis of knee joint was better than that of administration of Ritalin slow-released tablet. Author: DAI Qi-ping (1966-), female, attending physician Translator: Wu Xue-fei     

冷灸治疗类风湿性指间关节炎疗效观察

目的:观察冷灸对类风湿性指间关节炎的临床疗效。方法:将576例类风湿性指间关节炎随机分为治疗组(冷灸组)290例和对照组(服药组)286例,治疗时间为2个月。结果:两者总有效率虽然差异不明显,但在第二疗程末前者完全缓解率达77.2％,后者仅23.4％,经统计学处理P<0.005,两者差异有非常显著性意义。结论:冷灸治疗类风湿性指间关节炎效果优于西药抗炎剂。     

Adaptative effects of loss of vision on upright undisturbed stance

In order to evaluate the long term effect of blindness on an undisturbed postural task, seven blind individuals (BLI) were compared to twelve healthy individuals (REF) who were required to close their eyes. To this aim, centre of pressure (CP) trajectories were recorded through a force platform on which the subjects remained upright. Through a low-pass filter, the vertical projection of the centre of gravity (CG(v)) and consequently the difference CP-CG(v) were estimated. The former represents the controlled variable whilst the latter is assumed to express the resultant joint stiffness. A first analysis consisted in studying the frequency distribution of these motions. Increased mean amplitudes in both elementary motions and no difference between frequency distributions were observed for the BLI when compared to the REF group. These trajectories were then modelled as a fractional Brownian motion process in order to gain insight about the nature of the control mechanisms called into play and their spatio-temporal organisation. Moreover, the main characteristic observed in the BLI group is a decreased in CP-CG(v) motions, which, according to Winter's model, may be related to joint stiffness. In addition, reduced spatial transition point co-ordinates and more deterministic control mechanisms aimed at returning the estimated CG to an equilibrium point during the longest Deltat were observed. This phenomenon is more pronounced in the antero-posterior direction and also allows the blind subject to significantly diminish their CG sways. Finally, these features are discussed in relation to other similarly analysed investigations.     

三资企业从业人员心理卫生状况调查

[目的 ]　了解三资企业从业人员心理卫生现状。　 [方法 ]　采用症状自评量表 (SCL— 90 )对 776名三资企业从业人员心理卫生情况进行调查及分析。　 [结果 ]　三资企业从业人员SCL— 90量表得分均值高于全国常模 (P<0 .0 1) ;5年工龄以下 ,操作工人的躯体化、强迫症状、敌对、偏执、精神病性症状得分均值高于行政管理人员 (P <0 .0 5或P <0 .0 1) ;除强迫症状、精神病性症状外 ,有毒有害接触人员得分均值高于不接触有毒有害作业人员 (P <0 .0 5或P<0 .0 1) ;除敌对、精神病性症状外 ,女性得分均值高于男性 (P <0 .0 5或P <0 .0 1)。 5年以上工龄 ,除精神病性症状外 ,操作工人得分均值高于行政人员 (P <0 .0 5或P <0 .0 1) ;接触有毒有害人员以及女性得分均值分别高于不接触有毒有害人员和男性 (P <0 .0 5或P <0 .0 1)。　 [结论 ]　三资企业从业人员存在一定心理问题 ,有必要开展职业心理卫生的健康干预。     

儿童血友病429例临床回顾分析

目的探讨血友病患儿确诊时间、症状及其关节畸形等情况。 方法天津血液学研究所血液病医院于1986年7月至2004年8月，对就诊的429例血友病患儿临床症状出现时间、诊断时间及关节畸形出现的时间进行分析。 结果429例血友病患儿，均为男性，血友病A共390例，占909%，其中亚临床型5例(13%),轻型43例(110%)，中型181例(464%)，重型161例(413%)；血友病B共39例，占91%，其中亚临床型2例(51%),轻型6例(154%)，中型26例(667%)，重型5例(128%)。患儿初次出现出血症状的中位年龄为16岁(0~12岁)；但初次诊断年龄03~120岁，中位年龄为52岁(03~120岁)，两者之间差异具有显著性意义(P<001)。 结论目前血友病患儿的诊断存在延迟，替代治疗疗程和因子剂量的不足是关节畸形高发生率的原因。     

缝合锚钉在踝关节骨折合并三角韧带完全断裂修复中的应用

[目的]探讨缝合锚钉在踝关节骨折合并三角韧带完全断裂修复中的临床应用价值.[方法]回顾性分析本院2015年1月至2020年1月收治的69例踝关节骨折合并三角韧带完全断裂患者的临床资料.按患者手术中是否应用缝合锚钉修复三角韧带深层,将其分为修复组(36例)和未修复组(33例).对比两组术后1个月、术后6个月内侧间隙(MC...