Interindividual factors in respiratory behavior and longevity in OF1 mice

Respiratory activities of OF₁ SPF male and female mice, in a LD_12:12 (L = 100 lux) lighting regimen and in controlled environmental conditions (temperature: 20–21°C; humidity: 60–70%), were compared, sexes apart, either separated or grouped by 10–11 individuals, by measuring their VCO₂ (continuous recording and measurement of CO₂ concentration with an accuracy of 20 ppm). In both sexes grouping increases D→L and L→D respiratory variations. VCO₂ per mouse has a higher level in separated than in grouped individuals of both sexes, a higher level in grouped males than in grouped females, and shows only a small sex-related difference in separated mice. Longevity of separated males and separated females does not differ statistically. Longevity is decreased by grouping in males but increased by grouping in females.     

有色玻璃对人体血清钙、磷及碱性磷酸酶含量的影响

目的：进一步探讨有色玻璃对人体健康的影响，方法：选择蓝色、茶色、平板玻璃的房间进行室内紫外线辐射强度、照度、温度的监测，同时对相应人群血清中钙、磷、碱性磷酸酶进行检测。结果：有色玻璃环境的人群血清钙，磷含量低于平板玻璃环境的人群，碱性磷酸酶含量高于平板玻璃环境的人群，且差异均有显著性（P＜0．05），通过回归方程可以看出，血清中钙，磷含量均与玻璃的颜色成反比，结论：在北方寒冷地区，长期生活或工作在有色玻璃的房间内，会对体内血清钙，磷、碱性磷酸酶的正常含量产生影响，进而可能对人体健康产生一定的损害。     

国内外医疗器械软件安全性评价方法比较研究

采用比较研究与调研分析相结合的方法,通过对比欧美国家对医疗器械软件上市前评价与上市方法,并实地调研分析上海市医疗器械生产企业对软件研发质量控制程序,分析医疗器械软件安全存在的问题,并对高风险医疗器械软件的上市前安全性评价进行了有益的探索。     

Circadian activity rhythms of the pig-tailed macaque,Macaca nemestrina,under constant illumination

Lcomotor activity was recorded in singly caged pig-tailed macaques Macaca nemestrina in constant conditions with intensities of illumination varying between 0.003 lux and 100 lux. Each animal was kept in at least 5 different conditions for 2–3 weeks each. Three quantities of the circadian rhythm: the period, the duration of activity as opposed to rest, and the amount of activity per period, could be shown to be positively correlated with light intensity. As in 6 other diurnal primate species, these findings contradict the so-called circadian rule according to which opposite correlations should exist between the circadian parameters and light intensity in diurnal and in nocturnal species of animals.     

光照时长对老年性骨质疏松疗效的临床观察

目的探讨接受光照的时长对老年人骨质疏松的影响。方法按试验设计选取120例骨质疏松患者,分为实验1组、实验2组和对照组。3组患者禁烟酒,合理膳食(摄入富含钙、磷、蛋白质的膳食、水果),对照组每日(阴雨天除外)接受晨起8点到9点日照1 h,配合阿伦膦酸盐70 mg口服,每周1次,连续8个月。试验1组和试验2组在对照组基础上分别每日接受晨起光照2 h和3 h,连续8个月。观察内容主要是骨密度值的变化情况及疼痛的缓解程度。结果实验1组与对照组差异有显著性意义(P0.05),实验2组与实验1组差异无显著性意义(P0.05)。结论 2 h光照对骨质疏松症的治疗效果优于1h光照,且效果最为明显,光照3 h及以上对骨质疏松治疗效果与2 h无明显差异。     

Computer-based detection of bleeding and ulcer in wireless capsule endoscopy images by chromaticity moments

The wireless capsule endoscopy (WCE) invented by Given Imaging has been gradually used in hospitals due to its great breakthrough that it can view the entire small bowel for gastrointestinal diseases. However, a tough problem associated with this new technology is that too many images to be examined by eyes cause a huge burden to physicians, so it is significant if we can help physicians do diagnosis using computerized methods. In this paper, a new method aimed for bleeding and ulcer detection in WCE images is proposed. This new approach mainly focuses on color feature, also a very powerful clue used by physicians for diagnosis, to judge the status of gastrointestinal tract. We propose a new idea of chromaticity moment as the features to discriminate normal regions and abnormal regions, which make full use of the Tchebichef polynomials and the illumination invariant of HSI color space, and we verify performances of the proposed features by employing neural network classifier. Experimental results on our present image data of bleeding and ulcer show that it is feasible to exploit the proposed chromaticity moments to detect bleeding and ulcer for WCE images.     

Expression of GAP-43 in the retina of rats following protracted illumination

Distribution of GAP-43 was studied in the retinas of rats after continuous illumination followed by different darkness periods. GAP-43 immunoreactivity was maximum in regenerating outer photoreceptor segments of rats kept in total darkness for 10 days, while in the inner plexiform layer, immunoreactivity was maximum immediately after illumination. Changes in GAP-43 expression could participate in retinal repair/regeneration after light-induced damage.