全文获取类型
收费全文 | 725篇 |
免费 | 105篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 43篇 |
儿科学 | 48篇 |
妇产科学 | 5篇 |
基础医学 | 167篇 |
口腔科学 | 19篇 |
临床医学 | 25篇 |
内科学 | 126篇 |
皮肤病学 | 20篇 |
神经病学 | 16篇 |
特种医学 | 8篇 |
外科学 | 73篇 |
综合类 | 48篇 |
预防医学 | 18篇 |
眼科学 | 8篇 |
药学 | 21篇 |
中国医学 | 1篇 |
肿瘤学 | 196篇 |
出版年
2023年 | 17篇 |
2022年 | 14篇 |
2021年 | 23篇 |
2020年 | 44篇 |
2019年 | 44篇 |
2018年 | 43篇 |
2017年 | 45篇 |
2016年 | 21篇 |
2015年 | 27篇 |
2014年 | 37篇 |
2013年 | 60篇 |
2012年 | 23篇 |
2011年 | 26篇 |
2010年 | 21篇 |
2009年 | 13篇 |
2008年 | 18篇 |
2007年 | 20篇 |
2006年 | 28篇 |
2005年 | 20篇 |
2004年 | 31篇 |
2003年 | 36篇 |
2002年 | 43篇 |
2001年 | 42篇 |
2000年 | 23篇 |
1999年 | 14篇 |
1998年 | 12篇 |
1997年 | 14篇 |
1996年 | 8篇 |
1995年 | 2篇 |
1994年 | 7篇 |
1992年 | 1篇 |
1991年 | 2篇 |
1990年 | 1篇 |
1989年 | 3篇 |
1988年 | 2篇 |
1986年 | 1篇 |
1985年 | 6篇 |
1984年 | 7篇 |
1983年 | 7篇 |
1982年 | 6篇 |
1981年 | 6篇 |
1980年 | 3篇 |
1979年 | 4篇 |
1978年 | 4篇 |
1977年 | 2篇 |
1976年 | 1篇 |
1975年 | 3篇 |
1974年 | 1篇 |
1973年 | 4篇 |
1971年 | 2篇 |
排序方式: 共有842条查询结果,搜索用时 15 毫秒
51.
52.
Thoufeeq MH Ali Khan SL Jain SK Al-Shakerchi H Hussain M 《World journal of gastroenterology : WJG》2007,13(4):637-638
Hepatitis is an important but uncommon manifestation of acute Epstein Barr infection. Infectious mononucleosis is usually a disease of young adults. We report a case of infectious mononucleosis in a 72-year old jaundiced gentleman with ferritin level of 2438 that normalised on clinical improvement. 相似文献
53.
Thompson MA Habra MA Routbort MJ Holsinger FC Perrier ND Waguespack SG Rodriguez MA 《American journal of hematology》2007,82(4):299-303
We report the first case of a primary adrenal natural killer (NK)/T-cell nasal type lymphoma in adults. The patient presented with an enlarging left adrenal mass and the initial concern was for adrenocortical carcinoma. Surgical resection revealed NK/T-cell lymphoma. Rapid recurrence in the contralateral adrenal gland was treated with a single cycle of chemotherapy before he died due to infectious complications and progressive disease. This case demonstrates the aggressive presentation of a novel subset of primary adrenal lymphoma that should be considered in the differential diagnosis of a rapidly enlarging adrenal mass. 相似文献
54.
55.
56.
57.
Renné C Hinsch N Willenbrock K Fuchs M Klapper W Engert A Küppers R Hansmann ML Bräuninger A 《International journal of cancer. Journal international du cancer》2007,120(11):2504-2509
The Hodgkin-Reed/Sternberg (HRS) cells of classical Hodgkin's lymphoma (HL) aberrantly express up to 7 different receptor tyrosine kinases (RTK) with extensive heterogeneity regarding the number and combinations of expressed RTKs in individual cases and a more prominent coexpression in nodular-sclerosis (ns) than mixed-cellularity (mc) HL. To investigate whether RTK expression patterns are related to other pathogenetic mechanisms and clinical behaviour, we analysed a large collection of EBV(+) and EBV(-) cases of ns and mc subtype and cases with relapses for expression of the 7 RTKs. No specific relation of any RTK to a specific group of cases was observed. The analysis of average numbers of expressed RTKs per case as a measure for strength of overall RTK signalling revealed a relation with the histological subtype and the EBV-status. RTK coexpression was significantly higher in EBV(-) nsHL cases compared to both EBV(-) and EBV(+) mcHL cases. Among mcHL cases RTK coexpression was significantly higher in EBV(-) compared to EBV(+) cases. Coexpression of 3 and more RTKs was largely restricted to EBV(-) cases. The inverse correlation between strong RTK signalling and presence of EBV may indicate that RTK signalling can at least partially replace the role of EBV in HRS cell pathogenesis. For cases with aberrant coexpression of several RTKs inclusion of RTK inhibitors in therapy regimens may be a novel option. 相似文献
58.
de Sanjosé S Bosch R Schouten T Verkuijlen S Nieters A Foretova L Maynadié M Cocco PL Staines A Becker N Brennan P Benavente Y Boffetta P Meijer CJ Middeldorp JM 《International journal of cancer. Journal international du cancer》2007,121(8):1806-1812
Epstein-Barr Virus (EBV) is consistently associated with distinct lymphoproliferative malignancies and aberrant EBV antibody patterns are found in most EBV cancer patients. We evaluate the detection of an abnormal reactive serological pattern to EBV (ab_EBV) infection and the risk of lymphoma in a multicentric case-control study. Serum samples were collected at study entry from 1,085 incident lymphoma cases from Spain, France, Germany, Czech Republic, Italy and 1,153 age, sex and country matched controls. EBV immunoglobulin G (IgG) serostatus was evaluated through a peptide-based ELISA combining immunodominant epitopes of EBNA1 (BKRF1) and VCA-p18 (BFRF3). Further, immunoblot analysis was performed to evaluate distinct antibody diversity patterns to EBV early antigens (EA), besides EBNA1, VCA-p18, VCA-p40 (BdRF1) and Zebra (BZLF1). Patients with chronic active EBV infection and aberrant EBV activity were characterized as having an abnormal reactive pattern (ab_EBV). Ab_EBV was observed in 20.9% of 2,238 included subjects with an increased proportion of cases presenting ab_EBV as compared to the control population (23.9% vs. 18.0% p = 0.001). Ab_EBV positivity was a risk factor for all lymphomas combined (odds ratio [OR] = 1.42, 95% confidence interval [CI]=1.15-1.74), and specifically for chronic lymphocytic leukaemia (OR = 2.96, 95%CI = 2.22-3.95). Lower levels of ab_EBV were observed for follicular lymphoma (OR = 0.38, 95%CI = 0.15-0.98). EBV may be involved in a larger subset of lymphomas among clinically immunocompetent subjects than previously thought, probably explained by an underlying loss of immune control of EBV latent infection. Ab_EBV is a useful tool to explore EBV imbalances preceding or paralleling possible EBV associated oncogenic events. 相似文献
59.
bcl-2、P 5 3基因及Epstein-Barr病毒在鼻咽癌中的表达 总被引:1,自引:0,他引:1
目的探讨鼻咽癌组织中p53、bcl-2、EBV表达情况及与主要临床指标间关系.方法免疫组化检测p53、bcl-2蛋白,多聚酶链反应(PCR)检测EBV.结果慢性炎性组织中p53、bcl-2及EBV阳性率分别为7.7%、23.1%和7.7%,明显低于鼻咽癌组织中的阳性率(分别为75.9%、88.9%和87.0%)(P<0.01).三者在鼻咽癌组织中共同阳性率为72.2%,p53、bcl-2明显正相关(r=0.78,P<0.01).鼻咽癌伴颈淋巴结转移组p53阳性率(90.0%)明显高于无颈淋巴结转移组(58.3%)(P<0.01),临床Ⅱ、Ⅲ和Ⅳ期p53阳性率(分别为92.9%、78.9%和100%)均明显高于临床I期(38.5%)(P<0.01),且表达强度有增加的趋势.结论p53、bcl-2及EBV可作为鼻咽癌早期诊断的辅助指标之一,p53阳性的鼻咽癌患者较易发生颈淋巴结转移,随着鼻咽癌病程的发展,p53表达率及表达强度均增加,三者在鼻咽癌发生发展中起着重要作用. 相似文献
60.
X-linked lymphoproliferative disease (XLP) is a rare immunodeficiency disease characterized by severe immune disorder and extreme vulnerability to Epstein-Barr virus (EBV) infections. Here we report a 14-month-old Chinese boy presenting with fulminant infectious mononucleosis (FIM) following EBV infection, and died of hepatic failure within one week of disease progression. Postmortem examination revealed icterus, ascites, extensive enlarged mesenteric lymph nodes and hepatosplenomegaly. Histopathological examination showed diffuse proliferation of cytotoxic T lymphoid cells and hemophagocytosis in multiple organs. The family history revealed his brother had died under similar circumstances at 5 five years of age. The cause of death of the boy was ascribed to XLP. To the best of our knowledge, there is few autopsy-confirmed XLP case in the forensic practice. The complicated manifestations and systemic pathological changes should be well recognized by clinicians and forensic pathologists. 相似文献