Predictors of falls in older survivors of breast and prostate cancer: A retrospective cohort study of surveillance,epidemiology and end results—Medicare health outcomes survey linkage

Objectives

To identify predictors of falls in older breast and prostate cancer survivors.

Intensive Imaging Surveillance of Survivors of Breast Cancer May Increase Risk of Radiation-induced Malignancy

BackgroundCurrent clinical guidelines recommend mammography as the only imaging method for surveillance in asymptomatic survivors of early breast cancer (EBC). However, non-recommended tests are commonly used. We estimated the imaging radiation-induced malignancies (IRIM) risks in survivors of EBC undergoing different imaging surveillance models.Materials and MethodsWe built 5 theoretical models of imaging surveillance, from annual mammography only (model 1) to increasingly imaging-intensive approaches, including computed tomography (CT) scan, positron emission tomography-CT, bone scan, and multigated acquisition scan (models 2 through 5). Using the National Cancer Institute’s Radiation Risk Assessment Tool, we compared the excess lifetime attributable cancer risk (LAR) for hypothetical survivors of EBC starting surveillance at the ages of 30, 60, or 75 years and ending at 81 years.ResultsFor all age groups analyzed, there is a statistically significant increase in LAR when comparing model 1 with more intensive models. As an example, in a patient beginning surveillance at the age of 60 years, there is a 28.5-fold increase in the IRIM risk when comparing mammography only versus a schedule with mammography plus CT scan of chest-abdomen and bone scan. We found no differences when comparing models 2 through 5. LAR is higher when surveillance starts at a younger age, although the age effect was only statistically significant in model 1.ConclusionNon-recommended imaging during EBC surveillance can be associated with a significant increase in LAR. In addition to the lack of survival benefit, additional tests may have significant IRIM risks and should be avoided.     

Study to Assess the Rate of Adverse Reaction to Metal Debris in Hip Resurfacing at a Minimum 13-year Follow-up

BackgroundHip Resurfacing (HR), although reducing in popularity, is still used in the younger male population. Excellent medium-term results have been published; however, the use of metal on metal has reduced with increased awareness of adverse reactions to metal debris (ARMD). ARMD has been shown to often be clinically “silent” following large Head MoM total hip replacement (THR). The purpose of our study was to report the incidence of ARMD following HR with a minimum follow-up of 13 years.MethodsWe performed a retrospective study of a consecutive series of patients who underwent HR between January 1, 2000 and August 1, 2005. All patients were entered into our hospital MoM hip replacement surveillance program database. Patients were reviewed yearly for symptoms and blood ion levels. Patients had Magnetic Resonance (MR) imaging to assess for ARMD.ResultsA total of 102 patients with 123 hip replacements were included in the study. Eight hips in 7 patients were revised: two for fracture, one for avascular necrosis, and five for ARMD. A best-case scenario of 109 (93.2%) resurfacings were surviving at 13 years. With regard to the radiological analysis, 34% were found to have ARMD on MR.ConclusionWhile the implant survivorship in our series is acceptable, we found a high incidence of ARMD. Surgeons and patients with or considering a HR should be aware of the risk of ARMD developing. This allows an informed choice as to the best implant for their personal requirement and informs of the potential modes of failure and need for long-term screening.     

肿瘤随访现状与进展

肿瘤患者随访旨在获得肿瘤患者接受治疗后的疗效、康复状况、复发转移情况、生存质量、生存状态等信息,面这些信息已逐渐成为临床科研、医院管理不可或缺的部分.本研究从肿瘤随访的意义、现状、信息来源、随访内容、模式和方法、影响随访的因素等方面的做法和进展进行综述,为构建和完善肿瘤患者随访系统提供理论依据.     

国外癌症生存者照护模式研究进展及对我国的启示

随着癌症患者数量的日益增加,如何对癌症生存者进行照护和建立健全癌症生存者照护模式成为我国乃至全世界关注的焦点。我国癌症生存者照护模式仍处于起步阶段,癌症生存者照护存在缺陷且管理模式仍待改善。本文通过对国外癌症生存者照护模式进行梳理和总结,分析国外癌症生存者照护模式在流程优化、资源衔接、模式创新等方面的可借鉴之处,并结合我国癌症生存者照护现状,从分级诊疗、照护指南、人才建设、创新模式、制度政策方面提出建议,旨在为构建适合我国国情的癌症生存者照护模式提供参考。 该文的微信推文请扫描下方二维码查看！     

两种桡足虫在不同保存条件下生存状况的研究

目的 了解和掌握两种桡足虫在不同保存条件下的生存状况。方法 选取携带卵荚的Mesocyclops pehpeiensis和Megacyclops viridis雌虫分别置于室温干燥、冷藏干燥、室温潮湿扣冷藏潮湿环境，观察不同时间雌虫存活、卵荚孵化幼虫扣雌虫生长新卵荚以及新卵荚孵化幼虫等情况。结果 两种桡足虫在室温或冷藏条件下均不能在干燥情况下存活，但在潮湿情况下，两种桡足虫可在室温条件下至少可存活30d，在冷藏条件下至少可存活60d，并可以生长新的卵荚，孵出新的幼虫。结论 这两种桡足虫对干燥无耐受性，但在潮湿条件下至少可保存30～60d并保持其繁殖力。     

Survivorship and patient satisfaction of robotic-assisted medial unicompartmental knee arthroplasty at a minimum two-year follow-up

Background

Successful clinical outcomes following unicompartmental knee arthroplasty (UKA) depend on lower limb alignment, soft tissue balance and component positioning, which can be difficult to control using manual instrumentation. Although robotic-assisted surgery more reliably controls these surgical factors, studies assessing outcomes of robotic-assisted UKA are lacking. Therefore, a prospective multicenter study was performed to assess outcomes of robotic-assisted UKA.

The impact of BMI on quality of life in obese endometrial cancer survivors: Does size matter?

Background

Survivorship and quality of life issues are becoming increasingly relevant in endometrial cancer as a result of the marked increase in incidence of the disease combined with excellent and improving long term survival.

Objective

The purpose of this study was to evaluate the effect of obesity on quality of life (QoL) in endometrial cancer survivors.

Methods

Participants were endometrioid endometrial cancer survivors diagnosed between 2008 and 2013. Quality of life was measured through the European Organisation for Research and Treatment of Cancer (EORTC) quality of life questionnaire (QLQ-C30, version 3.0). Associations between BMI and quality of life were determined by means of multivariate analyses.

Results

322 women diagnosed with endometrioid endometrial cancer were invited to participate. Excluded were 15 women with unknown BMI, 40 with non-endometrioid histology and 10 with concurrent cancer. The QLQ-C30 questionnaire was completed by 158 (61.5%) women, of which 63 women (40%) were obese (BMI ≥ 30–39.9), and 30 women (19%) were morbidly obese (BMI ≥ 40). Morbidly obese women reported worse physical, role and social functioning and more somatic complaints.

Conclusion

Morbid obesity is associated with poorer quality of life in endometrial cancer survivors. Life style interventions such as exercise programs and diet interventions could be viable means to improve the quality of life of obese endometrial cancer survivors. Future research should focus on means to improve quality of life in obese endometrial cancer survivors.