全文获取类型
收费全文 | 19108篇 |
免费 | 1287篇 |
国内免费 | 549篇 |
专业分类
耳鼻咽喉 | 1556篇 |
儿科学 | 556篇 |
妇产科学 | 140篇 |
基础医学 | 2025篇 |
口腔科学 | 365篇 |
临床医学 | 2008篇 |
内科学 | 3720篇 |
皮肤病学 | 75篇 |
神经病学 | 3410篇 |
特种医学 | 288篇 |
外科学 | 736篇 |
综合类 | 2665篇 |
现状与发展 | 1篇 |
预防医学 | 879篇 |
眼科学 | 134篇 |
药学 | 1025篇 |
3篇 | |
中国医学 | 919篇 |
肿瘤学 | 439篇 |
出版年
2024年 | 41篇 |
2023年 | 294篇 |
2022年 | 712篇 |
2021年 | 1211篇 |
2020年 | 1096篇 |
2019年 | 641篇 |
2018年 | 770篇 |
2017年 | 806篇 |
2016年 | 720篇 |
2015年 | 655篇 |
2014年 | 1354篇 |
2013年 | 1316篇 |
2012年 | 1018篇 |
2011年 | 1196篇 |
2010年 | 918篇 |
2009年 | 1011篇 |
2008年 | 995篇 |
2007年 | 951篇 |
2006年 | 733篇 |
2005年 | 642篇 |
2004年 | 546篇 |
2003年 | 465篇 |
2002年 | 356篇 |
2001年 | 305篇 |
2000年 | 245篇 |
1999年 | 217篇 |
1998年 | 165篇 |
1997年 | 124篇 |
1996年 | 107篇 |
1995年 | 109篇 |
1994年 | 88篇 |
1993年 | 93篇 |
1992年 | 74篇 |
1991年 | 72篇 |
1990年 | 64篇 |
1989年 | 48篇 |
1988年 | 50篇 |
1987年 | 51篇 |
1986年 | 44篇 |
1985年 | 64篇 |
1984年 | 68篇 |
1983年 | 45篇 |
1982年 | 47篇 |
1980年 | 44篇 |
1979年 | 35篇 |
1978年 | 35篇 |
1977年 | 33篇 |
1976年 | 39篇 |
1975年 | 36篇 |
1973年 | 48篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
261.
263.
《Sleep medicine》2021
Obstructive sleep apnea is a common chronic disorder that leads to chronic intermittent hypoxia described as an important factor contributing to the pathogenesis of OSA-related comorbidities. Besides, recent data suggest that intermittent hypoxia can induce adaptative cardiovascular pathways inducing a relative resistance to ischemic insults. Adaptative pathways induced by hypoxia could implicate autophagic processes and Beclin-1, one of the first mammalian autophagy effectors. Thus, activation of autophagy could protect against cardiovascular events in patients with OSA and could be considered as biomarker of a better prognosis. 相似文献
264.
265.
A myriad of changes are necessary to adapt to chronic hypoxemia. Key among these changes increases in arterial oxygen carrying capacity, ventilation and sympathetic activity. This requires the induction of several gene products many of which are regulated by the activity of HIF-1α, including HO-1. Induction of HO-1 during chronic hypoxia is necessary for the continued breakdown of heme for the enhanced production of hemoglobin and the increased respiratory and sympathetic responses. Several human HO-1 polymorphisms have been identified that can affect the expression or activity of HO-1. Associations between these polymorphisms and the prevalence of hypertension have recently been assessed in specific populations. There are major gaps in our understanding of the mechanisms of how HO-1 mediates changes in the activity of the hypoxia-sensitive chemosensors and whether HO-1 polymorphisms are an important factor in the integrated response to chronic hypoxia. Understanding how HO-1 mediates cardiorespiratory responses could provide important insights into clinical syndromes such as obstructive sleep apnea. 相似文献
266.
267.
《Current medical research and opinion》2013,29(11):1839-1843
The acute coronary syndromes (ACS), consisting of ST-segment elevation myocardial infarction (STEMI), non-STEMI (NSTEMI), and unstable angina, remain a leading cause of death in the United States. Through the process of atherothrombosis, underlying atherosclerosis can progress to an acute ischemic coronary event. This disease mechanism is also common to ischemicstroke and peripheral arterial disease. As ACS is a heterogeneous disease, accurate patient diagnosis and risk categorization is essential. Treatment approaches for both STEMI and NSTEMI ACS consist of a combination of surgical intervention and pharmacotherapy, with antiplatelet agents such as clopidogrel, aspirin and glycoprotein IIb/IIIa receptor antagonists playing an essential role. 相似文献
268.
269.
270.