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通过对86例原发性胆汁返流性胃炎空腹1h胃液三羟胆酸含量、游离酸测定,研究三羟胆酸与萎缩性胃炎(CAG)、胃癌癌前病变的关系。结果表明:CAG组三羟胆酸含量明显高于浅表性胃炎组(CSG)及对照组,尤以CAG伴结肠型肠化、不典型增生者含量最高,而游离酸值最低。胃粘膜活检见大量中性粒细胞浸润,以CAG组明显(55.2%)。提示胆汁酸浓度与胃粘膜炎症程度、性质密切相关,胆汁返流致胃酸过少继发细菌感染,是促使CAG、胃癌前病变发生的重要因素之一。胃游离酸检测与胃腺体受损程度不平行,但测定空腹胃游离酸对判断病情轻重及预后有临床实用价值。 相似文献
23.
H.-W. Zhang X. Zhao Y.-L. Guo Y. Gao C.-G. Zhu N.-Q. Wu J.-J. Li 《Nutrition, metabolism, and cardiovascular diseases : NMCD》2018,28(10):980-986
Background and aims
The role of lipoprotein (a) [Lp(a)] in coronary artery diseases (CAD) with special clinical background such as type 2 diabetes mellitus (T2DM) has not been fully determined. The aim of the present study was to investigate the relation of Lp(a) to type 2 diabetic patients with or without CAD.Methods and results
A total of 2040 consecutive patients with T2DM who received selective coronary angiography (CAG) due to angina-like chest pain were enrolled. The patients were subsequently divided into CAD and non-CAD groups according to the results of CAG. The severity of CAD was evaluated by the Gensini Score (GS), number of stenotic vessels, and history of myocardial infarction (MI). Data showed that Lp(a) levels were higher in the CAD group than in the non-CAD group (median: 15.00 mg/dL vs. 11.88 mg/dL, P = 0.025). The results from CAD subgroup analysis indicated that the patients with MI, multiple-vessel disease and high GS had higher Lp(a) levels compared with those in their matched subgroups (P < 0.05, respectively). After adjustment for confounders, Lp(a) levels were independently related to the presence and severity of CAD (CAD:OR = 1.564; MI:OR = 1.523; high GS:OR = 1.388; multiple-vessel disease:OR = 1.455; P < 0.05, respectively).Conclusion
Elevated Lp(a) levels were independently associated with the presence and severity of CAD in patients with T2DM. More studies are necessary to confirm our findings. 相似文献24.
25.
Baowei Zhang Wenhui Peng Hailing Li Yuyan Lu Jianhui Zhuang Ke Wang Yang Su Yawei Xu 《Clinical biochemistry》2013
Objective
Previous studies suggested that decreased serum vaspin levels were associated with coronary artery disease (CAD). The present study aimed to investigate the association between plasma vaspin levels and different states of CAD.Design and methods
A total of 162 patients with coronary angiography (CAG) proved that CAD was enrolled. Additional 103 patients complained with “chest discomfort” with negative CAG, and 60 normal subjects were enrolled in this study. The levels of plasma vaspin, adiponectin, clinical parameters, lipid profile and C reactive protein (CRP) were measured.Results
The levels of plasma vaspin were significantly lower in the CAD group (0.47 ± 0.63 μg/L) than those in the healthy group and CAG (−) group (all p < 0.001). In CAD group, the pos hoc analysis showed that serum vaspin concentration in acute myocardial infarction group (0.21 ± 0.19 μg/L) was significantly lower than that in the unstable angina pectoris group (0.40 ± 0.37 μg/L) (p = 0.012), and serum vaspin concentration in unstable angina pectoris was significantly lower than that in stable angina pectoris group (0.92 ± 0.94 μg/L) (p = 0.013). The plasma vaspin concentration was also negatively correlated with the severity of CAD (1-vessel: 0.86 ± 0.90 μg/L; 2-vessel: 0.36 ± 0.39 μg/L; 3-vessel: 0.21 ± 0.16 μg/L). The plasma vaspin concentration in CAG (−) group with “chest discomfort” (1.93 ± 2.57 μg/L) was similar to the healthy control group (2.18 ± 3.49 μg/L).Conclusions
The plasma vaspin concentration correlated to the severity of CAD. Furthermore, plasma vaspin has a value of avoiding patients without CAD from unnecessary CAG. 相似文献26.
目的:观察复方蜥蜴散对慢性萎缩性胃炎(Chronic atrophic gastritis,CAG)模型大鼠血清NO及iNOS水平的影响,探讨其治疗CAG的作用机制。方法:采取55℃热盐水、2%水杨酸、20mmol/L脱氧胆酸钠三个致萎缩因素配合饥饱失常造成CAG模型。将实验动物分为正常对照组,模型对照组,维酶素组,复方蜥蜴散高、中、低剂量组。检测大鼠血液中NO和iNOS水平及观察胃黏膜组织学方面的改变。结果:模型组大鼠NO和iNOS水平明显高于正常组(P<0.01),病理组织学上也有较大改变,而经复方蜥蜴散治疗1个月后,NO和iNOS水平恢复正常,胃黏膜病理组织学改善明显。结论:复方蜥蜴散可以逆转萎缩胃黏膜的病理改变,发挥保护胃黏膜的作用。 相似文献
27.
28.
Luis Velázquez Pérez Gilberto Sánchez CruzNieves Santos Falcón Luis Enrique Almaguer MederosKarel Escalona Batallan Roberto Rodríguez LabradaMilena Paneque Herrera José Miguel Laffita MesaJulio C. Rodríguez Díaz Raúl Aguilera RodríguezYanetza González Zaldivar Dany Coello AlmaralesDennis Almaguer Gotay Humberto Jorge Cedeño 《Neuroscience letters》2009
The objective of this study was to determine the prevalence of hereditary ataxias in Cuba, with a special focus on the clinical and molecular features of SCA2. Clinical assessments were performed by neurological examinations and application of the SARA scale. Molecular analyses of genes SCA1–3, SCA6, SCA17 and DRPLA identified 753 patients with SCA and 7173 asymptomatic relatives, belonging to 200 unrelated families. 86.79% of all SCA patients were affected with SCA2. In the Holguin province, the average population prevalence of SCA2 is 40.18 × 105 inhabitants, with the remarkable figure of 141.66 × 105 in the Baguanos municipality. The high prevalence of the SCA2 mutation in Holguin reflects most likely a founder effect. The stabilization of the prevalence along time suggests the existence of premutated chromosomes with pure CAG, acting as reservoir for further expansions. CAG repeat length correlated inversely with age at onset, accounting for 80% of the variability. Genetic anticipation was observed in the 80% of transmissions. Repeat instability was greater in paternal transmissions whereas CAG expansions without anticipation was observed in 10.97% suggesting the effect of CAA interruptions in the CAG segment, which decrease the toxicity of the abnormal ataxin-2, and/or other protective factors. 相似文献
29.
Analysis of SCA8 and SCA12 loci in 134 Italian ataxic patients negative for SCA1–3, 6 and 7 CAG expansions 总被引:1,自引:0,他引:1
Brusco A Cagnoli C Franco A Dragone E Nardacchione A Grosso E Mortara P Mutani R Migone N Orsi L 《Journal of neurology》2002,249(7):923-929
Spinocerebellar ataxias (SCA) are a heterogeneous group of neurodegenerative disorders, six of which are caused by expansion
of a polyglutamine-coding CAG repeats (SCA1- 3, 6, 7 and 17). In addition, expansions of a CAG triplet in the 5' region of a gene and a CTG triplet in an antisense RNA have been demonstrated
in the SCA12 and SCA8 genes respectively. Our series of 134 ataxic patients (22 familial and 112 sporadic, tested negative for SCAI–3, 6, 7) was investigated for the presence of triplet expansions in the SCA8 and SCA12 genes. No SCA12 expansion was identified. A moderate SCA8 expansion (85–97 repeats) was found in two unrelated families with slowly progressive cerebellar ataxia. The frequency of
SCA8 expansion accounts for ∼4.3 % of the whole pool of our ataxia families (2 out of 46), while none of the 127 controls screened
carried > 35 CTG+CTA repeats. Our data suggest a possible pathogenetic role of this mutation, which at present is still controversial,
and confirm the rarity of the SCA12 expansion in Italian patients.
Received: 30 March 2001, Received in revised form: 20 November 2001, Accepted: 15 January 2002 相似文献
30.
Spinocerebellar ataxia (SCA) type 7 is an autosomal dominant disorder characterized by neural loss, mainly in the cerebellum and regions of the brainstem and particularly the inferior olivary complex. This neurodegeneration disease is associated with expansion of unstable CAG repeats within the 5'-translated region of the SCA7 gene, located on chromosome 3p. We conducted a local survey of the normal population and candidate patients for the analysis of the CAG repeats in the SCA7 gene. The distributions of the CAG repeat units of SCA7 gene in the normal population in Taiwan were established in this study by using the radioactive genomic polymerase chain reaction (PCR). The normal range of CAG repeats is from 6 to 17 repeats, with the more common being around 8-13 repeats. The range is narrower than that reported for other ethnic groups (7-35 CAGs). Meanwhile, by the use of a combination of PCR and Southern blot analysis, one SCA7 family was identified and is reported here. A marked instability of the CAG repeat number during transmission from father to son (41 vs. 100) was observed in the SCA7 family. Clinical anticipation is significant in this family including an infantile case, who was found to have nystagmus from the age of 1 month. To date, the SCA7 mutation has been detected in one of 73 families with autosomal dominant cerebellar ataxia phenotypes, which is about 1.4% of the ataxia families referred to us, compared to 1.4% SCA1, 9.6% SCA2, and 27.3% SCA3/Machado-Joseph disease in our collection. In addition, we demonstrate that the PCR-based Southern blot analysis, with the advantages of sensitivity of PCR and specificity of Southern blot, is a reliable diagnostic method for SCA7 mutation screening. The molecular analysis technique makes possible the quick and accurate diagnosis of SCA7 patients and in the future will hopefully be applied to prenatal screening for SCA7 families. 相似文献