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161.
目的:探讨计算机图像分析技术对乳腺肿瘤核仁组成区相关嗜银蛋白(AgNORs)表达在病理学诊断中的意义。方法:选取乳癌、乳腺结构不良、乳腺纤维腺瘤及正常乳腺组织各20例,应用图像分析系统和嗜银染色技术,对乳腺病变组织的AgNORs进行形态计量学分析,观察每个细胞的胞核面积、核周长以及AgNOR颗粒数目、颗粒面积、AgNOR的大颗粒数、形态因子、面积比值、平均面积等8项参数。结果:正常乳腺及乳腺结构不良、乳腺纤维腺瘤组织的细胞核面积、核周长以及AgNOR颗粒数目、颗粒面积明显小于乳癌组织(P<0.01),AgNOR的大颗粒数、形态因子、面积比值、平均面积在乳癌组织与乳腺纤维腺瘤及正常乳腺组织间差异有统计学意义(P<0.05)。上述8项参数4组间多类判别分析回代符合率为72.5%,癌和非癌的判别回代符合率达100%。结论:图像分析对于乳腺良、恶性病变的鉴别诊断具有重要价值,是一精确、客观的AgNOR定量研究手段。 相似文献
162.
颊鳞状细胞癌组织中血管内皮生长因子的表达 总被引:1,自引:0,他引:1
目的 :研究颊鳞状细胞癌 (颊癌 )组织中血管内皮生长因子 (VEGF)表达与颊癌细胞生长、转移及预后的关系。方法 :用免疫组织化学法对 37例颊癌标本进行染色 ,观察VEGF的阳性表达率 ,并结合病理和随访资料作统计分析。结果 :37例颊癌组织中VEGF的总阳性表达率为 91 .89% ,有淋巴结转移者VEGF强阳性占 69.2 3 % ,无淋巴结转移者VEGF强阳性占 33 .33 % (χ2 =6 .48,P <0 .0 1 ) ;VEGF和肿瘤浸润深度密切相关 (r =4.54 ,P <0 .0 1 ) ;5a生存组VEGF阳性率低于 5a内死亡组 (χ2 =3 .90 ,P <0 .0 5) ;COX分析结果表明VEGF可作为独立的预后判断指标 (风险比 =2 .90 ,χ2 =7.95 ,P <0 .0 1 )。结论 :VEGF在颊癌生长转移中发挥重要作用 ,可以作为颊癌预后的指标 相似文献
163.
目的 探讨使用猪尾造影导管与单一化疗药盒连接实现肝脏肿瘤多重化疗的可行性及初步疗效。资料与方法 对30例晚期肝脏恶性肿瘤患者采用经股动脉穿刺、腹腔动脉内植入猪尾导管与皮下埋置药盒并序贯化疗,统计手术成功率、并发症及临床疗效。结果 30例手术全部成功,发生切口延迟愈合1例。术后随访28例,经影像学复查对比,病变缩小7例,稳定12例,进展9例。随访期间12例患者死亡,术后生存期42d-10个月,中位生存期6个月。另外16例患者至今存活,已达术后2-16个月。结论 采用猪尾造影导管置于腹腔动脉并与化疗药盒相连接,能够对晚期肝脏恶性肿瘤实现多重化疗,技术上简单可行,并发症少,初步疗效令人满意。 相似文献
164.
165.
166.
Qin Fang 《中国脊柱脊髓杂志》1998,(4)
对有机硒和无机硒的测定进行了探讨,利用压榨提取无机硒,用荧光二阶导数法进行硒的定量测定,通过标准添加法对提取率进行了测定,回收率为93.2%~98.4%,变异系数为1.86. 相似文献
167.
Mixed dysembryoplastic neuroepithelial tumor and ganglioglioma 总被引:3,自引:0,他引:3
We report a case of a 15-year-old girl with new onset seizures, who had a mixed dysembryoplastic neuroepithelial tumor (DNT)
and ganglioglioma of the right parieto-occipital lobe. The tumor appeared well demarcated and exhibited a low T1 and a high
T2 signal on magnetic resonance imaging. Architecturally it was in large part intracortical and multinodular, but also featured
a leptomeningeal component. The former corresponded to DNT, a proliferation of oligodendroglia-like cells (OLCs) arranged
in nodules, as well as comprising a diffuse internodular element featuring “floating neurons” in a mucoid matrix. The leptomeningeal
portion of the lesion was a ganglioglioma consisting of large neurons and astrocytes in association with marked desmoplasia.
Spacially, the two components abutted one another but appeared distinct. Immunohistochemistry showed the neurons of the ganglioglioma
to be positive for class III β-tubulin, synaptophysin, and chromogranin A, whereas the astrocytic cells stained only for glial
fibrillary acidic protein. Most OLCs in the DNT were positive for S-100 protein. This apparently mixed lesion suggests that
a close histogenetic relationship exists between DNT and ganglioglioma. We postulate that the pluripotential progenitor cells
residing in the subpial granular layer may have given rise to the cortical DNT and to the leptomeningeal ganglioglioma. To
our knowledge, this is the first detailed histological, immunochemical and ultrastructural report of a mixed DNT and ganglioglioma.
Received: 11 August 1997 / Revised, accepted: 24 November 1997 相似文献
168.
依沙吖啶引产失败后用卡前列甲酯栓的疗效 总被引:2,自引:1,他引:1
目的:观察35例中期妊娠用依沙吖啶1次羊膜腔注射引产失败后,再用卡前列甲酯栓的效果。方法:卡前列甲酯栓1mg,放置于阴道后穹窿,若3h后无宫缩,再放1次。结果:35例孕妇引产成功率100%。引产后24h内阴道流血量200±20mL。出现腹泻,恶心等不良反应各1例。结论:卡前列7甲酯栓用于对依沙吖啶中期引产失败后效果满意。 相似文献
169.
We report two cases of a rare benign tumour of hair germ. Clinically, both were solitary, well-circumscribed, subcutaneous nodules located in the extremities. Histologically, the tumours were characterized by nests and thin cords of basaloid epithelial cells intimately associated with a cellular stroma. The basaloid cells exhibited peripheral palisading, keratinization in the form of keratotic cysts and squamoid transformation, and pilar differentiation. An unusual, but distinctive, cribriform pattern of growth was observed. There was no communication with the overlying epidermis. Abundant primitive hair germinal buds and rare more advanced abortive hair follicles were identified. These histological appearances encompass features of both trichoblastic fibroma and trichogenic trichoblastoma, thus distinguishing these neoplasms from other skin tumours and reinforcing the hypothesis that these tumours are closely related from a histogenetic point of view. The presence of overlapping histological features can be problematic for practising histopathologists who rarely encounter these conditions. With this in mind, the term benign trichogenic tumour may be more appropriate to encompass these two tumours and related neoplasms that appear to lie within the spectrum of hair follicle development. 相似文献
170.
T. W. Bax D. R. Marcus G. Q. Galloway L. L. Swanstrom B. C. Sheppard 《Surgical endoscopy》1996,10(12):1150-1153
Background: Laparoscopic adrenalectomy has recently been shown to be a safe and effective means of treating adrenal pathology with much
lower morbidity than the traditional approach. The majority of reports in the literature involve removal of adrenal tumors.
Although open bilateral adrenalectomy has been utilized for persistent Cushing's syndrome following attempted hypophysectomy,
there is little data available describing the application of laparoscopic adrenal surgery to this problem.
Methods: Four patients with persistent Cushing's syndrome after attempted treatment with hypophysectomy underwent laparoscopic bilateral
adrenalectomy at our institution. One procedure was done transabdominally in the supine position. Three procedures were done
transabdominally using sequential lateral decubitus positions.
Results: All procedures were completed laparoscopically. The mean operative time was 4.6 h (range 3.9–5.25). Repositioning and reprepping
the patients resulted in a slight increase in operative time, but visualization was improved using the lateral decubitus position.
Average blood loss: 156 cc (range 50–300). One patient required early reoperation for bleeding from the left adrenal bed,
which was controlled laparoscopically. Three patients were eating the following day and were discharged on postoperative days
1, 2, and 5. The fourth patient remained hospitalized for 18 days due to problems unrelated to surgery. After a mean follow-up
of 10 months, all patients have done well and have no clinical or biochemical evidence of recurrent disease.
Conclusion: Our clinical experience indicates that laparoscopic bilateral adrenalectomy is a viable treatment option for Cushing's syndrome
following failed hypophysectomy.
Received: 29 March 1996/Accepted: 12 June 1996 相似文献