《弟子规》阅读对男性精神分裂症患者攻击行为的影响

目的 探讨<弟子规>阅读对男性精神分裂症患者攻击行为的影响.方法 以60例男性精神分裂症患者为研究对象,按床号单双号分为观察组和对照组各30例,对照组患者采用常规抗精神病药物治疗及精神科常规护理、康复管理措施,观察组在此基础上增加<弟子规>阅读,比较两组患者攻击行为的发生数和修改版外显攻击行为量表、忍耐性(宽容性)量表评分情况.结果 观察组攻击行为发生数少于对照组,修改版外显攻击行为量表评分低于对照组,忍耐性(宽容性)量表评分高于对照组.结论 <弟子规>阅读可以减少男性精神分裂症患者的攻击行为.     

Aggressive fibromatosis of the leg and sacrococcygeal region: a report of two cases

Aggressive fibromatosis is a rare soft tissue tumor that composes of myofibroblasts that arise from musculoaponeurotic structures. It usually affects the abdominal wall but may be also found in other less common sites including the head and neck, submucosa of the oral cavity, spinal, haunch and limbs, especially, the limbs and sacrococcygeal region are rare locations. We described two cases of aggressive fibromatosis. One was 3-year-old girl with aggressive fibromatosis arising from the right leg region. The other was 20-year-old female arising from in the sacrococcygeal region. They were resected with satisfied results. Pathological examination showed that they were composed of fibroblasts, fibrocytes and bundles of collagen fiber. The aggressive fibromatosis, although rare, should be differentiated from some other soft tissue tumors with similar histological features and different localizations of intra-abdominal, abdominal wall and extra-abdominal.     

Testosterone,aggressive behavior and dominance rank in captive adult male talapoin monkeys (miopithecus talapoin)

In three captive groups of talapoin monkeys, gonadectomized females usually ranked above males despite the larger size of the latter. Gonadectomized males sometimes ranked above intact ones. When gonadectomized females were treated with oestradiol some increase in aggression between the sexes occurred but this was not statistically significant. When gonadectomized males were treated with testosterone, however, they became more aggressive to subordinate males but not to more dominant males or females. Factors such as physical condition and previous social experience may be more important than gonadal hormones in influencing aggressive interactions in these captive groups of talapoins.     

Alterations in mouse aggressive behavior and brain monoamine dynamics as a function of age.

Male mice of the BALB, ICR and C57B1/6J strains were tested for conspecific aggressive behavior at either 6 or 30 weeks of age. Only the BALB animals were aggressive at 6 weeks of age while both BALB and ICR mice fought at 30 weeks of age. C57B1/6J mice did not show aggressive behavior at either of the time intervals studied. Changes in housing conditions altered the degree of aggressive behavior of the ICR but not the C57B1/6J mice. Whole-brain levels, rate constants (k) and utilization rates (K) of norepinephrine (NE) and dopamine (DA) in these mice were fluorometrically determined. C57B1/6J mice had significantly higher NE levels while BALB mice had higher DA levels, compared to the other strains at both time periods. The NE rate constants and utilization rates for C57B1/6J mice were lower at 6 weeks and higher at 30 weeks than either BALB or ICR mice as was the dopamine rate constant at the 6 week period. There was a tendency for BALB mice to have consistently higher DA utilization rates. These findings are discussed in relation to the catecholamine hypothesis of affective disorders.     

Radiation-induced undifferentiated pleomorphic sarcoma after radiation therapy for a desmoid tumour

Radiation-induced sarcoma is a long-term complication of radiation therapy. The most common secondary neoplasia is the undifferentiated pleomorphic sarcoma, which is usually described in the deep soft tissue of the trunk or extremities. Radiation-induced sarcomas have a poor prognosis. An early diagnosis and management are needed to improve the survival rate of such patients. We presently report a case of a radiation-induced undifferentiated pleomorphic sarcoma of the left gluteus maximus muscle, which developed 25 years after an initial diagnosis of aggressive fibromatosis and 21 years after a tumour recurrence. This case study illustrates the risk of developing a sarcoma in a radiation field and the need for long-term follow-up after radiation therapy. Unnecessary radiation therapy, in particular in the case of benign conditions in young patients, should be avoided.     

Reduced-Intensity Conditioning Followed by Related and Unrelated Allografts for Hematologic Malignancies: Expanded Analysis and Long-Term Follow-Up

Reduced-intensity conditioning (RIC) extends the curative potential of allogeneic hematopoietic cell transplantation (HCT) to patients with hematologic malignancies unable to withstand myeloablative conditioning. We prospectively analyzed the outcomes of 292 consecutive patients, median age 58 years (range, 19 to 75) with hematologic malignancies treated with a uniform RIC regimen of cyclophosphamide, fludarabine, and total body irradiation (200 cGy) with or without antithymocyte globulin and cyclosporine and mycophenolate mofetil graft-versus-host disease (GVHD) prophylaxis followed by allogeneic HCT at the University of Minnesota from 2002 to 6. Probability of 5-year overall survival was 78% for patients with indolent non-Hodgkin lymphoma, 53% for chronic myelogenous leukemia, 55% for Hodgkin lymphoma, 40% for acute myelogenous leukemia, 37% for myelodysplastic syndrome, 29% for myeloma, and 14% for myeloproliferative neoplasms. Corresponding outcomes for relapse were 0%, 13%, 53%, 37%, 39%, 75%, and 29%, respectively. Disease risk index (DRI) predicted both survival and relapse with superior survival (64%) and lowest relapse (16%) in those with low risk score compared with 24% survival and 57% relapse in those with high/very-high risk scores. Recipient cytomegalovirus (CMV)-positive serostatus was protective from relapse with the lowest rates in those also receiving a CMV-positive donor graft (29%). The cumulative incidence of 2-year nonrelapse mortality was 26% and was lowest in those receiving a matched sibling graft at 21%, with low (21%) or intermediate (18%) HCT-specific comorbidity index, and was similar across age groups. The incidence of grades II to IV acute GVHD was 43% and grades III to IV 27%; the highest rates were found in those receiving an unrelated donor (URD) peripheral blood stem cell (PBSC) graft, at 50%. Chronic GVHD at 1 year was 36%.Future approaches incorporating alternative GVHD prophylaxis, particularly for URD PBSC grafts, and targeted post-transplant antineoplastic therapies for those with high DRI are indicated to improve these outcomes.     

精神分裂症患者攻击行为的相关因素对照研究

目的　通过对住院精神分裂症有和无攻击行为患者资料的对照研究来探讨与精神分裂症患者攻击行为相关的因素。方法　收集住院精神分裂症患者的人口学和住院资料、BPRS、WCST、T3、T4、TSH等因子 ,用MOAS评定攻击行为并在有和无攻击行为组间分别进行显著性检验 ,然后通过回归分析 ,考察影响精神分裂症病人攻击行为的相关因素。结果　两组精神分裂症病人在BPRS、TSH、WCST等因子上存在显著差异 ,其中BPRS的敌意猜疑因子、诊断分型、TSH及WCST的持续错误数能够用于预测精神分裂症病人的攻击行为。结论　精神分裂症患者的攻击行为可能有精神病理学、神经心理学和神经内分泌学基础。     

脑出血急性期合并脑梗死的危险因素分析

目的 探讨脑出血急性期合并脑梗死的危险因素。方法 按照发病后2周内弥散加权成像(diffusion weighted image,DWI)上是否有新的脑梗死灶将125例原发性脑出血患者分为2组,比较临床资料的差异。结果 21例DWI阳性者脑叶出血发生率、颅内大动脉狭窄发生率、平均血肿体积显著高于38例DWI阴性者(P<0.05)。Logistic回归分析显示入院第1 d平均动脉压降低幅度(OR=7.384,P<0.001)、脑叶出血(OR=3.124,P=0.021)及颅内大动脉狭窄(OR=5.044,P=0.027)与脑出血急性期合并新发脑梗死灶呈正相关。结论 平均动脉压降低幅度、脑叶出血、颅内大动脉狭窄可增加脑出血急性期合并急性脑梗死的风险。