超声引导经皮穿刺活检与CA19-9联合检测对胰腺占位性病变的诊断价值

目的 :探讨超声引导下经皮穿刺活检与CA19 9联合检测对胰腺占位性病变的诊断价值。　方法 :对 30例超声检查怀疑胰腺占位性病变者行血清学CA19 9检测 ,并在体表B超引导下 ,用 18G或 19G切割活检针和 2 2G抽吸活检针行组织学和细胞学检查。　结果 :CA19 9诊断的敏感性为 92 % ,特异性 5 0 % ,准确性 92 %。超声引导经皮穿刺活检 30例患者总穿刺成功率为 93.3% (2 8/ 30 ) ,2 6例胰腺癌患者穿刺成功率为 92 .3% (2 4 / 2 6 ) ,活检阳性者 2 3例 ,其诊断敏感性为 88.4 % ,特异性 10 0 % ,准确性 88.4 %。CA19 9与超声引导经皮穿刺活检联合检测对胰腺占位性病变诊断的敏感性为 92 .3%、特异性 10 0 %、准确性 92 .3% ,与单行超声引导经皮穿刺活检比较有显著差异 (P <0 .0 5 ) ,而且对患者的治疗及预后有指导意义。穿刺结束后除个别患者有轻微腹痛外 ,无一例出现出血、胰瘘及胃穿孔等并发症。　结论 :体表B超引导下经皮穿刺与CA19 9联合检测对胰腺占位性病变诊断的敏感性、特异性、准确性较单一检测高 ,而且对患者的治疗及预后有一定价值 ,是一种安全、可靠的方法。     

大肠癌手术前后血清CA199和CEA水平变化临床价值的研究

目的:研究大肠癌患者手术前后(包括根治术及姑息手术)血清CA199和CEA水平的变化.并探讨其应用价值。方法:应用全自动化学发光免疫分析法,分别测定临床确诊的50例大肠癌患者(术前和手术30 d后)及50例正常成人血清CA199与CEA含量变化。结果:50例大肠癌患者手术前后血清CA199和CEA检测显示,术前血清CA199和CEA均高于对照组(P<0.01),术后血清CEA较CA199下降快,而且大肠癌患者术前血清CA199和CEA含量较根治术30 d后有明显增加,差异有统计学意义(P<0.05)。而姑息性切除手术前后血清CA199和CEA含量变化不大(P>0.05),差异无统计学意义。结论:大肠癌患者术前血青CA199和CEA含量显著增高.而根治术后血清CA199和CEA均有较明显下降。因此,术后定期联合监测血清CA199和CEA有利于临床观察大肠癌患者病情变化,评价手术效果,预测首程化疗疗效,为判断预后、及早发现术后复发病人提供依据。     

系统性红斑狼疮女性患者血清CA125,CA199化学发光法测定的临床应用

目的 :探讨系统性红斑狼疮 (SLE)女性患者血清肿瘤标志物CA12 5 ,CA199含量变化及临床意义。方法 :用化学发光法测定 30例正常女性和 38例SLE女性患者血清中CA12 5 ,CA199含量。结果 :正常组CA12 5含量为 11.14± 6 .4 8U/ml,CA199含量为 3.75± 2 .89U/ml;SLE组CA12 5 ,CA199分别为 2 2 .5 6± 2 0 .4 6U/ml,9.5 7± 9.34U/ml。SLE患者CA12 5 ,CA199阳性率分别为 2 1.1% ,7.89%。结论 :SLE患者血清CAl2 5 ,CA199含量较正常组增高 (P <0 .0 5 )。CA12 5 ,CA199在SLE女性患者中可出现阳性 ,对临床诊断SLE有一定价值。     

血清CA125检测对子宫内膜异位症的临床诊断价值

目的 :探讨血清CA12 5测定对术前子宫内膜异位症的诊断价值。方法 :99例子宫内膜异位症经腹手术前测定CA12 5水平 ,并与 90例作对照比较。结果 :子宫内膜异位症CA12 5阳性率 >3 5U /ml,为 5 7.5 7% ,对照组为 8.88% (P <0 .0 1)。内膜异位囊肿高于卵巢囊肿 (P <0 .0 1) ,子宫腺肌病高于子宫肌瘤 (P <0 .0 5 )。结论 :血清CA12 5测定对子宫内膜异位症有较理想的诊断价值 ,对异位囊肿与卵巢囊肿 ,子宫腺肌病与子宫肌瘤有鉴别意义     

Association analysis of CA repeat polymorphism of the endothelial nitric oxide synthase gene with essential hypertension in Japanese

The nitric oxide synthase (NOS) gene is thought to be associated with essential hypertension (EH), because NO is implicated in endothelium-mediated vasodilation. We investigated the possible association between the alleles of simple tandem repeat DNA polymorphism of the endothelial constitutive NOS (cNOS) gene and EH in Japanese subjects. In all, 100 patients with EH and 123 subjects with normal blood pressure were studied. Polymerase chain reaction was used to amplify the CA repeat site in the endothelial cNOS gene and alleles based on the CA repeat number were determined. The allele frequencies in the hypertensive group and normotensive group were then compared. Twenty-three alleles were identified in this study of Japanese subjects. The overall distributions of allele frequencies in the two groups were not significantly different. However, comparing the allele frequencies in the EH group without left ventricular hypertrophy (LVH) and the normotensive group, the overall distributions were significantly different (p = 0.019). The 33-repeat allele was found more frequently in the EH group without LVH than in the normotensive group (p = 0.000047, Odds ratio = 3.71). In conclusion, the 33-repeat allele of the endothelial cNOS gene is associated with EH without LVH, and may be a genetic marker of EH in Japanese subjects.     

卵巢甲状腺肿并发胸腹水及血清CA125升高1例报告

本文报告1例卵巢甲状腺肿并发胸腹水及血清CA125升高.     

CA125水平与肝硬化腹水定量及预后判断的关系探讨

目的探讨肝硬化患者CA125水平与腹水定量及预后的关系.方法肝硬化患者115例,84例伴有腹水,31例不伴有腹水;Child-pugh A级25例,B级53例,C级37例,健康对照组31例.用放射免疫法检测血清CA125水平,42例患者同时检测腹水CA125水平.对47例患者进行随访,其中25例有腹水,22例无腹水,结合CA125水平,观察腹水再发生的情况.结果肝硬化患者血清CA125显著高于正常对照组,并随肝硬化程度加重而进行性增加.伴有腹水患者血清CA125水平明显提高,与同一Child分级的无腹水患者相比有统计学意义.而且随着腹水量的增多,其血清CA125水平也呈逐渐升高趋势.CA125水平高且有腹水者腹水的再发生多,而CA125水平正常者腹水的再发生少.结论血清CA125水平对衡量肝硬化患者的预后和预测腹水再发生率有一定的参考价值.     

结核性胸水患者治疗前后检测血清CA125的临床价值

CA12 5在卵巢肿瘤诊断中已被广泛应用 ,并被证实对消化系统恶性肿瘤的诊断也有较好的参考价值 ;在胚胎组织发育中也可找到 ,属混合性肿瘤标志物[1 ] 。国外已有文献报道结核性腹膜炎患者血清CA12 5可明显升高[2 ] 。我们对结核性胸水患者血清CA12 5治疗前后水平的变化进行了临床分析。对象与方法1.对象 :3 6例均为我院收住院的结核性胸水患者 ,男性 2 1例 ,女性 15例 ,年龄 2 6～ 82岁 ,平均年龄 5 5岁± 13岁。依据陈灏珠主编的《实用内科学》第 10版的诊断标准确诊 ,并结合临床表现、X线胸片或CT、PPD试验 ,胸水ADA和抗结核治疗有效…     

CA125测定对某些妇科肿瘤的诊断意义

本文对４０名正常妇女和２０２名妇科肿瘤、宫内膜异位症的患者进行了血清ＣＡ１２５的测定。结果表明９８％正常妇女血清ＣＡ１２５水平＜５０ｕ／ｍｌ，行经期水平高于滤泡期、黄体期和绝经期水平。五组妇科疾病患者血清ＣＡ１２５水平也进行了测定，并观察了２１名卵巢癌患者ＣＡ１２５水平的变化情况。卵巢癌患者ＣＡ１２５水平最高，它与其它疾病组及正常对照组有明显的差异。血清ＣＡ１２５的测定在妇科临床上是有价值的。