重点高中生的心理状态与高考成绩的相关性研究

目的;了解重点高中学生的心理状态与高考成绩之间的关系。方法：以398例应届生为对象,应用16PF人格测验,气质测量工具（STI,TTI）及焦虑自评量表（SAS）,对考生进行测试分析,结果：文理科学生的16PF的人格特质有明显的差别,判别分析和多因素回归分析显示16PF人格特质中的Q1因素（实验性F＝8．76,P＜0．01）,Q2因素（独立性F＝8．23,P＜0．01）,与高考成绩呈正相关,与M因素（幻想性F＝4．88,P＜0．01）,呈负相关;气质中的神经过程灵活性（F＝8．15,P＜0．01）和时间特质中的灵活性（F＝12．36,P＜0．01）与高才成绩呈正相关。结论：高考生的实验性,独立性高分及幻想性低分的个性特质和气质上的灵活性有助于高考成绩的发挥,学生文理科分班宜参考学生人格特质这一特点,。     

厦门市1993～2000年儿童死因动态及生存水平分析

目的　了解厦门市 5岁以下儿童死因变化及生存水平 ,提高儿童的生命质量及医疗保健服务水平。方法　通过市、区、街道 (乡 )妇幼保健三级网及儿童生命监测系统收集资料 ,对 1993～ 2 0 0 0年厦门市 5岁以下儿童死亡监测情况统计分析。结果　 5岁以下儿童死亡率呈逐年下降趋势 ,1993年为 2 7 88‰ ,2 0 0 0年为 11 6 6‰ ,(X2 =80 0 0 ,P <0 0 1)。厦门市 1993～ 2 0 0 0年 5岁以下儿童主要死因为肺炎、出生窒息、早产、先天畸形、腹泻 ,肺炎和腹泻呈下降趋势 ,早产、出生窒息、先天畸形呈上升趋势 ,其中先天畸形上升较明显。儿童死前均得到相应的医疗保健服务 ,死前就医、死前明确诊断、死于医疗保健机构者均达 90 %以上。结论　厦门市 5岁以下儿童死亡率逐年下降 ,已达到《九十年代中国儿童发展规划纲要》的要求。提高医疗保健机构的诊治水平和服务水平是社会的需求 ,也是提高儿童生存水平的措施之一 ,全社会都应重视这项工作。     

肝毒性中药及其与药性和有效成分的关系——对55种中药肝毒性文献资料的分析报告

目的 :研究有关文献资料中中药肝毒性的报告及其与四气、五味、归经、有效成分之间的关系。方法 :应用文献研究方法 ,对 55种具有肝毒性的中药进行统计归类分析研究。结果 :中药四气、五味、归经及其有效成分与肝毒性有一定相关性。肝毒性主要集中在寒、热类 ,苦、辛类 ,归肝、脾、肾经类和有效成分中碱、甙类药物方面。结论 :中药药性理论及有效成分均与肝毒性有一定的关系 ,应用归类分析的方法对文献资料进行分析研究是中药毒性研究中确实可行的方法。     

调畅五脏、调和营卫治疗自汗临证体会

通过分析汗与五脏、营卫的关系,探讨自汗证的病因病机,概括为五脏皆有汗,汗之本为心,汗之化为肾,汗之出为肺,汗之源为脾胃,汗之调为肝。又必以营卫调和为要,汗出方能有节。五脏功能失调、营卫失和均可致自汗。故提出“调畅五脏、调和营卫”的自汗证治则及处方用药,通过典型临床病案,进一步阐释诊疗思路及用药规律。     

基于人工智能感官与多源信息融合技术的五味药性二分类辨识方法探讨

目的 探究人工智能感官与多源信息融合技术用于中药五味药性二分类辨识方法的可行性,为中药药性评价提供新的方法借鉴。方法 选取122种仅含单一味不含兼味的5类代表性中药饮片（源自《中国药典》2020年版）及14种常用的食品类样本,使用PEN3型电子鼻及ASTREE、SA402B型电子舌采集136种样本的智能感官信息,以得到的信息矩阵作为自变量（X）,药典项下的性味描述等作为标杆信息（Y）,利用主成分分析-判别分析（principal component analysis-discriminant analysis,PCA-DA）、最小二乘-支持向量机（least squares-support vector machine,LS-SVM）2种化学计量学方法,分别基于单一型号智能感官设备（单源）和多智能感官信息融合（多源）建立五味二分类（酸/非酸、咸/非咸、辛/非辛、甘/非甘、苦/非苦）辨识模型Y=F(X),以交互验证的正判率作为模型优选指标。结果 经留一法交互验证,基于单源信息的五味二分类模型中最大正判率分别是98.53%(ASTREE/PCA-DA、LS-SVM)、97.06%(ASTR...     

大五人格因素与企业职工工作倦怠的关系

目的:探讨大五人格因素与企业职工工作倦怠的关系。方法:采用工作倦怠问卷(MBI-GS)与大五人格问卷调查了506名某企业职工。结果:分层回归分析的结果显示,在控制了人口统计学变量之后,大五人格因素所解释的工作倦怠的方差变异量,在情绪衰竭、玩世不恭和职业效能三个维度分别为28%、24%和17%。具体而言,宜人性是情绪衰竭、玩世不恭和职业效能的有效预测因子;责任感是玩世不恭和职业效能的有效预测因子;情绪稳定性是情绪衰竭和玩世不恭的有效预测因子;而外向性和开放性两个维度对工作倦怠的预测作用均未达到显著水平。结论:大五人格因素能够有效预测企业职工的工作倦怠。     

Endogenous estrogen status, but not genistein supplementation, modulates 7,12-dimethylbenz[a]anthracene-induced mutation in the liver cII gene of transgenic big blue rats

A growing number of studies suggest that isoflavones found in soybeans have estrogenic activity and may safely alleviate the symptoms of menopause. One of these isoflavones, genistein, is commonly used by postmenopausal women as an alternative to hormone replacement therapy. Although sex hormones have been implicated as an important risk factor for the development of hepatocellular carcinoma, there are limited data on the potential effects of the estrogens, including phytoestrogens, on chemical mutagenesis in liver. Because of the association between mutation induction and the carcinogenesis process, we investigated whether endogenous estrogen and supplemental genistein affect 7,12-dimethylbenz[a]anthracene (DMBA)-induced mutagenesis in rat liver. Intact and ovariectomized female Big Blue rats were treated with 80 mg DMBA/kg body weight. Some of the rats also received a supplement of 1,000 ppm genistein. Sixteen weeks after the carcinogen treatment, the rats were sacrificed, their livers were removed, and mutant frequencies (MFs) and types of mutations were determined in the liver cII gene. DMBA significantly increased the MFs in liver for both the intact and ovariectomized rats. While there was no significant difference in MF between the ovariectomized and intact control animals, the mutation induction by DMBA in the ovariectomized groups was significantly higher than that in the intact groups. Dietary genistein did not alter these responses. Molecular analysis of the mutants showed that DMBA induced chemical-specific types of mutations in the liver cII gene. These results suggest that endogenous ovarian hormones have an inhibitory effect on liver mutagenesis by DMBA, whereas dietary genistein does not modulate spontaneous or DMBA-induced mutagenesis in either intact or ovariectomized rats.     

人格特征、自尊水平与航空兵部队人员心理健康的关系

目的:探讨航空兵部队人员人格特征、自尊水平与心理健康的关系。方法:运用EPQ、SES、SCL-90对443名航空兵部队人员进行调查。结果:神经质与SCL-90总均分成正相关(r=0.641,P<0.01);内外向与SCL-90总均分成负相关(r=-0.232,P<0.01);精神质与SCL-90总均分成正相关(r=0.398,P<0.01);自尊水平与SCL-90总均分成负相关(r=-0.381,P<0.01);神经质、精神质、自尊水平进入回归方程(P<0.001);神经质、精神质对心理健康有直接影响(效应系数分别为0.513和0.209);内外向、神经质通过影响自尊水平对心理健康具有间接效应(效应系数分别为0.216和-0.261)。结论:神经质、精神质和内外向是影响心理健康的因素,具有直接作用和间接作用两个方面;自尊是人格影响心理健康的中间环节。     

父母养育方式与中学生个性特点及心理健康的相关分析

目的 探讨父母养育方式对中学生个性及心理健康的影响。方法 采用父母养育方式评价量表（EMBU）,艾森克个性问卷（EPQ）,心理卫生自评量表（SCL－90）,对140名高中一年级学生进行测查。结果：1．父母养育方式与中学生个性特点具有相关性。2．学生的个性特点与自身的心理健康水平密切相关。3．女生的个性与心理健康问题多于男性。结论 父母养育方式与中学生个性的形成和心理健康有密切关系。     

The effect of big endothelin-1 in the proximal tubule of the rat kidney

1. An obligatory step in the biosynthesis of endothelin-1 (ET-1) is the conversion of its inactive precursor, big ET-1, into the mature form by the action of specific, phosphoramidon-sensitive, endothelin converting enzyme(s) (ECE). Disparate effects of big ET-1 and ET-1 on renal tubule function suggest that big ET-1 might directly influence renal tubule function. Therefore, the role of the enzymatic conversion of big ET-1 into ET-1 in eliciting the functional response (generation of 1,2-diacylglycerol) to big ET-1 was studied in the rat proximal tubules.
2. In renal cortical slices incubated with big ET-1, pretreatment with phosphoramidon (an ECE inhibitor) reduced tissue immunoreactive ET-1 to a level similar to that of cortical tissue not exposed to big ET-1. This confirms the presence and effectiveness of ECE inhibition by phosphoramidon.
3. In freshly isolated proximal tubule cells, big ET-1 stimulated the generation of 1,2-diacylglycerol (DAG) in a time- and dose-dependent manner. Neither phosphoramidon nor chymostatin, a chymase inhibitor, influenced the generation of DAG evoked by big ET-1.
4. Big ET-1-dependent synthesis of DAG was found in the brush-border membrane. It was unaffected by BQ123, an ET_A receptor antagonist, but was blocked by bosentan, an ET_A,B-nonselective endothelin receptor antagonist.
5. These results suggest that the proximal tubule is a site for the direct effect of big ET-1 in the rat kidney. The effect of big ET-1 is confined to the brush-border membrane of the proximal tubule, which may be the site of big ET-1-sensitive receptors.