全文获取类型
收费全文 | 95410篇 |
免费 | 9161篇 |
国内免费 | 2192篇 |
专业分类
耳鼻咽喉 | 719篇 |
儿科学 | 1284篇 |
妇产科学 | 633篇 |
基础医学 | 6341篇 |
口腔科学 | 1533篇 |
临床医学 | 17716篇 |
内科学 | 10921篇 |
皮肤病学 | 503篇 |
神经病学 | 12760篇 |
特种医学 | 26596篇 |
外国民族医学 | 20篇 |
外科学 | 6777篇 |
综合类 | 9551篇 |
现状与发展 | 2篇 |
一般理论 | 1篇 |
预防医学 | 1984篇 |
眼科学 | 1352篇 |
药学 | 3524篇 |
62篇 | |
中国医学 | 658篇 |
肿瘤学 | 3826篇 |
出版年
2024年 | 339篇 |
2023年 | 1698篇 |
2022年 | 3464篇 |
2021年 | 4400篇 |
2020年 | 4014篇 |
2019年 | 3722篇 |
2018年 | 3615篇 |
2017年 | 3850篇 |
2016年 | 4042篇 |
2015年 | 3989篇 |
2014年 | 6807篇 |
2013年 | 6057篇 |
2012年 | 5628篇 |
2011年 | 6090篇 |
2010年 | 5138篇 |
2009年 | 5300篇 |
2008年 | 5216篇 |
2007年 | 4906篇 |
2006年 | 4391篇 |
2005年 | 3851篇 |
2004年 | 3228篇 |
2003年 | 2578篇 |
2002年 | 2062篇 |
2001年 | 1925篇 |
2000年 | 1573篇 |
1999年 | 1256篇 |
1998年 | 1228篇 |
1997年 | 1142篇 |
1996年 | 1003篇 |
1995年 | 862篇 |
1994年 | 733篇 |
1993年 | 589篇 |
1992年 | 448篇 |
1991年 | 335篇 |
1990年 | 260篇 |
1989年 | 191篇 |
1988年 | 167篇 |
1987年 | 145篇 |
1986年 | 114篇 |
1985年 | 89篇 |
1984年 | 73篇 |
1983年 | 51篇 |
1982年 | 45篇 |
1981年 | 33篇 |
1980年 | 34篇 |
1979年 | 21篇 |
1978年 | 15篇 |
1977年 | 9篇 |
1976年 | 11篇 |
1971年 | 7篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
51.
雄激素不敏感综合征(androgen insensitivity syndrome,AIS)又称为睾丸女性化综合征(testicular feminization syndrome,TFS),是一种X连锁遗传病,是男性假两性畸形中较常见的类型,可分为完全型AIS和不完全型AIS,其原因主要是雄激素受体(androgen receptor,AR)基因的突变导致其对雄激素产生抵抗和不应答。本文回顾南京医科大学附属妇产医院2例CAIS患者的临床资料及诊疗过程,以期能进一步提高对该病的认知及诊治水平。 相似文献
52.
Soosai Manickam Amirtham Ozlem Ozbey Upasana Kachroo Boopalan Ramasamy Elizabeth Vinod 《Clinical anatomy (New York, N.Y.)》2020,33(3):343-349
Bone containing tissues such as osteochondral joint are resistant to routine tissue processing, therefore require decalcification. This technique causes removal of mineral salts, but in the process may macerate the organic tissue, hence the need for tissue fixation. Such severe processing demands careful antigen retrieval to necessitate optimal staining. The aim of our study was to compare five different antigen retrieval protocols (heat retrieval and protein digestion) following decalcification of rabbit knee joints using two different techniques (20% formic acid and 10% ethylenediamine-tetra acetic acid: EDTA). Osteochondral sections were compared based on time required for decalcification, ease of sectioning, morphological integrity using HE staining and antigen preservation (Collagen type II) using immunohistochemistry. The two decalcification solutions did not impair the tissue morphology and ease of sectioning. Joints processed with formic acid decalcified four times faster than EDTA. Among the five antigen retrieval approaches, maximal collagen II uptake with minimal nonspecific staining was found with protein digestion (pronase and hyaluronidase) in both formic acid and EDTA sections. For osteo-chondral sections, we recommend using 10% EDTA for decalcification and pronase plus hyaluronidase for antigen retrieval if maintaining tissue morphology is crucial, whereas if time is of the essence, 20% FA with pronase plus hyaluronidase is the faster option while still preserving structural integrity. Clin. Anat. 33:343–349, 2020. © 2019 Wiley Periodicals, Inc. 相似文献
53.
54.
55.
56.
57.
58.
Subacute sclerosing panencephalitis (SSPE) is a rare, slowly progressing but invariably fatal disease that is related to a prior measles virus infection and most commonly affects paediatric patients. Magnetic resonance (MR) imaging is the modality of choice for determining such changes in white matter. SSPE typically demonstrates bilateral but asymmetric periventricular and subcortical white matter involvement. We herein report a rare case of unilateral white matter involvement in a 13-year-old boy with SSPE that closely simulated Rasmussen’s encephalitis. To the best of our knowledge, this is the first report of an atypical presentation on MR imaging in which SSPE was a rare cause of unilateral brain parenchymal involvement in a patient with intractable seizures. 相似文献
59.
MEMRI and tumors: a method for the evaluation of the contribution of Mn(II) ions in the extracellular compartment
下载免费PDF全文
![点击此处可从《NMR in biomedicine》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Eliana Gianolio Francesca Arena Enza Di Gregorio Roberto Pagliarin Martina Delbianco Gabriella Baio Silvio Aime 《NMR in biomedicine》2015,28(9):1104-1110
The purpose of the work was to set‐up a simple method to evaluate the contribution of Mn2+ ions in the intra‐ and extracellular tumor compartments in a MEMRI experiment. This task has been tackled by “silencing” the relaxation enhancement arising from Mn2+ ions in the extracellular space. In vitro relaxometric measurements allowed assessment of the sequestering activity of DO2A (1,4,7,10‐tetraazacyclododecane‐1,7‐diacetic acid) towards Mn2+ ions, as the addition of Ca‐DO2A to a solution of MnCl2 causes a drop of relaxivity upon the formation of the highly stable and low‐relaxivity Mn‐DO2A. It has been proved that the sequestering ability of DO2A towards Mn2+ ions is also fully effective in the presence of serum albumin. Moreover, it has been shown that Mn‐DO2A does not enter cell membranes, nor does the presence of Ca‐DO2A in the extracellular space prompt migration of Mn ions from the intracellular compartment. On this basis the in vivo, instantaneous, drop in SE% (percent signal enhancement) in T1‐weighted images is taken as evidence of the sequestration of extracellular Mn2+ ions upon addition of Ca‐DO2A. By applying the method to B16F10 tumor bearing mice, T1 decrease is readily detected in the tumor region, whereas a negligible change in SE% is observed in kidneys, liver and muscle. The relaxometric MRI results have been validated by ICP‐MS measurements. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
60.
《Biomaterials》2015
Mesoporous silica nanoparticles (MSNs) can provide a structural foundation for a new generation of nanocarriers with a broad range of functionalities. Multifunctional MSNs can serve as all-in-one diagnostic and therapeutic tools that can be used to simultaneously visualize and treat various diseases, such as cancer. This research study is the first time that two lanthanide-based imaging systems have been combined to incorporate controlled drug release and targeted tracing into a single MSN-based nano-platform for a novel theranostic drug delivery system. Doping lanthanide ions, i.e., europium (Eu) and gadolinium (Gd) ions, into an MSN structure (EuGd-MSNs) imparts fluorescence and magnetism to the nanostructure that can be used to develop magnetic resonance imaging (MRI) and biological fluorescence tools. Current cancer research has revealed that most human cancer cells express a large number of folate receptors on their surface. Grafting folic acid (FA) onto the EuGd-MSN surface (EuGd-FA-MSNs) imparts a targeting function to the MSN because of the specificity of the binding of FA to cell surface receptors. Furthermore, grafting anticancer drugs, such as camptothecin (CPT), onto the surface of these MSNs by forming disulfide bonds (EuGd-SS-CPT-FA-MSNs) enables intracellular controlled drug release. A high concentration of intracellular glutathione cleaves the disulfide bond to release the drug and treat the disease. The results of in vitro and in vivo studies show that the functionalized MSNs can be successfully used as a platform to integrate dual-imaging, targeting, and therapeutic treatment in multifunctional diagnosis drug delivery systems. 相似文献