高温高湿环境下颅脑火器伤亚低温治疗的实验研究

目的 观察早期亚低温治疗高温高湿环境下犬颅脑火器伤的疗效。方法 选杂种犬60只，制作出高温高湿环境下（气温39°C±0．5℃．相对湿度80％-85％）颅脑火器伤的动物模型，随机分为亚低温组和对照组，每组30只犬。亚低温组在术中采用静脉内输入1．2℃±0．34℃冷冻生理盐水．输液量为体重的5％，术后采用降温毯降温，体温控制在33～35℃，持续48h。对照组按常规治疗。Powlab／8SP生理记录仪动态监测生命体征变化和记录两组动物的生存率，分析比较二组的治疗结果。结果 亚低温组动物生命体征平稳，死亡率40％（12／30）；对照组动物生命体征紊乱，死亡率70％（21／30），两组死亡率差异显著（P〈0．05）。结论 早期亚低温治疗高温高湿环境下颅脑火器伤可以降低动物的死亡率。     

等距和非等距前交叉韧带重建的对比实验

目的 观察等距和非等距前交叉韧带(anterior cruciate ligament，ACL)重建对膝关节功能的影响。方法 采用新鲜尸体观察等距ACL的解剖结构，在尸体和模型上重建等距和非等距ACL，分别观察重建后ACL长度和胫骨平台表面压强的变化。结果 等距ACL的重建在膝关节的全范围活动中长度的变化值最小，胫骨平台所受的压强也最小。结论 只有等距的ACI。的重建才能恢复膝关节的正常生理功能，而非等距重建的ACL会造成膝关节的不稳定(或活动受限)，或者使膝关节表面的压强增加。     

Laser photobioactivation mechanisms: in vitro studies using ascorbic acid uptake and hydroxyproline formation as biochemical markers of irradiation response

Clinical investigations of laser photobioactivation, or biostimulation, might be differently designed and more fruitful if knowledge of basic biochemical mechanisms were better understood. In this investigation, biochemical events identified as responses to 904 nm irradiation included increased ascorbic acid uptake by fibroblasts. These cells also showed increased hydroxyproline formation, and this was increased several-fold by the addition of proline to the medium. Maximum biochemical responses were observed at a pulse frequency of 67 Hz and a pulse width of 150 nsec with an energy density of approximately 7 mJ/cm2 per exposure. Elements in the mitochondrial cytochrome system are proposed as the radiation absorbing chromophore(s). Hypothetically, the energy generated is linked to ascorbic acid uptake, which in turn stimulates collagen synthesis.     

Effects of Hostility on Alcohol Stress-Response-Dampening

The purpose of this study was to compare the stress-response-dampening (SRD) effect of alcohol in hostile and nonhostile men based on a combined score of four subscales of the Cook-Medley Hostility Scale . Subjects were 72 male social drinkers. Subjects' cardiac interbeat-interval, and systolic and diastolic blood pressure reactivity to a situational stressor were measured following the consumption of either alcohol, no alcohol, or an active placebo beverage. Results demonstrated that hostile men evinced lower heart rate and systolic blood pressure (SBP) reactivity to the stressor when given alcohol, compared with intoxicated nonhostile subjects, and lower reactivity relative to all other groups, with the exception of SBP in the nonhostile controls. These results allow for speculation that hostile men may be more likely than controls to experience possible SRD effects of alcohol and thus, perhaps, be predisposed to increased alcohol consumption when under stress.     

农药唑呀威毒理及中毒治疗的实验研究

唑呀威（Ｔｒｉａｚｕｒｏｎ）系新型的高效杀蚜虫剂。目前，对其抑制胆碱酯酶活性的毒理尚报道不一。作者在进行毒性测试和发现１６名包装工夏季作业时８名出现明显症状的基础上，开展动物实验研究。结果发现，唑呀威有较有机磷农药更为快速的胆碱酯酶抑制作用，大鼠经口染毒１１２．５ｍｇ／ｋｇ仅３０ｍｉｎ内即见全血胆碱酯酶活性显著下降，Ｐ＜０．０１；且存在明显剂量－反应关系。高剂量（２００ｍｇ／ｋｇ）还可引起心血管系统的损害。注射阿托品有显著解救效果，染毒同时给药的解救效果明显优于染毒后５分钟给药，提示愈早给药解救效果愈好。作者由此提出了临床中毒急救措施的建议     

Prolidase Activity in Chronic Wound and Blister Fluids

We investigated prolidase activity in samples derived from wound fluid as well as blister fluid. Prolidase activity was elevated in fluid samples collected from wounds over the levels in sera collected from patients with chronic wounds (P<0.05). Prolidase activity was also present in samples taken from blister diseases. However, prolidase activity in blister fluid was not higher than that in sera collected from patients with blister diseases. Our results indicate that prolidase may play a role in wound healing.     

温阳健心灵口服液治疗充血性心力衰竭的临床与实验研究

以煎剂形成筛选治疗CHF的处方，发现温阳益气方改善泵血功能的效果优于单纯益气和养阴益气的处方。根据前方制备的温阳健心灵口服液保持了原煎剂的疗效，并被毒理学试验证明毒性极低。动物药效学及临床试验发现该药不仅能改善心衰犬和病人的左室收缩功能，还能改善其舒张功能。除此，它还具有利尿作用和使PAWA、SVR和PVR下降的作用，这也是它抗心衰的机理之一。90例的临床观察（疗程2周）表明该药总有效率、近期治愈率和显效率分别达88．9％、7．4％和18．5％，其效与开搏通组无明显差异。     

Chemotherapy in intracerebrally transplanted tumors induced with transplacental administration of ethylnitrosourea in rats

Summary Four tumors of the spinal cord were induced with ethylnitrosourea in rats by transplacental administration and transplanted into the brains of animals of the same strain. One of these intracerebrally grafted tumor lines (G-XIII) was followed up over the first 10 passages and treated with CCNU and other alkylating drugs. The results were compared with findings in an earlier established line (G-XII) in passage 12 and 59, which in the first instance was sensitive to CCNU. The CCNU application prolonged survival in treated animals in various treatment schedules in the first 10 intracerebrally grafted generations of the tumor up to 59%. Induction times of tumors became increasingly shorter. The susceptibility of early passages was similar in both lines. Its loss in late passages went together with diffuse growth of the tumor and reticulin fiber production. In addition, glial fibrillary acid protein expression and formation of intermediate filaments in perivascular tumor cells was lost.     

ATP和SNP控制性降压对血流动力学的影响

对比研究三磷酸腺苷（ＡＴＰ）和硝普钠（ＳＮＰ）控制性降压对氯胺酮麻醉犬血流动力学的影响。选择犬１４只，随机分为ＡＴＰ组和ＳＮＰ组，由股静脉持续输入ＡＴＰ和ＳＮＰ使ＭＡＰ降低３０％￣４０％，维持３０ｍｉｎ，分别于降压前、降压后１５ｍｉｎ、３０ｍｉｎ及停止降压后１５ｍｉｎ用Ｓｗａｎ－Ｇａｎｚ漂浮导管测定血流动力学指标。结果表明，ＡＴＰ、ＳＮＰ降压期间ＳＶＲ、ＬＶＳＷ显著降低，ＣＯ、ＰＣＷＰ、ＳＶ、ＲＶ