氢氧化钙碘仿糊剂修复髓室底穿孔的临床研究

目的 观察氢氧化钙碘仿糊剂修复髓室底穿孔的临床疗效。方法 选择髓室底穿孔的患者65例，患牙68颗，随机分为两组，试验组采用氢氧化钙碘仿糊荆修复髓室底穿孔，再用玻璃离子水门汀垫底，对照组直接采用玻璃离子水门汀修复穿孔。一年后复查，观察其治疗效果。结果 试验组成功率(76．19％)明显高于对照组，两组间有显著性差异，并且其疗效与穿孔原因及穿孔直径有密切关系。结论 氢氧化钙碘仿糊剂是一种良好的髓室底穿孔的修复材料。     

Prognostic value of PINP, bone alkaline phosphatase, CTX-I, and YKL-40 in patients with metastatic prostate carcinoma

BACKGROUND: To examine the prognostic value of markers of bone metabolism (serum PINP, BAP, and CTX-I) and serum YKL-40 in metastatic prostate carcinoma (PC). METHODS: The biomarkers were determined by ELISAs in 153 metastatic PC patients before treatment with parenteral estrogen or total androgen ablation. The median follow-up was 4.9 years. One hundred fifteen patients died. RESULTS: The biomarkers were increased in the patients compared to controls (P < 0.001), and related to performance status and Soloway score (except YKL-40), but not to T-category and WHO tumor grade. PINP was elevated in 87%, BAP (55%), CTX-I (33%), and YKL-40 (43%). Univariate analysis showed an association to survival: PINP (HR = 1.6, P < 0.0001), BAP (HR = 1.4, P < 0.0001), CTX-I (HR = 1.7, P < 0.0001), and YKL-40 (HR = 1.4, P = 0.004). In multivariate Cox analysis performance status, WHO grade, Soloway score, PINP, and YKL-40 were independently predictive factors. CONCLUSIONS: High serum PINP, BAP, CTX-I, and YKL-40 are associated with poor outcome of metastatic PC patients.     

YKL-40在动脉粥样硬化中的作用

YKL-40（人软骨糖蛋白-39）是一种新发现的炎性因子,属于哺乳动物18-糖基水解酶家族成员。既往研究表明,YKL-40与急慢性炎症性疾病和肿瘤等有关。近年来的研究显示,YKL-40可能参与了动脉粥样硬化斑块的发生和发展,并且与斑块不稳定性相关。YKL-40的生物学功能和作用机制尚不完全清楚,可能具有促进血管平滑肌迁移和增殖、促进细胞黏附和增殖以及调控细胞外基质重构等作用。YKL-40的检测对于心脑血管病的辅助诊断、预后判断、预防乃至新的治疗策略建立等均有一定的意义。     

CHI3L1-329 G/A基因多态性与冠心病相关性的研究

目的:炎症在冠状动脉粥样硬化性心脏病(冠心病,CAD)中起着重要的作用?多项研究中关于几丁质酶3样蛋白1(chitinase 3-like protein 1,CHI3L1)-329 G/A基因多态性与冠心病的关系存在争议?本研究的目的在于观察江苏地区人群中CHI3L1-329 G/A多态性与冠心病的关系?方法:本研究入选391例患者,其中189例CAD,202例正常对照?通过连接酶检测反应(ligase detection reaction,LDR)检测CHI3L1单核苷酸多态性(single nucleotide polymorphism,SNP)位点的基因型及等位基因频率?结果:冠心病患者和正常对照组之间CHI3L1基因型频率分布差别无统计学意义?GA?AA基因型和等位基因G?A频率在心肌梗死组?不稳定性心绞痛组和稳定性心绞痛组中的分布差异有统计学意义(P < 0.05);但是在不同病变血管中分布无差异(P > 0.05)?结论:CHI3LI-329 G/A基因多态性与江苏地区人群的冠心病没有相关性?     

小婴儿沙眼衣原体肺炎26例临床分析

目的：探讨小婴儿肺炎的病原体，为临床治疗提供依据。方法：收集２１７ 例６ 个月以下肺炎患儿的鼻咽分泌物，用聚合酶链反应方法检测沙眼衣原体（ＣＴ） 。结果：２１７ 例患儿中，ＣＴ 阳性２６ 例，阳性率为１２－０ ％ 。临床表现以咳嗽、气促、肺部罗音为主，肺外表现以消化系统症状最为明显。结论：ＣＴ 为小婴儿肺炎常见的病原体。     

Observational and genetic plasma YKL‐40 and cancer in 96,099 individuals from the general population

Plasma YKL‐40 is high in patients with cancer and in individuals who later develop cancer. Whether YKL‐40 is only a marker or indeed a cause of cancer is presently unknown. We tested the hypothesis that observationally and genetically, high plasma YKL‐40 is associated with high risk of cancer. For this purpose, we performed cohort and Mendelian randomization studies in 96,099 individuals from the Danish general population. Plasma levels of YKL‐40 were measured in 21,643 and CHI3L1 rs4950928 was genotyped in 94,568 individuals. From 1943 through 2011, 2,291 individuals developed gastrointestinal cancer, 913 developed lung cancer, 2,863 women developed breast cancer, 1,557 men developed prostate cancer and 5,146 individuals developed other cancer. Follow‐up was 100% complete. Multifactorially and CRP adjusted hazard ratio (HR) for gastrointestinal cancer was 1.82 (95%CI, 1.16–2.86) for 96–100% versus 0–33% YKL‐40 percentile category. Corresponding HR were 1.71 (0.95–3.07) for lung cancer, but insignificant for breast cancer, prostate cancer and other cancers. CHI3L1 rs4950928 genotype was associated with plasmaYKL‐40 levels, but not with risk of any cancer category. For gastrointestinal cancer, a doubling in YKL‐40 was associated with a multifactorially and CRP adjusted observational HR of 1.14(1.05–1.23) for gastrointestinal cancer, but a corresponding genetic odds ratio of 1.06(0.94–1.18). For lung cancer, corresponding risk estimates were 1.11(1.00–1.22) observationally and 1.01(0.84–1.20) genetically. For other cancer categories, observational and genetic findings were insignificant. This study shows that high plasma YKL‐40 levels were associated with high risk of gastrointestinal and likely of lung cancer, but genetic high levels were not.     

支气管哮喘相关基因CHI3L1的研究进展

支气管哮喘(简称哮喘)是一种具有明显遗传倾向的变态反应性疾病,多年来对哮喘相关基因进行了大量研究,但尚未取得突破性进展.CHI3L1基因是一种新发现的哮喘相关基因,编码一种几丁质酶样蛋白YKL-40.本文对CHI3L1基因、YKL-40的分布、功能及其可能参与哮喘发病的机制作一综述.     

氢氧化钙碘仿糊剂修复髓室底穿孔的临床效果分析

目的：观察氢氧化钙碘仿糊剂修复髓室底穿孔的临床疗效。方法：选择髓室底穿孔的患者64例,患牙67颗,随机分为两组,实验组采用氢氧化钙碘仿糊剂修复髓室底穿孔,再用玻璃离子水门汀垫底,对照组直接用玻璃离子水门汀修复穿孔。一年后复查,观察其治疗效果。结果：试验组成功率(75．61％)明显高于对照组,两组间有显著性差异,并且其疗效与穿孔原因及穿孔直径有密切关系。结论：氢氧化钙碘仿糊剂是一种良好的髓室底穿孔的修复材料。     

清糜导赤汤治疗顽固性乳糜血尿

本文运用补阴益气煎合导赤散,加滋阴清热、凉血止血药,组成清糜导赤汤,治疗10年以上,反复发作的顽固性乳糜血尿6例。结果取得较为满意的疗效,全部患者症状消失,蛋白血尿消失,乳糜试验转阴,除一例还在观察外,其余病例随访3～5年,未见复发。因而认为:乳糜血尿脾肾气阴两虚为其本,湿热下注是其标,对顽固性乳糜血尿治宜补阴益气为主,佐以清热利湿。