芪参益气滴丸治疗冠心病不稳定型心绞痛临床观察

目的:观察芪参益气滴丸对冠心病不稳定型心绞痛患者的影响和安全性。方法:将60例冠心病不稳定型心绞痛患者随机分为治疗组和对照组各30例,两组患者均给予硝酸酯类制剂,β受体阻滞剂,阿司匹林肠溶片,调脂药物等常规综合治疗,治疗组在此基础上加服芪参益气滴丸,疗程4周。疗程结束评定中医症候、心电图及心绞痛指标。结果:治疗组心电图及心绞痛改善优于对照组(P0.05);治疗组中医症候改善优于对照组(P0.05);两组患者均未出现明显的不良反应。结论:芪参益气滴丸能改善冠心病不稳定型心绞痛患者的临床症状,提高临床疗效,且无不良反应,是治疗冠心病不稳定型心绞痛的有效、安全用药。     

应用ROC曲线评价高血压患者血清中的几项生化指标

目的 :利用ROC曲线研究TG、TC、UA、HDL-C、GLU及肥胖与高血压病的关系。方法 :各生化指标采用酶法检测 ,绘制高血压病患者和对照组比较的ROC曲线 ,评价各生化指标与高血压病间的相关程度。结果 :五项异常生化指标对高血压病的影响依次为 :UA >TC >TG >HDL-c>GLU。结论 :ROC曲线能较好地评价高血压病与危险生化指标的关系     

Improving the performance of virtual crossmatch results by correlating with nationally-performed physical crossmatches: Obtaining additional value from proficiency testing activities

Purpose

When donor specific HLA antibodies (DSA) are identified, the predictive value of whether a certain strength of reactivity (mean fluorescence intensity, MFI) leads to a positive crossmatch is uncertain. To determine this, we compared the DSA MFI results we generated locally for nationally distributed proficiency samples against the percentage of other laboratories reporting a positive crossmatch.

冠心病患者血清纤维蛋白原、超敏C反应蛋白、尿酸检测及意义

目的探讨纤维蛋白原(FIB)、超敏C反应蛋白(hs-CRP)、尿酸(UA)对冠心病的诊断、治疗及预后的临床指导意义。方法选择87例冠脉造影已经确诊的冠心病(CHD)患者且无严重感染、外伤、肿瘤等疾病为CHD组,根据临床分类分为稳定型心绞痛(SAP)、不稳定型心绞痛(UAP)、急性心肌梗死(AMI)三组。133例健康体检者为对照组,分别检测血清标本中FIB、hs-CRP、UA浓度。结果 CHD组血清FIB、hs-CRP、UA均高于对照组(P<0.05);FIB、hs-CRP、UA在SAP组、UAP组、AMI组依次均增高,差异有统计学意义(P<0.05)。结论 FIB、hs-CRP、UA血清浓度测定有助于指导临床医生CHD诊断、治疗、病情评估。     

Safety assessment of yerba mate (Ilex paraguariensis) dried extract: results of acute and 90 days subchronic toxicity studies in rats and rabbits

Acute toxicity of yerba mate dried extract (YMDE) was investigated in Wistar rats (6/sex/group) from single dose of 2g/kg body weight by intragastric administration and 14days monitoring. Subchronic toxicity was investigated in Wistar rats, by intragastric administration (10/sex/group), and in New Zealand rabbits by oral administration (3/sex/group) of 2g/kg body weight for 12weeks. Toxicological parameters included clinical signs, body weight, water, and food consumption, hematological and serum parameters, and histopathological assessment. Acute YMDE administration showed no effects on survival, clinical observations, macroscopic examination of organs, body weight or food, and water consumption. Sub-chronic administration of YMDE did not change behavior, body weight, and histopatological assessment of stomach, kidney, liver, and small gut. Moreover, most of biochemical and hematological parameters remained unchanged. In summary, the results of our preclinical toxicological investigation are indicative that the YMDE is well tolerated for both single and chronic administration.     

2型糖尿病患者TI水平相关因素分析

目的分析2型糖尿病患者空腹血清真胰岛素（TI）水平的变化趋势及临床意义。方法采用微粒子化学发光免疫分析法测定本院收治的68例糖尿病患者（观察组）空腹血清TI水平,与同期入院体检的68例健康志愿者（对照组）比较;并测定各组患者空腹血糖（FBG）、尿酸（UA）、C肽水平及胰岛素抵抗指数（HOMA-IR）,分析TI水平的改变趋势及临床意义。结果与对照组相比,观察组患者TI水平显著升高（P〈0.05）;且观察组患者血清FBG、UA、C肽及HOMA-IR水平均显著升高（P〈0.05）;经Pearson直线相关性分析,TI与血清FBG、UA、C肽及HOMA-IR水平均有直线正相关性（P〈0.05）。结论糖尿病患者TI水平异常增高,TI升高水平可反映血糖、尿酸代谢障碍,肾功能损伤程度及胰岛素抵抗水平,对糖尿病的临床诊断、治疗及预后评估有一定的指导意义。