A new method for the correction of secondary unilateral cleft lip nose

Summary In 1982, Dibbell described a procedure to correct this distortion by rotating and advancing the nostril medially and superiorly. We used this method in our department for several years, but as Dibbell himself experienced, we didn't always obtain satisfactory results. Like many authors, I agree that the best approach for proper correction of the secondary unilateral cleft lip nose deformity is the external approach using transcolumellar incisions, because the lower lateral cartilage exposure is inadequate with Dibbell's method. I added the transcolumellar incision similar to Bardach's to solve this problem. In this paper, this combination technique will be presented and contrasted with Dibbell's and Bardach's techniques.     

鼻部不同部位缺损的修复

目的：探讨鼻部分或全部缺损的手术修复。方法：根据鼻部不同范围的缺损选择不同的方式进行修复，包括邻近皮瓣、岛状皮瓣、复合组织游离移植等。结果：31例鼻部缺损组织瓣修复中鼻唇沟皮瓣13例，邻近滑行皮瓣8例，额部岛状皮瓣5例，耳廓复合组织游离移植5例均成活。术后鼻外形均满意。结论：鼻缺损修复方式较多，应根据缺损的部位，范围选择不同的修复方式。     

鼻腔外侧壁的应用解剖

在60个头颅(男34,女26)120侧鼻腔外侧壁上观察测量了以下诸结构,结果:上鼻甲长15.9±2.9mm,宽4.7±1.1mm;中鼻甲长36.5±3.3mm,宽10.4±3.4mm;下鼻甲长42.7±3.6mm,宽12.3±1.7mm;半月裂长16.6±2.3mm;钩突长20.7±3.1mm,宽4.3±1.7mm;筛泡长19.2±4.1mm,高6.5±2.1mm,另外还测量了前鼻棘距上述各结构的距离.     

The fat nose

The fat or sebaceous nose,^* with its thick, bulky skin filled with prominent sebaceous glands, is often improved surgically only by the use of external excisions of this tissue. The author describes several variations of this technique with representative cases.     

电子鼻技术应用于白及及其近似饮片快速辨识的可行性分析

目的：探讨电子鼻技术应用于白及及其近似饮片快速辨识的可行性。方法：收集134批白及及其近似饮片（白及45批、天麻30批、玉竹30批、黄花白及29批）作为待测样品,使用PEN3型电子鼻采集样品嗅觉感官数据作为自变量X,基于2020年版《中华人民共和国药典》和地方标准的鉴别结果,以及各饮片高效液相色谱法（HPLC）指纹图谱和原始采购信息,获得辨识模型的标杆数据Y,分别采用主成分分析-判别分析（PCA-DA）、偏最小二乘法-判别分析（PLS-DA）、最小二乘法-支持向量机（LS-SVM）及K-最近邻（KNN）4种化学计量学方法建立45批白及与89批非白及的二分类辨识模型和上述4种饮片的四分类辨识模型Y=F(X)。结果：经留一法交互验证,在二分类辨识中,上述4种模型分类正判率分别为97.01%、97.01%、98.51%和97.01%;在四分类辨识中,这4种模型分类正判率分别为97.76%、89.55%、98.51%和97.01%。二分类和四分类辨识模型的最高正判率均可达到98.51%,且均以LS-SVM算法为最优,最优核函数分别选择径向基核函数和线性核函数。最优模型判别结果良好,没有未分类样...     

基于电子鼻技术的不同品质鹿茸饮片气味特征分析

目的:基于电子鼻技术对不同品质鹿茸饮片气味特征进行分析与表征。方法:采用PEN3型电子鼻系统,分析22批鹿茸样品的气味特征,以对传感器响应值为指标,进行传感器区别贡献率分析(Loadings)、主成分分析(PCA)、线性判别分析(LDA)。结果:Loadings分析表明,5个传感器对鹿茸饮片气味特征具有较好的响应,不同规格鹿茸饮片气味差异贡献率主要体现为氮氧化物类、甲烷等短链烷烃、有机硫化物、醇醚醛酮类、芳香成分、无机硫化物等成分;PCA表明不同品种与规格鹿茸饮片,其气味的差异性比较明显;LDA发现不同品种及规格鹿茸饮片(除梅花鹿白片与粉片外)样品的气味差异均较明显,表明构成气味的物质存在差异性。结论:电子鼻技术可阐明不同品质鹿茸饮片气味的物质基础;不同品质鹿茸饮片气味存在差异性可揭示鹿茸饮片气味的科学内涵并为其质量控制提供参考。     

基于虚拟气体传感器阵列的新型肺癌检测电子鼻实验研究

本研究介绍了一种新型的基于虚拟气体传感器阵列及图象识别方法的新型无创肺癌检测与诊断电子鼻。该电子鼻包含一个由固相微萃取和毛细管柱组成的前处理装置实现病人呼吸气体中有机气体成分的浓缩吸附、脱附和分离,通过一个表面涂覆聚异丁稀薄膜差动结构的声表面波传感器对分离后的有机气体成分进行定量检测。此外,采用由毛细管柱方法实现的虚拟气体传感器阵列及改进的人工神经网络算法实现对肺癌呼吸气味图像的有效识别。通过临床实验验证,表明该电子鼻仪器可以有效地识别出肺癌患者、肺癌疑似病人和健康人,因此将有望在包括肺癌等疾病的早期诊断仪器中发挥重要的作用。     

朝鲜族人群鼻部肿瘤

[目的 ]了解朝鲜族的各种鼻部肿瘤的发病率并确定针对高发鼻部肿瘤的研究课题 .[方法 ]调查 1990年 1月到 1999年 10月之间在延边大学医学院附属医院病理科经活检确诊为鼻部肿瘤的全部患者的原始记录 .[结果 ]发现了 82例朝鲜族鼻部肿瘤患者 .其中 ,发病率最高的为乳头状瘤 ( 3 6/ 82 ) ,其次为鳞状上皮癌 ( 13 / 82 ) .[结论 ]朝鲜族鼻部乳头状瘤的发病率明显高于国内其它地区 .必须提高对鼻部乳头状瘤的诊断和治疗水平 ,并加快有关鼻部乳头状瘤和人类乳头状瘤病毒之间的关系的研究 .     

Effects of propylene oxide exposure on rat nasal respiratory cell proliferation.

Long-term exposure of rodents to propylene oxide (PO) induced inflammation, respiratory cell hyperplasia, and nasal tumors at concentrations >/= 300 ppm, suggesting a possible role for cytotoxicity and compensatory cell proliferation in PO carcinogenesis. In this study, the effects of PO exposure on histopathology and cell proliferation in nasal and hepatic tissues were studied in male F344 rats exposed by inhalation for 3 or 20 days (0, 5, 25, 50, 300, and 500 ppm). Histopathology revealed an increase in mucous cell hyperplasia in the anterior nasal passages after 20 days of exposure (>/=300 ppm). This was associated with the formation of goblet cell nests. Cell proliferation was measured in the respiratory epithelium (NRE; mucociliary and transitional) lining the anterior nasal passages, the nasopharyngeal meatus (NPM), and the liver using BrdU administered with 3-day osmotic pumps. Significant increases in cell proliferation occurred (>3.6-fold) in the mucociliary epithelium lining the anterior nasal cavity at and above 300 ppm for both exposure periods. In the mucociliary epithelium, the 20-day labeling was commonly associated with nests of goblet cells. Significant increases in cell proliferation (>2.3-fold) were observed in the transitional epithelium at 500 ppm after 3 days of exposure and at 300 and 500 ppm after 20 days of exposure. Significant increases in cell proliferation in the NPM (>2.8-fold) were evident at 500 ppm PO after 3 days and at 300 and 500 ppm PO after 20 days of exposure. No exposure-related changes in cell proliferation were observed in the liver. These studies demonstrate a clear concordance between the site and exposure concentration for tumor induction and those causing significant increases in cell proliferation in the rat nose.     

抗流感滴鼻剂不同除杂工艺微量元素的含量分析

目的：探讨不同除杂方法对微量元素含量的影响。方法：采用原子荧光法和电感耦合等离子体发射光谱法测定不同除杂方法所得澄清液中As，Hg，Pb，Fe，Mn，Zn，Cu的含量。结果：与原液比较，絮凝澄清液中As，Hg，Pb的去除率分别为57．1％，50．0％，39．6％，并分别为醇沉澄清液去除率的2．00，1．50，1．12倍；絮凝澄清液中的Fe，Mn，Zn，Cu保留率分别为90．6％，95．6％，91．7％，93．9％，并分别为醇沉澄清液保留率的1．09，1．29，1．15，1．28倍。结论：从有害元素的去除率及有益元素的保留率来看，絮沉工艺优于醇沉工艺。