全文获取类型
收费全文 | 61215篇 |
免费 | 4815篇 |
国内免费 | 1198篇 |
专业分类
耳鼻咽喉 | 336篇 |
儿科学 | 3646篇 |
妇产科学 | 554篇 |
基础医学 | 2715篇 |
口腔科学 | 409篇 |
临床医学 | 10927篇 |
内科学 | 21780篇 |
皮肤病学 | 493篇 |
神经病学 | 1870篇 |
特种医学 | 2477篇 |
外国民族医学 | 4篇 |
外科学 | 6458篇 |
综合类 | 6694篇 |
现状与发展 | 6篇 |
一般理论 | 2篇 |
预防医学 | 2669篇 |
眼科学 | 600篇 |
药学 | 2667篇 |
24篇 | |
中国医学 | 866篇 |
肿瘤学 | 2031篇 |
出版年
2024年 | 167篇 |
2023年 | 1264篇 |
2022年 | 1717篇 |
2021年 | 2571篇 |
2020年 | 2603篇 |
2019年 | 2675篇 |
2018年 | 2488篇 |
2017年 | 2077篇 |
2016年 | 1972篇 |
2015年 | 2084篇 |
2014年 | 4092篇 |
2013年 | 4106篇 |
2012年 | 3026篇 |
2011年 | 3301篇 |
2010年 | 2685篇 |
2009年 | 2688篇 |
2008年 | 2756篇 |
2007年 | 2820篇 |
2006年 | 2599篇 |
2005年 | 2339篇 |
2004年 | 1928篇 |
2003年 | 1664篇 |
2002年 | 1468篇 |
2001年 | 1358篇 |
2000年 | 1110篇 |
1999年 | 1045篇 |
1998年 | 968篇 |
1997年 | 953篇 |
1996年 | 786篇 |
1995年 | 676篇 |
1994年 | 665篇 |
1993年 | 581篇 |
1992年 | 507篇 |
1991年 | 465篇 |
1990年 | 377篇 |
1989年 | 326篇 |
1988年 | 315篇 |
1987年 | 278篇 |
1986年 | 270篇 |
1985年 | 250篇 |
1984年 | 249篇 |
1983年 | 171篇 |
1982年 | 182篇 |
1981年 | 150篇 |
1980年 | 111篇 |
1979年 | 99篇 |
1978年 | 73篇 |
1977年 | 33篇 |
1976年 | 58篇 |
1973年 | 28篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
11.
OBJECTIVE: To establish if there is a role for gabapentin or nortriptyline in the treatment of chronic orchialgia. METHODS: Twenty-six consecutive patients with chronic orchialgia were seen in the chronic pain clinic by a multidisciplinary team. A pain questionnaire was completed prior to commencing either gabapentin or nortriptyline. They were reviewed at 3 months and a repeat questionnaire completed. A 50% improvement in pain was considered successful. RESULTS: Complete data was available for 19 patients. Overall, 61.5% of patients commenced on gabapentin and 66.6% of patients commenced on nortriptyline had a greater than 50% improvement in pain. Patients with post-vasectomy testicular pain were considered as a subgroup. None of these patients had a greater than 50% improvement in pain. However, 80% of patients in the subgroup with idiopathic chronic orchialgia had a greater than 50% improvement in pain. CONCLUSION: Although this is a small study, it appears that gabapentin and nortriptyline are effective in the treatment of idiopathic chronic orchialgia but not post-vasectomy pain. 相似文献
12.
Takayuki Murakami Atsushi Komiya Kunihisa Mikata Shigeki Kaneko Ichiro Ikeda 《International journal of urology》2007,14(3):240-241
Abstract: A 66-year-old man was referred to our hospital with chest discomfort and shortness of breath. Seven months previously he had undergone a laparoscopic left nephroureterectomy for a left renal pelvic tumor and was given two cycles of adjuvant chemotherapy (methotrexate, epirubicin and cisplatin). Echocardiogram showed an 8-mm sized mass extending from the right atrium into the right ventricle. On computed tomography, multiple lung tumors, as well as the right atrial and ventricular mass, were seen. The patient died of acute heart failure caused by right ventricular outflow obstruction. On autopsy, a right atrial and ventricular metastasis of the initial transitional cell carcinoma was found. The patient's cause of death was acute heart failure as a result of cardiac metastasis of his initial renal pelvic carcinoma. 相似文献
13.
Brigden Geoffrey Zanelli Giussepe Lahiri Avijit Raftery Edward 《European journal of nuclear medicine and molecular imaging》1990,16(11):795-799
A new, single bolus method of in vivo blood pool imaging using a technetium Tc99m phosphine isocyanide complex (DEPIC) which binds to pre-albumin was evaluated in volunteers (n=4) and patients (n=20). DEPIC was assessed for its safety and possible drug interactions. Its duration of action and quality of ventriculography were compared with imaging using standard in vivo red cell labelling (PYP) during two 3-h scanning periods 1 week apart. DEPIC had a mean plasma halflife of 3.3 h. The count rate over the left ventricle was initially 42% higher with DEPIC than with PYP. However, removal of DEPIC by the liver resulted in equivalent count rates by 1 h, and by 3 h PYP count rates were 22% higher than DEPIC. Immediately post injection mean (SD) difference in the left ventricular ejection fraction between the two methods was 2.4% (7.7%). Satisfactory DEPIC scans were obtained up to 2 h post injection, but by 3 h there was a mean difference of 13% (11.3%). DEPIC was found to be a safe alternative to red all labelling for blood pool angiography, suitable for routine work. The single bolus methodology and high initial count rates offer improved efficiency and a capability for truly emergency scanning. 相似文献
14.
我院治疗66例心间隔缺损的病例中,有4例合并哑性动脉导管未闭(简称PDA),发生率6%。全组病例术前均无PDA临床体征,1例术前再次复查心脏彩超时发现,其余3例均漏诊。1例先处理PDA,3例在纠正心内畸形同时处理PDA。心间隔缺损合并哑性PDA容易漏诊,但有其临床特点,手术可先处理PDA,或在体外循环下处理PDA。 相似文献
15.
Sintov Amnon Scott William A. Gallagher Kim P. Levy Robert J. 《Pharmaceutical research》1990,7(1):28-33
Epicardial antiarrhythmic drug administration was studied as a therapeutic approach for experimental ventricular tachycardia (VT) in an open-chest dog model. Lidocaine-polyurethane matrices (28%, w/w) were formulated as a model system. Matrices were placed on the left ventricular epicardium in each of 23 anesthetized open-chest dogs with ouabain-induced VT, to evaluate effectiveness in restoring sinus rhythm. Conversion occurred in all animals treated with matrices containing 300 mg or more of lidocaine after 1.5 to 7.0 min. The matrix lidocaine content correlated linearly with the time required for conversion to sinus rhythm (r = 0.75, P = 0.0002); irrespective of matrix size the myocardial/plasma lidocaine ratio was 20.1 ± 4.2 (mean ± SD) at the time of conversion. In a separate series of five dogs without ventricular tachycardia, systolic wall thickening measured with sonomicrometers after 5 min of controlled-release lidocaine administration (500- to 1000-mg matrix lidocaine content, 7.48 ± 3.49-mg/kg dose) was only minimally diminished (–14.1%) and this effect was observed only at the site of matrix placement on the anterior-apical epicardium. In contrast, intracoronary injection of 0.3 or 1.0 mg/kg of lidocaine-HCl resulted in complete elimination of wall thickening or replacement by systolic thinning. Thus epicardial administration of lidocaine from polyurethane matrices was an effective means of treating ouabain-induced ventricular tachycardia. Regional myocardial function in the vicinity of the matrices was modified to a very limited degree, supporting the view that the matrices can be used safely, without serious risk to ventricular contractile performance. 相似文献
16.
通过42例重型肺心病、7例轻型肺心病、16例肺心病伴发冠心病患者和30例正常人在静息状态下的左右心脏射血分数及其临床资料的分析表明,重型肺心病患者在病情的急性发作期,存在有不同程度的左心功能不全,而轻型肺心病患者则无左心功能不全的表现。表明慢性肺心病仅在病程晚期,才由以右心为主的疾病发展成为全心病。本文还对重型肺心病与肺心病伴发冠心病患者的左心功能进行比较,结果表明,肺心病伴发冠心病患者左室功能受损程度更为明显,双重病因导致的左室功能减退,常造成心肌更严重的损害而且不容易恢复。 相似文献
17.
S. Aziz L. A. Soine S. L. Lewis A. P. Kruse W. C. Levy K. M. Wehe D. P. Fishbien M. D. Allen 《Transplant international》1997,10(6):446-450
A review of factors contributing to early mortality after cardiac transplantation revealed that up to 25 % of deaths were
due to primary graft dysfunction unrelated to rejection or infection. In light of this finding, evaluation of a donor heart
with regard to its suitability for transplantation takes on added importance. In an effort to screen the suitability of donor
hearts in the region covered by the Northwest Organ Procurement Agency (USA), all donors are evaluated by two-dimensional
transthoracic echocardiography as part of the initial evaluation. A total of 110 donor echocardiograms were reviewed and an
attempt was made to correlate the 30-day outcome with the parameters measured. An unexpected finding was that the presence
of left ventricular hypertrophy in the donor heart was associated with an increase in the incidence of donor heart dysfunction
compared with donors with normal echocardiographic profiles (33 % vs 3 %, P = 0.007).
Received: 12 February 1996 Received after resision: 27 June 1997 Accepted: 14 July 1997 相似文献
18.
Bronwyn A. Kingwell Lisa Krause Stevo Julius 《Clinical and experimental pharmacology & physiology》1994,21(1):31-39
1. Left ventricular (LV) hypertrophy has been implicated in the reduction of baroreflex sensitivity present in hypertension. The aim of the current study was to investigate the mean arterial pressure-heart rate reflex (MAP-HR) in a model which induced left ventricular hypertrophy but no sustained blood pressure elevation. 2. Five mongrel dogs were exposed to transient blood pressure elevation of between 20 and 30 mmHg, through hindlimb compression using a pneumatic pressure suit, for 7 h per day, 6 days per week for 6 weeks. Resting blood pressure was not altered by the 6 week hindlimb compression intervention. 3. Echocardiographically determined LV mass (mean ± s.e.m.) was 116.0 ± 7.4 g prior to hindlimb compression (baseline) and elevated to 125.4 ± 8.1 g (P= 0.003) after 6 weeks of compression. A reduction in the early (E) to late (A) transmitral diastolic flow ratio (E/A) from 1.80 ± 0.06 at baseline to 1.54 ± 0.09 (P = 0.037) after the 6 week intervention suggested that cardiac compliance was reduced. 4. The maximum gain of the MAP-HR reflex, studied using the ‘steady-state’ drug technique, when blood pressure was normal, showed a trend for reduction from 3.85 ± 0.43 beats/min per mmHg at baseline to 3.10 ± 0.45 beats/min per mmHg (P= 0.067) after 6 weeks of compression. This gain reduction became significant after β-adrenoceptor blockade with propranolol (3.13 ± 0.55 vs 2.32 ± 0.25 beats/min per mmHg; P= 0.039). Covariant analysis showed a significant inverse correlation between LV mass and maximum gain (r= 0.96; P<0.001) during the 6 week compression period. 5. The MAP-HR reflex changes in this model mimic those present in hypertension and implicate cardiac hypertrophy as one possible mediator. 相似文献
19.
本文对本地区五个县九所哈萨克族小学学生共计4125人进行了斜视、弱视的调查。调查对象全部为4—14岁哈萨克儿童。在受检儿童中发现斜视者48例,患病率为1.1%。外斜视32例占66.67%,内斜视16例占33.33%,斜视并有弱视者15例占31.25%。斜视而视力正常者33例占68.75%。在4125例受检儿童中发现弱视139例(209只眼),其患病率为3.37%,双眼弱视70例,单眼弱视69例,二者无显著差异。139例弱视中男性患者73例,女性患者66例,二者亦无差异。209例只弱视眼中轻度弱视84只眼占40.19%,中度弱视104只眼占49.76%,重度弱视21只眼共占10.05%。调查中笔者发现哈萨克族儿童弱视眼尤以屈光不正为多,209例眼中有106只为单纯性远视眼,因此笔者提出如何早期发现屈光不正并予以纠正将有可能防止许多弱视的发生。 相似文献
20.
This study investigated the relationship of protective factors (PF) to adult adaptation in a nonclinical sample consisting of 264 undergraduate women: two groups without childhood sexual abuse (CSA), high (n = 109) and low (n = 99) on PF; and two groups with CSA, high (n = 17) and low (n = 27) on PF. The first hypothesis that higher levels of PF would be significantly associated with higher levels of functioning for all individuals was supported by the data. The second hypothesis that the women with CSA and higher levels of PF would appear similar in adaptation to those without CSA was also supported. The findings further suggest that though the protective factors were beneficial for most individuals, they were significantly more helpful for those with CSA. 相似文献