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51.
《The Medical clinics of North America》2018,102(6):1121-1134
52.
Joseph H. Bochner Wayne M. Garrison Karen A. Doherty 《International journal of audiology》2015,54(7):490-498
Objective: The purpose of this study was to collect and analyse data necessary for expansion of the NSRT item pool and to evaluate the NSRT adaptive testing software. Design: Participants were administered pure-tone and speech recognition tests including W-22 and QuickSIN, as well as a set of 323 new NSRT items and NSRT adaptive tests in quiet and background noise. Performance on the adaptive tests was compared to pure-tone thresholds and performance on other speech recognition measures. The 323 new items were subjected to Rasch scaling analysis. Study sample: Seventy adults with mild to moderately severe hearing loss participated in this study. Their mean age was 62.4 years (sd = 20.8). Results: The 323 new NSRT items fit very well with the original item bank, enabling the item pool to be more than doubled in size. Data indicate high reliability coefficients for the NSRT and moderate correlations with pure-tone thresholds (PTA and HFPTA) and other speech recognition measures (W-22, QuickSIN, and SRT). Conclusion: The adaptive NSRT is an efficient and effective measure of speech recognition, providing valid and reliable information concerning respondents’ speech perception abilities. 相似文献
53.
IntroductionBulbar symptoms are frequent in patients with rapid-onset dystonia-parkinsonism (RDP). RDP is caused by ATP1A3 mutations, with onset typically within 30 days of stressor exposure. Most patients have impairments in speech (dysarthria) and voice (dysphonia). These have not been quantified. We aimed to formally characterize these in RDP subjects as compared to mutation negative family controls.MethodsWe analyzed recordings in 32 RDP subjects (male = 21, female = 11) and 29 mutation negative controls (male = 15, female = 14). Three raters, blinded to mutation status, rated speech and vocal quality. Dysarthria was classified by subtype. Dysphonia was rated via the GRBAS (Grade, Roughness, Breathiness, Asthenia, Strain) scale. We used general neurological exams and the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) to assess dysarthria, dystonia, and speech/swallowing dysfunction.ResultsThe presence of dysarthria was more frequent in RDP subjects compared to controls (72% vs. 17%, p < 0.0001). GRBAS voice ratings were worse in the RDP cohort across nearly all categories. Dysarthria in RDP was associated with concordant cranial nerve 9–11 dysfunction (54%, p = 0.048), speech/swallowing dysfunction (96%, p = 0.0003); and oral dystonia (88%, p = 0.001).ConclusionsQuantitative voice and speech analyses are important in assessing RDP. Subjects frequently experience dysarthria and dysphonia. Dystonia is not the exclusive voice abnormality present in this population. In our analysis, RDP subjects more frequently experienced bulbar symptoms than controls. GRBAS scores are useful in quantifying voice impairment, potentially allowing for better assessments of progression or treatment effects. Future directions include using task-specific diagnostic and perceptual voice evaluation tools to further assess laryngeal dystonia. 相似文献
54.
Emerging evidence suggests voice dysfunction is the earliest sign of motor impairment in Parkinson’s disease (PD). The complexity and fine motor control involved in vocalization may result in dysfunction here before the limbs. The voice in PD demonstrates characteristic changes on perceptual and acoustic analyses. The physiological and anatomical correlates of these have been investigated through laryngoscopy, stroboscopy, photoglottography, laryngeal electromyography, computed-tomography, pulmonary function testing and aerodynamic assessments. These have revealed numerous abnormalities including incomplete glottic closure and vocal fold hypoadduction/bowing to account for these voice changes. Many of these phenomena are likely related to rigidity or bradykinesia of the laryngeal muscles. The early onset of voice changes is resonant with the pathophysiological insights offered by Braak’s hypothesis and murine models of the disease. These physiological abnormalities and pathological models largely stand to support dopaminergic and non-dopaminergic mechanisms being implicated in the pathogenesis of voice dysfunction. This review focuses on characterizing the voice changes in PD. These stand as a promising area of enquiry to further our understanding of the pathophysiology of the disease and offer potential to be utilized as an early diagnostic biomarker or marker of disease progression. 相似文献
55.
Nina Enberg Juhani Wolf Anja Ainamo Hannu Alho Pekka Heinälä Marianne Lenander-Lumikari 《Acta odontologica Scandinavica》2013,71(6):341-347
A total of 85 Finnish alcohol-dependent subjects and 53 controls were studied with panoramic radiography. The aim was to study the possible associations between prolonged alcohol consumption and dental health. The mean number of teeth, caries lesions, endodontic treatments, periapical lesions, marginal bone loss, and periodontal infrabony pockets was studied. The subjects met the diagnostic criteria of alcohol dependence as set out in DSM-IV and ICD-10. The control group comprised social drinking volunteers with an AUDIT score h 8. For the final results the subjects were divided into groups on the basis of sex and age. The social backgrounds of the subjects were similar, except for employment and smoking. The results show significantly fewer teeth and more caries in the alcoholic group. There was a tendency for the alcoholics <45 years of age to have more endodontically treated teeth than the controls, but no difference in the number of periapical lesions in endodontically treated teeth was found. Horizontal bone loss and the presence of calculus were more frequent in alcoholic men than in alcoholic women. Significantly more horizontal bone loss was observed in the group of alcoholic nonsmokers than in nonalcoholic nonsmokers. In the nonsmoking groups alcoholics had significantly more periodontal destruction than the nonsmoking controls. We conclude that radiological dental health among individuals dependent on alcohol is weakened by more caries, more horizontal bone loss, and more numerous vertical infrabony pockets than social drinkers. 相似文献
56.
BackgroundThe state of the art for correcting velopharyngeal insufficiency (VPI) is a surgical procedure which is customized according to findings on imaging procedures: multiplanar videofluoroscopy (MPVF) and flexible videonasopharyngoscopy (FVNP). Recently, the use of MPVF has been challenged because of the potential risk of using ionizing radiation, especially in children.ObjectiveTo study whether using a protocol for performing MPVF can effectively decrease radiation dose in patients with VPI while providing useful information for planning surgical correction of VPI in combination with FVNP. The methodology used for performing the imaging procedures is described as well as the effectiveness of the surgical procedure.Material and methodsEighty - nine patients (Age range = 3–17 years; median = 5.5 years) with VPI resulting from multiple etiologies were studied. All patients underwent MPVF and FVNP for planning surgical correction of VPI. Radiation dosage data in each case was recorded. Forty of the 89 patients also completed a postoperative evaluation. Eleven out of the remaining 49 patients have not completed a postoperative evaluation and 38 patients are still pending surgical correction.ResultsRadiation dosage ranged from 1.00 to 8.75 miliSieverts (mSv); Mean = 2.88 mSv; SD = 1.575 mSv. Preoperative nasometry demonstrated mean nasalance ranging from 41%–95%; Mean = 72.30; SD = 4.54. Postoperatively mean nasalance was within normal limits in 36 (90%) out of 40 cases, ranging from 21% to 35%; Mean = 28.10; SD = 5.40. Nasal emission was eliminated postoperatively in all cases.ConclusionMPVF provides useful information for planning the surgical procedure aimed at correcting VPI. The combination of MPVF and FVNP is a reliable procedure for assessing velopharyngeal closure and to surgically correcting VPI with a highly successful outcome. 相似文献
57.
L. J. Kuipers-alting 《Clinical linguistics & phonetics》2013,27(3):209-219
In 1986, a research project was started in the Institute of Phonetic Sciences of Groningen University to investigate the pronunciation of English by hearing-impaired students in Dutch special secondary education. With the help of a tailor-made articulation test, we compare the pronunciation of English by these students to the pronunciation of English by students with normal hearing in ordinary secondary education. This article presents the results of 11 normal hearing and 11 hearing-impaired students on one of the items of our test: pronouncing a number of isolated words. Group I consists of five normal hearing and five hearing-impaired speakers in their first year at secondary school. Group II consists of three normal hearing and three hearing-impaired speakers from the second year intermediate level. Group III consists of three normal hearing and three hearing-impaired speakers from the second year lower level. It can be seen that more or less the same English sounds are regarded as difficult by both the hearing-impaired students and the normal hearing students, but that there is a much wider range of realizations within the groups of hearing-impaired students. 相似文献
58.
Phyllis Bonelli Maria Dixon Nan Bernstein Ratner Mark Onslow 《Clinical linguistics & phonetics》2013,27(6):427-446
The Lidcombe Programme of early stuttering intervention incorporates operant methods, and outcome data indicate that the procedure is an effective treatment. However, the mechanism or mechanisms responsible for the effects of this treatment remain unknown. One possible mechanism could involve untargeted change to parameters of parent and child speech during the intervention. In this preliminary report, speech samples from nine children were studied before and after treatment. The purpose was to target independent variables for future research. In spite of clear reductions in disfluency and stuttering in the children, there were no corresponding changes in child or parent speech rate, interspeaker turn latencies, or pragmatic functioning, that might account for such treatment effects. In fact, data suggested changes that would not be theoretically predicted to be associated with reductions in disfluent and stuttered speech: Maternal speech rate increased in post-treatment speech samples and the mothers decreased the proportion of their utterances that contained a request for information. However, some children's language measures did not meet developmental expectations during the period of study. Nonetheless, all children's language measures were within or above developmental expectancies during the period of study, which ruled out the possibility that this treatment induces extensive curtailment of language functioning. 相似文献
59.
60.
Hee-Sung Park Il Joon Moon Sun Hwa Jin Ji Eun Choi Yang-Sun Cho Sung Hwa Hong 《Clinical and experimental otorhinolaryngology》2015,8(3):237-242