Distinguishment of A 42 Capsomere Structure of Icosohedral Virion from A 32 One by Electron Microsco

ＤｉｓｔｉｎｇｕｉｓｈｍｅｎｔｏｆＡ４２ＣａｐｓｏｍｅｒｅＳｔｒｕｃｔｕｒｅｏｆＩｃｏｓｏｈｅｄｒａｌＶｉｒｉｏｎｆｒｏｍＡ３２ＯｎｅｂｙＥｌｅｃｔｒｏｎＭｉｃｒｏｓｃｏｐｅＣｎｅｎＢｉｎｇｙｉｎｇ（陈丙莺）；ＺｈｏｕＴｏｎｇ（周）（Ｄｅｐａｒｔｍｅ...     

三种调味品对小鼠内脏器官的影响

目的探讨过量八角、花椒及桂皮对小鼠内脏器官的影响。方法分别使用不同浓度三种调味品的提取液灌胃 ,采用病理学检验技术 ,观察小鼠肝脏、肾脏等器官的病理学变化 ,并计算出肝、肾、脾的脏体系数。结果调味品各组小鼠的肝脏、肾脏和脾脏重量都有所增加 ,脏体系数有不同程度升高 ,与正常组比较 ,差异具显著性 (P <0 .0 5 ,P <0 .0 1 )。肝脏、肾脏可见明显形态学改变 ,肝脏的损伤主要表现在肝细胞胞浆疏松化和气球样变 ,甚至出现双核、巨核和分裂相。肾脏损伤主要表现为肾小管上皮细胞水肿 ,肾小球毛细血管充血、出血。脾脏未见明显改变。结论三种调味品过量使用时 ,对小鼠肝脏、肾脏和脾脏有不同程度的损伤 ,但病变的程度与调味品的剂量关系不大 ,而与其种类关系较密切。八角的毒性反应最为明显 ,桂皮次之 ,花椒的影响较小     

氧化损伤与铅毒性研究进展

铅是一种对全身组织有广泛亲和力的毒物,作用的基点是体内一些生物大分子(蛋白质、脂类、核酸),进而使大分子受损,影响到细胞功能.     

A stereotactic approach to deep-seated central nervous system neoplasms using the carbon dioxide laser

This report describes a technique in which deep-seated CNS neoplasms, the volume and shape of which had been determined and stereotactically localized by computer reconstruction of CT data, were vaporized with a carbon dioxide laser attached to a stereotactic frame. The clinical results with 6 patients treated by this technique are presented.     

Transplantation of central nervous tissue

Studies of post-lesional reorganization of central nervous connections have shown that central nerve fibers respond to nearby denervation by sprouting and formation of new terminals. The connections in the central nervous system (CNS) are accordingly much more plastic than was thought for a long time. This has revived the interest in transplantation of central nervous tissue. In this study we present some historical data on CNS transplantation supplemented by recent results obtained in our laboratory. Pieces of hippocampal tissue from embryonic or early postnatal rats were transplanted to different parts of the brain of littermates or adult rats. About two-thirds of the transplants were recovered after survival times ranging from 4 d to 2 years, and their cytological organization and intrinsic connections were monitored by cell and fiber stains and histochemical methods (AChE staining and Timm sulphide silver method). Comparison with both a normal and a lesioned control material revealed that in most transplants the tissue had developed as it does when left in situ in the donor brain, but deprived of its major afferent connections. In several instances we found evidence of a major exchange of connections between the transplants and host brains. The conditions needed for this to occur appeared to involve growth stimulation of host brain fibers by transection (host to transplant) and denervation of host neuropil (transplant to host). In cases where these conditions are met, the use of transplants may have future implications in attempts to repair lesions in the central nervous systems.     

酥胆麒麟膏用于痔瘘术后换药的药效学与毒理学研究（二）

本文通过设一个阳性对照组（马应龙鹰香痔疮膏），一个空白对照组（凡士林）及酥胆麒麟膏大、中、小三个剂量组（１０％、２０％、４０％浓度）进行三个方面的实验研究，证实酥胆麒麟膏具有止血、抗菌、生肌长皮等综合作用，局部外用无毒副作用，安全性高。其止血、生肌长皮作用，优于马应龙麝香痔疮膏；抗金葡萄茵的作用与银灰散相同；抗大肠杆菌的作用犹于银灰散。尤其是２０％酥胆麒麟膏的以上多种作用优于１０％浓度的，等效于４０％浓度的，可作为临床使用时的最佳浓度。     

镉对大鼠肾脏和睾丸毒性的比较

大鼠饮水中给镉12wk后,检测了尿低分子蛋白(LMWP)排出量。尿碱性磷酸酶(ALP)活性,血清睾酮水平,睾丸乳酸脱氢酶同功酶(LDH-X)活性,精子计数和形态,雄鼠生育力,肾,睾丸和附睾组织镉含量,并在光镜和电镜下观察上述组织的病理变化,从生化,形态和功能改变三方面比较了大鼠肾脏和睾丸对镉的敏感性,发现尿LMWP和ALP仅在高剂量组显著增加,而血清睾酮和睾丸LDH-X在中剂量纽和低剂量纽已明显降低,说明镉对睾丸的有害作用可出现在肾脏之前。     

邻甲苯胺的毒性研究

邻甲苯胺经口半数致死量为７５５ｍｇ／ｋｇ，属低毒类。动物染毒邻甲苯胺１９ｍｇ／ｋｇ以上引起小鼠脾脏增大，３８ｍｇ／ｋｇ以上引起白细胞计数升高，且淋巴细胞百分比升高，各染每剂量对小因清免疫球蛋白ＩｇＧ含量和巨噬细胞吞噬功能无明显影响。结果表明，邻甲苯胺对造血系统有影响，对免疫系统无明显直接影响。