精神分裂症攻击行为与血清胆固醇水平

目的：探讨血清胆固醇水平与精神分裂症患者冲动攻击行为的关系。方法：以既往史和外显攻击行为量表(MOAS)评分区分，有攻击行为者为冲动行为组，无攻击行为者(无冲动组)及健康者(正常对照组)为对照，比较3组的血清胆固醇水平，并与简明精神病评定量表(BPRS)、MOAS进行相关分析。结果：冲动行为组较无冲动组及正常对照组胆固醇水平显著低。结论：精神分裂症患者的攻击行为可能与胆固醇水平有关。     

Aggressive angiomyxoma of the vulva

BACKGROUND: Aggressive angiomyxoma is a rare soft tissue tumour that carries a high risk of local relapse. It is a slowly growing and locally infiltrating tumour. CASE: We describe the case of an aggressive pelvic-perineal angiomyxoma arising in a 36-year-old woman. The patient had a mass that grew before, during and after her pregnancy. Transperineal surgery was performed. The resection margins were free of disease. CONCLUSION: Our case confirms what has previously been published concerning the possible hormone-dependence of this neoplasm. Given the positive estrogen and progesterone receptor status of this tumour, we will consider hormonal treatments in the case of a future relapse.     

Drinking, personality, and bar environmental characteristics as predictors of involvement in barroom aggression

Theoretical approaches to alcohol and violence have emphasized three interrelated domains of influence: the situational context, aggression-facilitating characteristics of individuals, and the impact of alcohol consumption. We examined these three domains as predictors of experiencing violence in the barroom setting. Participants were recruited through one of two phone surveys or through newspaper advertisements and classified into one of three groups: Experienced Bar Violence (EBV), Observed Bar Violence (OBV), and No Bar Violence (NBV). They completed questionnaires assessing individual difference and alcohol use variables, and an interview that assessed characteristics of their usual bar. The results suggested that individual difference and alcohol variables distinguished men in the EBV group from men in the OBV and NBV groups. However, women in the EBV group were distinguished from women in the NBV group by the characteristics of their usual bar and by the alcohol variables, but were distinguished from the OBV group only in terms of individual difference variables. The implications of these findings with respect to the influence of alcohol on barroom violence are discussed.     

Psychometric properties of the Chinese Behavior Problems Inventory-01 in children and adolescents with or at risk for intellectual disabilities

As the world's most populous country, China is likely to have the highest number of people with intellectual disabilities (ID) in the world. As many people with ID are susceptible to serious and persistent behavior problems, research by Chinese scientists on this public health issue is needed. However, there are only very few reliable Chinese-language behavior assessment instruments for problem behaviors. To fill this gap we translated the Behavior Problems Inventory-01 (BPI-01; Rojahn, Matson, Lott, Esbensen, & Smalls, 2001) into Chinese. The BPI-01 is an informant-based behavior rating instrument that was designed to assess self-injurious behavior (SIB), stereotyped behavior, and aggressive/destructive behavior in individuals with ID. We then assessed the behavior of 222 children and young adults (age range 1.5–21.5 years) with or at risk for ID from three special needs service programs in mainland China. Teachers or staff members, respectively, served as respondents. The Chinese version of the BPI-01 showed good reliability (internal consistency) and good factor validity tested by confirmatory factorial analysis. We conclude that the Chinese version of the BPI-01 can be used for research and clinical evaluation of Chinese children and adolescents with ID.     

侵袭性牙周炎患者疱疹病毒感染和外周血病毒载量

目的分析不同严重程度侵袭性牙周炎(AGP)患者疱疹病毒(HV)感染情况和外周血病毒载量。方法选取2014年12月-2019年12月济南市市中区人民医院口腔科收治的2600例AGP患者,根据病变程度分为轻度AGP组(n=82)、中度AGP组(n=578)、重度AGP组(n=1940),以同期100名健康人群为对照组。入组后,检测龈沟液HV病毒感染情况和血浆单纯疱疹病毒1型(HSV-1)、EB病毒(EBV)、人类巨细胞病毒(HCMV)、人类疱疹病毒6型(HHV-6)载量、牙周特征和血炎症因子水平。结果AGP患者牙周菌斑指数(PLI)、探诊深度(PD)、附着丧失(AL)、出血指数(BI)高于对照组(P<0.05),HSV-1、EBV、HCMV、HHV-6感染率和病毒载量高于对照组(P<0.05),白细胞(WBC)、降钙素原(PCT)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C-反应蛋白(CRP)高于对照组(P<0.05);随着AGP病情严重程度增加,HSV-1、EBV、HCMV、HHV-6感染率和病毒载量、PLI、PD、AL、BI、WBC、PCT、IL-6、TNF-α和CRP均增加(P<0.05)。结论HV感染率和病毒载量与AGP患者血清炎症因子水平和牙周特征随病情严重程度增加而升高。     

Behavioral effects of flumazenil in the social conflict test in mice

Rationale Flumazenil, a competitive antagonist of benzodiazepine receptors (BZRs), has been used as a probe to detect effects of putative endogenous ligands for BZRs in anxiety. Flumazenil is renowned for its highly inconsistent behavioral effects.Objective To ascertain effects of flumazenil in the social conflict test in mice, which provides complex measures for prediction of anxiolytic and anxiogenic activity of drugs in behaviorally different groups of animals.Methods Singly housed male mice treated with flumazenil (5, 20 or 80 mg/kg i.p.) or vehicle were paired with untreated non-aggressive group-housed male mice in a novel cage. Behavior was analyzed from video tapes of the social interactions in three populations of mice: timid (n=21), aggressive (n=11), and sociable (n=7). Levels of -aminobutyric acid (GABA) were measured in vivo in the prefrontal cortex.Results Flumazenil reduced timid (defensive-escape) and increased locomotor activities in timid mice. The drug reduced aggressive and increased sociable (social investigation) activities in aggressive mice. These behavioral changes were produced at the lowest dose of flumazenil tested (5 mg/kg) and were not increased further by higher doses of the drug (20 mg/kg or 80 mg/kg). A tendency to increased timidity was found after flumazenil in sociable mice. Concentrations of GABA were markedly higher in the prefrontal cortex of sociable mice than in timid or aggressive mice.Conclusions Flumazenil produced moderate anxiolytic-like behavioural changes and a slight anxiogenic-like effect. The present data might be reflecting antagonism of corresponding endogenous BZR ligands. However, these putative ligands seem to exert only modest modulatory influence.     

神经节苷脂注射液7例聚集性不良反应分析

摘 要 目的:分析神经节苷脂钠注射液出现聚集性不良反应的影响因素。方法：调阅本院ADR/ADE 监测系统内的7份神经节苷脂注射液聚集性不良反应记录及相关病历,对用药人群、使用环节、ADR症状等因素进行调查分析。结果：经质量检验,此次使用的神经节苷脂注射液为合格药品,此次聚集性不良反应表现为抽搐、寒战、发热等过敏样症状。7例聚集性不良反应的发生时间、溶媒选择、药物用量、滴速等因素基本相同,仅在溶媒用量、合并用药方面存在差异。结论：导致聚集性不良反应发生的影响因素很多,难以确定某个具体因素。聚集性ADR一旦发现,应立即停药,及时上报,寻找原因,推动药品质量不断提高和临床用药不断规范。     

基于logistic回归分析的康复方案对住院精神分裂症患者攻击行为的预防作用

目的　分析住院精神分裂症患者攻击行为的影响因素,探究针对性康复干预对患者攻击行为的预防效果。方法　选择2019年1月至2020年8月山东省精神卫生中心接收248例住院精神分裂症患者,其中男135例,女113例,年龄23～67（38.03±0.41）岁。根据修改版外显攻击行为量表（MOAS）总加权分划分为攻击组（MOAS≥4分）、非攻击组（MOAS<4分）。比较两组患者的一般临床资料、阴性及阳性症状量表的兴奋因子（PANSS-EC）与中文版模棱两可、目的和敌意问卷（AIHQ-C）、社会支持评定量表（SSRS）、疾病不确定感（MUIS-A）情况。多因素logistic分析患者攻击行为的独立影响因素,并制定针对性康复方案。采用随机数字表法将山东省精神卫生中心2020年9月至2021年9月接收的100例精神分裂症患者［男57例,女43例,年龄20～69（38.38±2.51）岁］划分为两组。对照组实施常规干预,研究组在对照组基础上联合实施针对性康复方案。入院两个月,比较两组干预前后的攻击行为情况以及PANSS-EC、AIHQ-C、SSRS、MUIS-A评分。研究数据应用SPSS 26.0软件处理,计量资料给予t检验,计数资料给予χ²检验,等级资料给予秩和检验。结果　多因素logistic分析显示,男性、入院前1个月有攻击行为史、非自愿住院、首次住院、PANSS-EC评分、AIHQ-C敌意偏向总分、AIHQ-C责备偏向总分、AIHQ-C攻击偏向总分、SSRS客观支持得分、SSRS主观支持得分、MUIS-A不明确性得分、MUIS-A复杂性得分是住院精神分裂症患者攻击行为的独立影响因素（均P<0.05）;患者入院两个月,实施针对性康复方案后,研究组攻击行为发生率（16.00%,8/50）低于对照组（36.00%,18/50）,MOAS评分为（2.01±0.32）分,低于对照组的（3.56±0.24）分,两组比较,差异均有统计学意义（χ²=5.198,t=27.400,均P<0.05）;干预后,研究组PANSS-EC评分为（9.20±0.32）分、AIHQ-C评分为（13.48±1.11）分、SSRS评分为（33.21±2.47）分、MUIS-A评分为（70.31±3.56）分,均优于对照组［（11.21±0.28）分、（17.46±1.29）分、（30.29±3.03）分、（85.35±3.20）分］,两组比较,差异均有统计学意义（t=33.426、16.537、5.282、22.217,均P<0.05）。结论　精神分裂症患者攻击行为受多方面因素共同影响,针对性康复方案干预可有效改善患者攻击行为诱因,降低攻击行为发生率。     

60例住院精神病患者攻击行为原因分析及对策

目的分析住院精神病患者发生攻击行为的原因,探讨有效的护理措施,有效降低攻击行为带来的伤害。方法对我院精神科的60例住院精神病患者攻击行为发生的临床资料进行分析,分析其原因,并采取有效护理措施。结果精神病患者发生攻击行为的主要原因有:被害妄想20例,占33.33%,命令性幻听18例,占30%,情绪不稳10例,16.67%,思维紊乱6例,占10%,要求得不到满足4例,占6.67%,药源性反应2例,占3.33%。结论被精神症状所支配,是造成精神病患者攻击行为产生的主要因素,及时识别发生攻击行为的先兆和及时控制冲动的行为的发生,采取合理的护理措施,能够有效预防并降低攻击行为带来的伤害。