火焰原子吸收法测定野生与栽培地骨皮中的微量元素的含量

目的：考察野生与栽培地骨皮药材的微量元素含量情况。方法：收集不同产地野生与栽培地骨皮,采用微波消解处理样品,以火焰原子吸收光谱法测定样品中的Fe、Mn、Ca、Mg、K、Zn的含量。结果：测定了24批不同产地野生和栽培的地骨皮样品中Fe、Mn、Ca、Mg、K、Zn的含量,加样回收率在94.87%-96.93%之间。结论：不同产地野生和栽培地骨皮微量元素含量（除Fe元素外）无明显差异,所有样品均富含对人体有益的Fe、Mn、Ca、Mg、K、Zn等微量元素。     

微量元素作为甲醛损伤生物标志物的水平分析

目的：通过观测甲醛对小鼠肝脏、全血微量元素含量的影响,探讨甲醛损伤的生物标志物。方法：80只健康昆明小鼠随机分为对照组及甲醛染毒低剂量组（1/40LD50）、中剂量组（1/20LD50）和高剂量组（1/10LD50）,每组20只,采用吸入染毒方式,每天2　h,连续染毒3及6周后断头处死,分别测定小鼠肝脏和全血Cu、Fe、Zn、Mn的含量。结果：染毒3周高剂量组Fe、Zn、Mn含量及染毒6周中、高剂量组小鼠肝脏Fe、Zn含量明显低于对照组（P<0.05）,染毒3周高剂量组小鼠全血Mn、Zn含量明显低于对照组（P<0.05）,染毒6周后中、高剂量组小鼠全血Fe、Zn明显低于对照组（P<0.05）;染毒不同时间的各剂量组小鼠肝脏及全血Cu含量均无显著变化（P>0.05）。结论：甲醛可引起小鼠肝脏及全血Fe、Zn及Mn含量降低,Mn、Zn及Fe可作为甲醛损伤的标志物。     

Chronic Alcohol Abuse Alters Hepatic Trace Element Concentrations-Metallomic Study of Hepatic Elemental Composition by Means of ICP-OES

Trace element accumulation varies in different human tissues. Distribution of several elements was found to be disrupted in the case of excessive alcohol consumption, causing negative effects and exacerbation of pathological processes in the liver. In this study, we analyzed the levels and interactions between seven trace elements including calcium (Ca), cobalt (Co), chromium (Cr), copper (Cu), iron (Fe), potassium (K), and magnesium (Mg), manganese (Mn), sodium (Na), zinc (Zn), and selenium (Se) in individuals with alcohol-use disorder (AUD) and patients without AUD (control group). The liver samples were collected during autopsy from 39 individuals with AUD and 45 control subjects. Elemental composition inductively coupled plasma optical emission spectrometry (ICP-OES) after wet mineralization by nitric acid was applied for the evaluation of the samples. Positive correlations dominated in the AUD group, mainly in relation to Mg, which strongly positively correlated with Ca, Mn, Fe; K correlated with Mn and Zn, and Cu positively correlated with K and Zn. The strongest positive correlation in the AUD group was observed for the Mg-Mn pair (r = 0.87). Significant statistical differences (p < 0.05) between the groups concerned the average concentration of Co, Cu, Mn, and Mg, which were lower in the AUD group, and Fe, the level of which was significantly higher in the AUD group compared to the control group. Evaluation of the chronic alcohol consumption effect on the accumulation of trace elements in the liver allows a better understanding of the pathological processes taking place in this organ.     

首灵健脑胶囊对老年性痴呆小鼠学习记忆及脑内微量元素的影响

目的探讨首灵健脑胶囊对老年性痴呆小鼠学习记忆及脑内微量元素的影响.方法腹腔注射AlCl3复制慢性铝中毒老年痴呆模型,同时灌胃给予相应药物.给药结束后测试学习记忆成绩、脑系数和脑中微量元素的含量.结果跳台实验显示模型组较正常对照组的错误反应次数明显增多,测试期触电潜伏期明显缩短;给予首灵健脑胶囊或双氢麦角碱（喜得镇）的AlCl3小鼠与模型组比较,训练期和测试期跳台错误反应次数明显减少（P＜0.01）,测试期触电潜伏期明显延长（P＜0.01）.造模后小鼠的脑系数低于正常对照组（P＜0.05或P＜0.01）;中、高剂量的首灵健脑胶囊和喜得镇在使用后,可显著降低脑系数（P＜0.05或P＜0.01）.模型组小鼠脑中的微量元素Al、Zn、Mn、Ca、Cu、Fe与正常对照组比较,均有统计学意义（P＜0.01）;用药后,高剂量的首灵健脑胶囊和喜得镇可影响微量元素的含量（P＜0.01或P＜0.05）,中剂量的首灵健脑胶囊可显著影响部分微量元素的含量（P＜0.01或P＜0.05）.结论首灵健脑胶囊具有明显拮抗铝的神经毒性作用,通过维持脑内微量元素平衡发挥防治老年性痴呆的作用.     

Effect of Na-,Fe-,Co-,Cu-polygalacturonate on hemopoietic function in laboratory animals

The effects of water-soluble Na-,Fe-,Co-,Cu-polygalacturonate on hemopoiesis were studied in laboratory animals of various species, age, and functional groups. The compound had a strong positive effect on hemopoiesis, which manifested in an increase in hemoglobin concentration and erythrocyte count and rapid recovery of blood parameters after acute blood loss. __________ Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 143, No. 1, pp. 46–48, January, 2007     

胃癌、肠癌患者血清唾液酸、微量元素的分析

本文用原子吸收分光光度法测定了胃癌、肠癌、正常人血清中Cu,Zn,Fe,Mn,Ni的含量，并用改良硫代巴比妥酸法测定了其血清唾液酸（SA）的含量。结果表明：胃肠癌组血清Cu,Ni,SA,Cu/Zn比值明显高于正常人，血清Zn,Mn明显低于正常人。由此提示：血清唾液酸，微量元素的水平与胃癌，肠癌的发生有密切的关系。     

Evaluation of the microelement profile of Turkish hazelnut (Corylus avellana L.) varieties for human nutrition and health

In this study, the levels of boron (B), cobalt (Co), copper (Cu), chromium (Cr), iron (Fe), lithium (Li), nickel (Ni), selenium (Se) and zinc (Zn) microelements in 16 hazelnut samples were determined by inductively coupled plasma mass spectrometry and atomic absorption spectroscopy after microwave digestion, and are discussed for human nutrition and health. Significant differences were observed between the microelement contents of the 16 varieties (P < 0.01). The average microelements concentrations in the varieties varied in the following ranges: B, 13.63–23.87; Co, 0.47–0.82; Cr, 0.22–0.52; Cu, 16.23–32.23; Fe, 31.60–51.60; Li, 0.035–0.042; Ni, 0.58–2.58; Se, 0.96–1.39; and Zn, 22.03–44.03 mg/kg. These results showed that hazelnuts can be an important microelement source for human nutrition and health. According to our trace element data, a daily consumption of 50 g hazelnut can supply easily about 6% for B, 9% for Co, 19% for Fe, 9% for Ni and 16% for Zn of the recommended daily allowance. On the other hand, Se, Cu and Cr levels of 50 g hazelnuts are higher than the respective daily requirements, but slight overdoses of these elements are non-toxic for human health.     

小儿缺铁性贫血与全血微量元素关系的研究

目的：探讨小儿缺铁性贫血与全血微量元素关系。方法：120例缺铁性贫血患儿，抽血检测全血微量元素含量；并以80例健康小儿为对照。结果：120例缺铁性贫血患儿全血标本显示铜、锌、钙等微量元素均降低。而铅、镉等元素含量显著升高。结论：小儿缺铁性贫血与全血微量元素关系密切。     

成人脑组织中六种微量元素的含量及分布

目的：探讨人脑组织各微量元素的分布和含量。方法：采用原子吸收光谱法,测定了成人大脑额叶、枕叶、颞叶、中央前回、中央后回、海马回、延髓、脑桥、中脑和小脑中六种元素的含量。结果：脑组织中不同部位各种元素的含量依次为镁＞铁＞锌＞钙＞铜＞锰。结论：人脑组织中不同部位其微量元素的含量不同。     

微量元素缺乏与小儿慢性胃炎关系的临床探讨

目的探讨微量元素缺乏与小儿慢性胃炎的关系。方法对2007-07~2007-09哈尔滨医科大学附属第二医院门诊治疗的59例慢性胃炎患儿进行微量元素监测,对监测结果及其临床资料进行分析。结果59例慢性胃炎患儿中有48例微量元素缺乏,阳性率为81.4%。结论小儿慢性胃炎常合并微量元素缺乏,后者往往加重胃炎症状,建议在治疗小儿慢性胃炎时,补充微量元素以提高疗效。