Z分数质控图监测多台床旁血气分析仪室内质控的应用

目的探讨利用Z分数质控图监测临床科室多个床旁血气分析仪的室内质量控制情况,评估其应用效果。方法对分布于临床科室的多个床旁血气仪进行不同浓度质控品的测定,将每次的pH值、氧分压(pO2)和二氧化碳分压(pCO2)测定值转换为相应的Z分数,绘制Z分数质控图。结果通过计算而得的3个临床科室3台床旁血气分析仪Z分数可绘制出血pH值、pO2和pCO2的Z分数质控图,在12次测定中,3台仪器均无失控现象,可简洁清晰地反映不同仪器不同浓度质量控制的结果。结论Z分数质控图能将不同浓度、不同仪器的质控品测定值反映在同一张图上,简洁明晰,节约了质控成本,减轻了工作量,便于质控员监督检验科外仪器的分析质量。     

Vitamin E status in children with cystic fibrosis and pancreatic insufficiency

Vitamin E status was compared in 69 children (7.0-10.0 years) with cystic fibrosis and pancreatic with the National Health and Nutrition Examination Survey III sample (6.0-11.9 years). With median vitamin E intakes of 6 mg/day (dietary) and 224 mg/day (supplemental), children with cystic fibrosis had higher serum alpha-tocopherol:cholesterol ratios, higher alpha-tocopherol, and lower cholesterol levels than in the National Health and Nutrition Examination Survey.     

正常胎儿胸腺Z评分模型的研究

目的: 探讨胎儿胸腺横径、前后径、面积及周长随孕周增加的变化规律,建立20~38周正常胎儿胸腺Z评分模型。方法: 随机抽取2020年9月—2021年5月在河南中医药大学第三附属医院进行常规产检的单胎孕妇612例,测量胎儿胸腺横径、前后径、面积和周长,根据各测量值与孕周、双顶径（biparietal diameter,BPD）、股骨长的相关系数筛选评估胎儿胸腺大小的最佳指标,建立胎儿胸腺基于孕周、BPD、股骨长最佳预测回归方程和预测标准差（standard deviation,SD）回归方程,并根据公式Z=（胸腺实际测量值-预测值）/预测SD构建Z评分模型。结果: 胎儿胸腺横径、前后径、面积及周长的二维测量值均随着孕周的增加而增加,与孕周呈正相关（P<0.001）;其中胸腺横径与孕周的相关性最高（r=0.873,P<0.001）。胎儿胸腺横径与孕周、BPD、股骨长最佳拟合方程均为线性。成功建立了胎儿胸腺横径的预测回归方程和预测标准差回归方程,计算所得的Z值经Shapiro-Wilk检验均满足正态分布（P>0.05）。结论: 胸腺横径为评估正常胎儿胸腺大小的最佳二维指标,建立的胎儿胸腺横径的Z评分模型为产前评估胎儿胸腺发育情况及早发现胸腺发育异常相关疾病提供了依据。     

婴幼儿营养不良现况及Z值评价方法参考标准的研究进展

儿童是处于快速生长发育的特殊人群,儿童体格发育是评价儿童营养状况的一个重要指标。目前国际上通用z值法来评价儿童体格发育测量指标。应用z值法既能通过界值点的判断关注那些受影响较大的儿童,还能了解儿童群体的整体营养水平。现对使用该方法对婴幼儿营养不良现况做出的评价结果及其参考标准研究进展作一综述,以期为评价婴幼儿营养发育状况开阔思路。     

2010年饮用水中硫酸盐和铜质控结果分析

目的:为了更好的提高全省疾控中心实验室在饮用水方面的检测水平。方法:依照《生活饮用水标准检验方法》(GB/T5750.5/6-2006)对应方法对合成水样中硫酸盐和铜进行质控考核。用Z比分数统计评价检测结果,分为满意、可疑和不满意3种。结果:此次对全省18个地市和55个县市疾控中心共73个实验室进行水质检验质量控制考核,硫酸盐测定结果满意的57家,占78.1%;结果可疑的8家,占11.0%;结果不满意的8家,占11.0%。铜测定结果满意的64家,占87.7%;结果可疑的8家,占11.0%。结果不满意的1家,占1.3%。结论:全省各级疾病预防控制中心硫酸盐、铜总体检测能力较高,少数实验室检测能力有待提高。     

Pediatric nephrology patients are overweight: 20 years' experience in a single Canadian tertiary pediatric nephrology clinic

Background Obesity is an independent risk factor for chronic kidney disease (CKD). We compared the body composition of pediatric nephrology patients with that of the general child population over 2 decades. Methods About 4,959 patients above 2 years of age (mean: 9.6 ± 4.5) were referred to a tertiary pediatric nephrology clinic from 1985 to 2006. In 3,422 patients (69.0% with the same mean age) there were sufficient data to analyze body composition, expressed as body mass index (BMI) Z-score and calculated on the basis of normal data taken from the National (USA) Center for Health Statistics (2000). Results Hematuria (21.68%), recurrent urinary tract infections (16.09%), proteinuria (13.95%) and hypertension (8.27%) were the most common referral diagnoses. Mean BMI Z-score of the pediatric nephrology patients increased significantly from 0.29 ± 1.07 during the years 1985–1991 to 0.44 ± 1.27 in 1992–1999 and 0.87 ± 1.70 in 2000–2006 (P < 0.0001, ANOVA). Whereas the rate of the increase in BMI Z-score was not statistically different from that seen in the normal population, the young nephrology patients had over the entire time consistently significantly higher BMI Z-scores (average +0.72) than the comparable normal USA data. Several disease groups with potential for development of CKD had higher BMI Z-scores than found in the age- and sex-adjusted control data. Conclusions The increased rate of obesity in our studied population suggests that pediatric nephrology patients are at even greater risk for developing CKD later in life than could be predicted from their renal disease only. We recommend therapeutic intervention to address this potentially modifiable risk factor.     

Randomized Controlled Trial of A 12-Week Yoga-Based (Including Diet) Lifestyle vs. Dietary Intervention on Cardio-Metabolic Risk Factors and Continuous Risk Score in Indian Adults with Metabolic Syndrome

Abstract

Metabolic syndrome, a prediabetic and precardiovascular pathologic condition that begins early in life, tracks into adulthood and magnifies with age. Randomized controlled trials evaluating efficacy of yoga-based lifestyle vs. dietary intervention on metabolic syndrome are lacking. Here, the efficacy of a 12-week yoga-based lifestyle intervention vs. dietary intervention on cardio-metabolic risk factors and metabolic syndrome risk scores have been assessed in Indian adults with metabolic syndrome. In this two-arm, open label, parallel group, randomized controlled trial, 260 adults (20–45?years) diagnosed with metabolic syndrome as per joint interim statement, 2009 were randomized to yoga-based (including diet) lifestyle or dietary intervention alone (n?=?130, each) for 12?weeks. Primary endpoints were the 12-week changes in cardio-metabolic risk factors and metabolic risk scores. The secondary endpoints were the 12-week changes in the proportion of subjects recovered from metabolic syndrome, dietary intake, and physical activity. Intent-to-treat analysis was performed including all the subjects with baseline data with imputed missing data. Treatment?×?time interaction showed yoga-based lifestyle intervention had a greater treatment effect over dietary intervention by significantly reducing waist circumference, continuous metabolic syndrome z-score, and dietary intake/day while significantly increasing physical activity. High-density lipoprotein cholesterol showed a significantly greater reduction following dietary intervention than yoga-based lifestyle intervention. A significantly greater proportion of subjects recovered from metabolic syndrome in yoga-based lifestyle (45.4%) vs. dietary intervention group (32.3%). A 12-week yoga-based lifestyle intervention is more efficacious than usual dietary intervention in improving cardio-metabolic risk factor and metabolic risk score in Indian adults with metabolic syndrome.