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101.
Kyle R. Noll Catherine Sullaway Mateo Ziu Jeffrey S. Weinberg Jeffrey S. Wefel 《Neuro-oncology》2015,17(4):580-587
Background
Various tumor characteristics have been associated with neurocognitive functioning (NCF), though the role of tumor grade has not been adequately examined.Methods
Seventy-two patients with histologically confirmed grade IV glioma (n = 37), grade III glioma (n = 20), and grade II glioma (n = 15) in the left temporal lobe completed preoperative neuropsychological assessment. Rates of impairment and mean test performances were compared by tumor grade with follow-up analysis of the influence of other tumor- and patient-related characteristics on NCF.Results
NCF impairment was more frequent in patients with grade IV tumor compared with patients with lower-grade tumors in verbal learning, executive functioning, as well as language abilities. Mean performances significantly differed by tumor grade on measures of verbal learning, processing speed, executive functioning, and language, with the grade IV group exhibiting worse performances than patients with lower-grade tumors. Group differences in mean performances remained significant when controlling for T1-weighted and fluid attenuated inversion recovery MRI-based lesion volume. Performances did not differ by seizure status or antiepileptic and steroid use.Conclusions
Compared with patients with grade II or III left temporal lobe glioma, patients with grade IV tumors exhibit greater difficulty with verbal learning, processing speed, executive functioning, and language. Differences in NCF associated with glioma grade were independent of lesion volume, seizure status, and antiepileptic or steroid use, lending support to the concept of “lesion momentum” as a primary contributor to deficits in NCF of newly diagnosed patients prior to surgery. 相似文献102.
PET study and neuropsychological assessment of a long-lasting post-encephalitic parkinsonism 总被引:2,自引:0,他引:2
D. Caparros-Lefebvre M. Cabaret O. Godefroy M. Steinling P. Rémy Y. Samson H. Petit 《Journal of neural transmission (Vienna, Austria : 1996)》1998,105(4-5):489-495
Summary. A 76-year old woman was affected by lethargic encephalitis in 1918, at the age of 3 months. Long-term clinical follow-up
with late neuropsychological evaluation revealed post-encephalitic parkinsonism, which worsened very slowly and was improved
by levodopa. Obsessive and compulsive disorders (OCD) were associated to nosophobia. Neuropsychological evaluation showed
mild visuocontructional memory deficit, which was isolated. 18 Fluoro-Dopa PET demonstrated a severe bilateral and symmetrical
reduction in fluoro-dopa uptake, which was more marked in the putamen than in the caudate. Thus, the pattern of dopaminergic
denervation was similar to the one observed in idiopathic Parkinson's disease.
Accepted December 1, 1997; received May 9, 1997 相似文献
103.
Sophia Frangou Morgan Haldane Darren Roddy Veena Kumari 《Neuropsychopharmacology》2005,58(10):838-839
BACKGROUND: Trait functional abnormalities in BD patients have only been reported in the ventral prefrontal cortex (VPFC). We examined whether deficits in VPFC-related inhibitory processes, but not dorsal prefrontal (DPFC) based executive functions, represent an endophenotypic marker for bipolar disorder I (BDI). METHODS: We used the Wisconsin Card Sorting Test (WCST), commonly associated with DPFC function, and the Hayling Sentence Completion Task (HSCT) which engages the VPFC. Performance on these tests of 43 healthy participants was compared to that of 10 remitted BDI patients and 15 of their unaffected offspring. RESULTS: Compared to healthy participants, patients and their offspring made more errors in the HSCT but offspring achieved more categories and made fewer perseverative errors in the WCST. CONCLUSIONS: Impaired response inhibition, predominantly a VPFC related function, may reflect familial predisposition to BDI while deficits in rule attainment, a DPFC based function, may be associated only with the clinical phenotype. 相似文献
104.
105.
This study examined the relationship of neuropsychological deficits and negative symptoms with tardive akathisia in chronic schizophrenic patients. Consecutive volunteers (n= 100) were recruited from Community Health Centres with a DSM-III-R diagnosis of schizophrenic disorder, chronic and on stable medication. Subjects were subgrouped into tardive akathisia (TA), tardive dyskinesia (TD) and control groups using four sets of criteria. Detailed single examinations were performed using the following measures: sociodemographic, illness-related and treatment-related variables, Negative Symptom Rating Scale (NSRS), Abnormal Involuntary Movement Scale (AIMS), Rating Scale for Extrapyramidal Side-Effects (EPSE), Akathisia Rating Scale, Barnes Akathisia Rating Scale, and a brief neuropsychological test battery. Group comparisons and logistic regression analyses were performed in order to test the significance of findings. TA ratings showed a significant association with NSRS subscale scores, and with some neuropsychological test scores (Symbol Digits Modalities Test, and to a lesser extent Trail Making Test and Finger Tapping Test). TD scores showed a consistent association with age, and a less consistent association with gender, and their association with NSRS subscale scores and neuropsychological dysfunction was positive but less significant. Higher EPSE scores predicted TA and limb-truncal (LT) dyskinesia. In conclusion, TA showed a more significant association with some clinical indices of organic brain dysfunction than the oral-lingual-buccal-facial dyskinetic syndrome. Prospective studies are necessary to determine whether organicity is a vulnerability factor for TA. Both our data and the published literature suggest that the movement disorder seen in TA and TD is but one feature of complex syndromes that include motor and cognitive features. 相似文献
106.
Thomas P. Kelly Heather S. Borrill Deborah L. Maddell 《Child and Adolescent Mental Health》1996,1(2):46-51
There is increasing evidence that the development of the frontal lobes is a prolonged multi stage process continuing into adolescence. Research has indicated that damage to the frontal lobes may be detected from infancy. Downward extensions of tests from adult neuropsychology are not always suitable for use with infants and young children. There is a need to use tests in the routine neuropsychological assessment of children that have originated in cognitive developmental research. Executive and frontal functions are implicated in learning disabilities and several psychiatric disorders and therefore should be tested more frequently in clinical assessment. 相似文献
107.
Luke Clark Matthew J Kempton Antonina Scarnà Paul M Grasby Guy M Goodwin 《Neuropsychopharmacology》2005,57(2):183-187
BACKGROUND: Cognitive dysfunction persists in the euthymic phase of bipolar disorder and may provide a marker of underlying neuropathology and disease vulnerability. This study aimed to replicate a deficit in sustained attention in euthymic bipolar patients and investigate sustained attention in first-degree relatives of bipolar probands and in remitted patients with major depressive disorder. METHODS: The rapid visual information processing (RVIP) task was used to measure sustained attention in 15 euthymic patients with bipolar disorder and 15 control subjects in experiment 1 and in 27 first-degree relatives of bipolar probands, 15 remitted patients with major depressive disorder, and 46 control subjects in experiment 2. RESULTS: Sustained attention deficit was confirmed in the euthymic bipolar patients in experiment 1, but the deficit was not statistically significant in remitted major depressed patients or in the relatives of bipolar probands. CONCLUSIONS: A deficit of sustained attention is not present in patients with recurrent major depression tested during remission nor is it discriminable in the first-degree relatives of bipolar probands. Thus, the confirmed abnormality in euthymic bipolar patients may be acquired as a consequence of bipolar illness. However, future studies of relatives will require larger sample sizes to exclude or utilize small genetic effects. 相似文献
108.
Reviewed 53 studies on the effects of centred nervous systemprophylactic treatment (CNSPT) on cognition and neuropsychologicalfunctioning. CNSPT involves irradiation and/or chemotherapydirected to the brain, and is frequently administered to childrenwho have leukemia. The effects of CNSPT on neuropsychologicalfunctioning in long-term cancer survivors remains controversial.A number of studies failed to identify any neuropsychologicalimpact secondary to CNSPT, whereas others reported deficitsthat appear to be a function of CNSPT. Several methodologicalissues that make it difficult to draw meaningful conclusionsfrom this research literature are identified and discussed.Specific recommendations are made for improvements in researchon CNSPT in children. 相似文献
109.
M. von Aster M. Zachmann D. Brandeis G. Wohlrab M. Richner H. -C. Steinhausen 《European child & adolescent psychiatry》1997,6(4):227-233
This case report presents a thirteen year-old boy who was diagnosed as having Hypomelanosis of Ito. The developmental history includes severe failure to thrive, and moderate atypical autism as well as diverse clinical and neuropsychological symptoms are present. The pattern of neuropsychological functioning, which can be partially related to the neurophysiological findings, is discussed within the context of existing neuropsychological theories about autistic disorders. 相似文献
110.
Maretha de Jonge Chantal Kemner Fabienne Naber Herman van Engeland 《European child & adolescent psychiatry》2009,18(4):197-205
Superior performance on block design tasks is reported in autistic individuals, although it is not consistently found in high-functioning
individuals or individuals with Asperger Syndrome. It is assumed to reflect weak central coherence: an underlying cognitive
deficit, which might also be part of the genetic makeup of the disorder. We assessed block design reconstruction skills in
high-functioning individuals with autism spectrum disorders (ASD) from multi-incidence families and in their parents. Performance
was compared to relevant matched control groups. We used a task that was assumed to be highly sensitive to subtle performance
differences. We did not find individuals with ASD to be significantly faster on this task than the matched control group,
not even when the difference between reconstruction time of segmented and pre-segmented designs was compared. However, we
found individuals with ASD to make fewer errors during the process of reconstruction which might indicate some dexterity in
mental segmentation. However, parents of individuals with ASD did not perform better on the task than control parents. Therefore,
based on our data, we conclude that mental segmentation ability as measured with a block design reconstruction task is not
a neurocognitive marker or endophenotype useful in genetic studies. 相似文献