Differential Prediction of Alcohol Use and Problems: The Role of Biopsychological and Social‐Environmental Variables

This study examined the differential prediction of alcohol use and problems by biopsychological (i.e., affective and cognitive variables) and social‐environmental (i.e., social norms) variables. Undergraduate students (N = 231) were assessed twice separated by a 30–day interval. Time 1 impulsivity, affect lability, social norms, and perceived conflict between personal strivings and alcohol use were each significant predictors of alcohol use–related problems at Time 2 (T2). Structural equation models indicated that impulsivity and affect lability were related directly with use‐related problems, while social norms and use‐strivings conflict were related indirectly with use‐related problems (mediated by use frequency). Impulsivity moderated the T2 use to use‐related problems relationship. Use frequency was associated more strongly with use‐related problems among more impulsive participants.     

COMT genotype,gambling activity,and cognition

Neuropsychological studies of adults with problem gambling indicate impairments across multiple cognitive domains. Catechol-O-methyltransferase (COMT) plays a unique role in the regulation of dopamine in the prefrontal cortex, and has been implicated in the cognitive dysfunction evident in problem gambling. This study examined adults with varying levels of gambling behavior to determine whether COMT genotype was associated with differences in gambling symptoms and cognitive functioning. 260 non-treatment-seeking adults aged 18–29 years with varying degrees of gambling behavior provided saliva samples for genotyping COMT val158met (rs4680). All subjects underwent clinical evaluations and neurocognitive assessment of decision-making, working memory, and impulsivity. The Val/Val COMT genotype was associated with the largest percentage of subjects with gambling disorder (31.8%), a rate significantly different from the Val/Met (13.2%) group (p = 0.001). The Val/Val COMT group was also associated with significantly more gambling disorder diagnostic criteria being met, greater frequency of gambling behavior, and significantly worse cognitive performance on the Cambridge Gamble Task (risk adjustment and delay aversion) and the Spatial Working Memory task (total errors). This study adds to the growing literature on the role of COMT in impulsive behaviors by showing that the Val/Val genotype was associated with specific clinical and cognitive elements among young adults who gamble, in the absence of differences on demographic measures and other cognitive domains. Future work should consider using genotyping to explore whether certain polymorphisms predict subsequent development of impulsive behaviors including gambling disorder, and treatment outcomes.     

Genetic contributions to social impulsivity and aggressiveness in vervet monkeys.

BACKGROUND: Impulsivity contributes to multiple psychiatric disorders and sociobehavioral problems, and the more serious consequences of impulsivity are typically manifest in social situations. This study assessed the genetic contribution to impulsivity and aggressiveness in a social context using a nonhuman primate model. METHODS: Subjects were 352 adolescent and adult vervet monkeys from an extended multigenerational pedigree. Behavior was assessed in the Intruder Challenge Test, a standardized test that measures impulsivity and aggressiveness toward a stranger. Genetic and maternal contributions to variation in the Social Impulsivity Index and its two subscales, impulsive approach and aggression, were estimated using variance components analyses. RESULTS: The results found significant genetic contributions to social impulsivity (h2 =.35 +/-.11) and to each of the subscales, with no significant influence of maternal environment. There was a high genetic correlation between the impulsive approach and aggression subscales (rho =.78 +/-.12). CONCLUSIONS: This is the first study to demonstrate heritability of social impulsivity in adolescents and adults for any nonhuman primate species. The high genetic correlation suggests the same genes may influence variation in both impulsive approach and aggression. These results provide a promising basis for identification of susceptibility loci for impulsivity and aggressiveness.     

ADHD儿童的心理特征及冲动行为的影响因素

目的:探索8～12岁注意缺陷多动障碍儿童的心理特征及冲动行为的影响因素。方法:70名ADHD儿童及126名健康儿童及其父母分别完成Barratt冲动行为量表、儿童焦虑性情绪障碍筛查表、儿童抑郁障碍自评量表、儿童社会期望量表、儿童青少年时间管理倾向量表和威斯康星卡片分类测验的评估。结果:①ADHD儿童比对照组有更多的冲动行为、焦虑、抑郁情绪;有较低的社会期望、时间管理能力(P0.05～0.01);②ADHD儿童的冲动行为与焦虑情绪、抑郁情绪呈正相关(P0.05～0.01);与社会期望、时间管理能力、WCST的非持续性错误数呈负相关(P0.05～0.01);③社会期望、WCST的非持续性错误数和时间管理倾向总分对冲动行为有预测作用,可以解释冲动行为变异的47%。结论:ADHD儿童存在认知、情绪和行为缺陷,冲动行为与其认知、情绪和行为特点有关。     

Sexual risk taking among young adult dual alcohol and marijuana users

Use of alcohol and marijuana among college students is common and use of these substances may increase the likelihood of risky sexual behavior. The present study found significant associations between risky sexual behavior and both mean BAC per drinking day and marijuana use intensity. However, hypothesized interactions between marijuana use and BAC were not supported. In addition, positive and negative urgency and premeditation were each significantly associated with the likelihood of risky sex. Substance use and facets of impulsivity and self-control exhibited direct associations with risky sexual behavior but hypothesized moderation effects were not supported. Associations between urgency and risky sexual behavior varied as a function of gender and trait positive affect.     

Neural correlates of impulsive responding in borderline personality disorder: ERP evidence for reduced action monitoring

Patients with borderline personality disorder (BPD) are characterized by marked impulsive behaviour. The impulsive response style of patients with BPD may be associated with diminished action monitoring, which can be investigated by measuring the error-related negativity (ERN). The ERN is an ERP component generated in the anterior cingulate cortex (ACC) following erroneous responses. Behavioural and ERP measurements were obtained during performance on a speeded two-choice reaction task in a group of patients with BPD (N=12) and in a group of age-matched controls (N=12). The ERP results showed that ERN amplitudes were reduced for patients with BPD, as were the P300 amplitudes after late feedback. The behavioural results confirmed a more impulsive response style for the BPD group, reflected in larger RT differences between correct and incorrect responses and in an increase in erroneous responses to the easy congruent stimuli. Additionally, analyses on post-error congruency effects demonstrated that controls adjusted their behaviour following errors, but patients with BPD did not. The attenuated ERNs indicate reduced action monitoring in patients with BPD. This suggests that the ACC, or the action-monitoring network it is part of, is not functioning optimally. Due to this reduced action monitoring, patients with BPD do not learn from their errors as well as controls. Consequently, they do not adjust their behaviour when necessary and thus maintain their impulsive response style.     

Les conduites suicidaires dans le trouble bipolaire de type 1

ObjectivesBipolar disorder is one of the most common and severe psychiatric conditions. It is frequently complicated by suicidal behaviors, and patients with BD are among those at higher risk of suicide. The aims of our study were to evaluate the predictive factors of suicidal behaviors in patients with BD type 1, through the assessment of their socio-demographic, clinical and evolutionary characteristics as well as to study the implications of the childhood traumas and impulsivity as predictive factors for suicidal behaviors in these patients with bipolar disorder.MethodsOne hundred patients with bipolar disorder type 1were recruited in order to conduct a cross-sectional, analytical and comparative study. The recruitment involved a first group made up of 40 patients suffering from type 1 bipolar disorder with a history of suicidal acts. This group was compared with a second group made up of 60 patients with no history of attempted suicide. We used a pre-established collection sheet for collecting socio-demographic, clinical and therapeutic data. We also used the Childhood Trauma Questionnaire for the assessment of childhood adversities, the Barratt Impulsivity Scale in its eleventh version for the assessment of impulsivity levels and the Global Assessment of Functioning Scale for the evaluation of overall functioning.ResultsThe suicidal behaviors in patients with bipolar disorder were significantly associated with: female gender (P < 0.001), professional instability (P = 0.002), family history of BD (P = 0.02), family history of other psychiatric disorders (P = 0.003), frequency of depressive episodes (P = 0.002), shorter remission (P = 0.025), more subsyndromal symptoms (P = 0.029), sexual abuse dimension (P = 0.009), and a high level of impulsivity (P < 0.001). The predictive factors for suicidal behaviors in multivariate analysis, after adjusting for the confounding variables were: childhood sexual abuse (P = 0.01; adjusted OR 4.5; 95% CI 1.44–14.2), a high level of impulsivity (P = 0.002; adjusted OR 6.6; 95% CI 2–20), a higher rate of depressive episodes (P = 0.003; adjusted OR 5; 95% CI 1.69–14.2) and more subyndromal symptoms (P = 0.007; adjusted OR 5.8; 95% CI 1.63–20).ConclusionsSuicide prevention is an important mental health subject. It would be imperative to include systematic screening for childhood adversities and adequate management of bipolar disorder and impulsivity.