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71.
Asma Javed Peter J. Tebben Philip R. Fischer Aida N. Lteif 《Mayo Clinic proceedings. Mayo Clinic》2013,88(9):996-1009
As female athletic participation has increased, the positive effects of exercise on health have become evident. However, with this growth in sports activity, a set of health problems unique to the female athlete has emerged. The female athlete triad as first described in 1992 by the American College of Sports Medicine consisted of disordered eating, amenorrhea, and osteoporosis; the definition was updated in 2007 to include a spectrum of dysfunction related to energy availability, menstrual function, and bone mineral density. For this review, a comprehensive search of databases—MEDLINE In-Process & Other Non-Indexed Citations, MEDLINE, EMBASE, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, and Scopus, from earliest inclusive dates to January 2013—was conducted by an experienced librarian with input from the authors. Controlled vocabulary supplemented with keywords such as female athlete triad, amenorrhea, oligomenorrhea, fracture, osteopenia, osteoporosis, bone disease, anorexia, bulimia, disordered eating, low energy availability was used to search for articles on female athlete triad. Articles addressing the prevalence, screening, and management of the female athlete triad were selected for inclusion in the review. This article reviews the current definitions of the triad components, epidemiology, pathophysiology, and recommended screening and management guidelines. The lack of efficacy of current screening of athletes is highlighted. Low energy availablity, from either dietary restriction or increased expenditure, plays a pivotal role in development of the triad. Athletes involved in “lean sports” (those that emphasize weight categories or aesthetics, such as ballet, gymnastics, or endurance running) are at highest risk. Treatment is centered on restoring energy availability to reverse adverse changes in the metabolic milieu. Prevention and early recognition of triad disorders are crucial to ensure timely intervention. Caregivers and physicians of female athletes must remain vigilant in education, recognition, and treatment of athletes at risk. 相似文献
72.
Galimberti E Martoni RM Cavallini MC Erzegovesi S Bellodi L 《Progress in neuro-psychopharmacology & biological psychiatry》2012,36(2):307-312
Anorexia Nervosa (AN) and Bulimia Nervosa (BN) are complex Eating Disorders (EDs). Even if are considered two different diagnostic categories, they share clinical relevant characteristics. The evaluation of neurocognitive functions, using standardized neuropsychological assessment, could be a interesting approach to better understand differences and similarities between diagnostic categories and clinical subtypes in EDs thus improving our knowledge of the pathophisiology of EDs spectrum. This study explored cognitive flexibility and motor inhibition in patients with AN considering both Restricter and Binge/Purge subtypes, patients with BN and healthy comparisons subjects (HC). Intra-Extra Dimentional Set shifting Test and Stop Signal Task, selected from CANTAB battery, were administered to analyzed set-shifting and motor inhibition respectively. AN patients showed a deficient motor inhibition compared to HC, while no evidence for impaired motor inhibition was found in BN patients; a significant relationship between commission errors in the Stop Signal Task and attentional impulsiveness was found. Moreover, no difference in set-shifting abilities was found comparing all clinician groups and HC. So our results indicated no cognitive impairment in these two cognitive functions in BN patients, while AN and BN showed different performances in motor inhibition. A similar cognitive profile was found in other obsessive compulsive spectrum disorders. Finally, the paper suggests a new interactive approach for the study of cognitive profile in psychiatric disorders; it might be more useful since it is more closely related to the executive functions complexity. 相似文献
73.
Wei-an YUAN Zhi-bi SHEN Li XUE Wen-li TAN Ying-wu CHENG Song-hua ZHAN Hong-sheng ZHAN 《浙江大学学报(医学版)》2015,44(2):124
目的观察脊柱推拿治疗对腰椎间盘突出症患者脑功能活动的影响。方法招募11例腰椎间盘突出症患者,8例受试者完成了研究。所有患者接受6次腰部脊柱推拿治疗,并在脊柱推拿治疗前、后对患者进行颅脑功能核磁共振成像检测,评估患者脑功能活动的改变及与疗效关系。结果4例腰椎间盘突出症患者脊柱推拿治疗有效,4例无效。脊柱推拿有效患者治疗前、后产生视觉模拟评分(VAS)为50分时的疼痛压力值分别为(7.43±1.47)kg和(10.53±0.55)kg( P < 0.05),而无效患者的则无明显差异( P>0.05)。颅脑功能核磁共振成像检测结果提示,脊柱推拿治疗有效患者的脑功能活动以抑制为主,抑制区域主要位于右侧前额叶及小脑区域;而脊柱推拿治疗无效患者的脑功能活动以增强为主。 结论脊柱推拿能够影响腰椎间盘突出症患者的脑功能活动,其治疗有效患者的抑制区域主要在额叶及小脑。 相似文献
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76.
目的揭示重型胰腺炎发病机制和早期监测指标。方法对 12例重型胰腺炎 (SAP) ,15例轻型胰腺炎 (MAP)病人和 13例正常人 (N )的外周血用ELISA法测定IL -6及TNF ;用间接免疫荧光法测定CD4 、CD8 细胞。结果SAP组IL-6水平明显高于MAP组及N组 (P <0 .0 1) ,但MAP组与N组比较无差异 (P >0 .0 5 )。IL -6大于 10 0 pg/ml时预测SAP的敏感性为83 .33 % ,特异性 93 .33 % ;三组间TNF检出率无差异 ;CD4 百分率在SAP组明显下降 (P <0 .0 1)。SAP组IL -6与CD4 百分率呈明显负相关 (r =-0 .6 196 ,P <0 .0 5 )。结论SAP早期IL -6升高和细胞免疫功能抑制可能属其早期反应 ,测定IL -6有助于轻、重型胰腺炎的鉴别 相似文献
77.
目的了解C-erbB-2癌基因蛋白、表皮生长因子受体(EGFR)、转化生长因子-β1(TGF-β1)在人胰腺癌中的表达情况,探讨其与胰腺癌进展、转移的关系.方法应用SABC染色法对10例正常胰腺(NP)、13例慢性胰腺炎(CP)和36例胰腺导管腺癌(PC)石蜡组织切片进行C-erbB-2蛋白、EGFR,TGF-β1免疫组化染色.结果C-erbB-2蛋白、EGFR在NP中无表达,仅在一例CP中二者均阳性,在PC中阳性率分别为41.7%,50.0%;明显高于NP组和CP组(均P<0.05);TGF-β1在NP组、CP组、PC组阳性率分别为0.0%,7.7%和44.4%,PC组与前两组比较差异有显著性(P<0.05).三种蛋白单独表达与PC者的年龄、性别和肿瘤大小、部位及组织学分级无关(均P>0.05),与临床分期有关(P<0.01);三种蛋白共同阳性率为27.8%,其共同表达与肿瘤组织学分级、临床分期有关.结论检测C-erbB-2蛋白、EGFR和TGF-β1在胰腺组织标本中的表达,对判断胰腺癌的恶性程度、病程进展及转移趋势有参考价值. 相似文献
78.
类肝素聚乙烯醇复合材料抗凝血性能的研究 总被引:7,自引:0,他引:7
本文报道了聚乙烯醇羧甲醚(PC)、聚乙烯醇硫酸酯(PS)及聚乙烯醇接枝甲基丙烯酸β羟乙酯、丙烯腈(PVAgHEMAAN)的合成制备方法。通过红外光谱和元素分析定性、定量证实了合成方法的可行性。研究了将PC、PS以不同重量比加入PVAgHEMAAN后形成的聚乙烯醇衍生物复合材料(CDPVA)对抗凝血性能的影响。(CDPVA)对人血的溶血度仅为32%,人血复钙时间比空白对照延长202s,凝血时间延长1857s。SEM观察表明CDPVA接触血液一定时间后表面没有形成血液蛋白纤维网络,具有微相分离结构。 相似文献
79.
肝硬化患者血、尿β2-微球蛋白检测的临床意义 总被引:3,自引:0,他引:3
[目的]探讨肝硬化患者血、尿β2-微球蛋白(β2-MG)变化的特点及与肝脏功能的关系.[方法]143例肝硬化患者中按①肝炎后肝硬化、酒精性肝硬化分成两组;②按Child-Pugh分级标准分成三组.用放射免疫法检测143例肝硬化患者及126例正常人血、尿β2-MG浓度,并加以对比分析.[结果]肝硬化患者血清β2-MG较正常对照组明显升高(P<0.01),且与肝脏功能损害程度有相关关系;肝炎后肝硬化组血β2-MG明显高于酒精性肝硬化组(P<0.05).肝硬化患者尿β2-MG较正常对照组明显升高(P<0.01),且与肝脏功能损害程度有相关关系;但肝炎后肝硬化组尿β2-MG与酒精性肝硬化组比较,差异无显著性(P>0.05).[结论]检测血、尿β2-MG有助于肝硬化诊断,可间接反映肝病的活动程度. 相似文献
80.