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Zeinab Jahed Sara Molladavoodi Brandon B. Seo Maud Gorbet Ting Y. Tsui Mohammad R.K. Mofrad 《Biomaterials》2014
Metallic nanopillar/nanowires are emerging as promising platforms for biological applications, as they allow for the direct characterization and regulation of cell function. Herein we study the response of cells to a versatile nanopillar platform. Nanopillar arrays of various shape, size, and spacing and different nanopillar-substrate interfacial strengths were fabricated and interfaced with fibroblasts and several unique cell-nanopillar interactions were observed using high resolution scanning electron microscopy. Nanopillar penetration, engulfment, tilting, lift off and membrane thinning, were observed by manipulating nanopillar material, size, shape and spacing. These unique cell responses to various nanostructures can be employed for a wide range of applications including the design of highly sensitive nano-electrodes for single-cell probing. 相似文献
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Shinobu Nomura Hiroko Kojima PhD Yoshimi Ohyabu Kosuke Kuwabara Akihiro Miyauchi PhD Toshimasa Uemura PhD 《Journal of artificial organs》2006,9(2):90-96
Nanopillar sheets were fabricated with high-aspect ratio structures with a diameter of 160–1000 nm and a height of 1 μm by
nanoimprinting. The suitability of nanopillar sheets as a new type of cell culture dish was examined by studying the behavior
of HeLa cells cultured on the sheets using light microscopy, scanning electron microscopy, and fluorescence microscopy observing
actin and vinculin molecules. The nanopillar structure enabled easy subculture of the cells from the sheets without conventional
trypsinization. Moreover, the HeLa cells divided and proliferated on the sheets in a different way to that found on petri
dish because of the manner in which the cells adhered to the materials. 相似文献
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