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101.
102.
目的:总结对男性膀胱颈挛缩的诊治体会,方法:分析32例男性膀胱颈挛缩的临床特征及诊断要点,评价经膀胱切除颈部狭窄纤维环及前列腺的手术疗效,结果:术后平均尿流率及最大尿流率与术前比较均有显著性提高(P<0.01),随访3-12个月,临床症状消失,排尿满意,结论:男性膀胱颈挛缩要注意与前列腺增生症相鉴别,其中行膛胱镜检查是重要的鉴别手段。经膀胱切除颈部狭窄纤维环及前列腺是疗效可靠的治疗方法。 相似文献
103.
M. Di Rocco F. Callea B. Pollice M. Faraci F. Campiani C. Borrone 《European journal of pediatrics》1995,154(10):835-839
We report on five patients from three families with neurogenic arthrogryposis, cholestasis and tubular renal dysfunction. Despite a similar clinical picture the liver histology showed a broad pathological spectrum, ranging from pigment storage to parenchymal giant cell transformation and ductopenia. The findings are compared with those of other cases from the literature in search of a correct nosology of the syndrome characterized by arthrogryposis, renal and liver disease.Conclusion We propose to consider the picture of arthrogryposis, renal tubular dysfunction and cholestasis as a single syndrome. 相似文献
104.
目的:探讨增殖细胞核抗原(proliferatingcelnuclearantigen,PCNA)在膀胱移行细胞癌中的表达及其与预后的关系。方法:用抗PCNA的单克隆抗体PC10免疫组化染色常规石蜡包埋的膀胱癌组织。结果:全部48例膀胱癌标本中46例PCNA显示阳性(958%),正常膀胱组织均为阴性。PCNA指数在Ⅰ、Ⅱ、Ⅲ级肿瘤中分别为(828±868)%,(2382±1602)%,(4468±2465)%。在Ta~T1和T2~T4期肿瘤中分别为(1258±1233)%和(3455±2189)%。PCNA指数在各病理分级和分期间均有统计意义(P<0.01)。为了比较PCNA指数与生存率,根据PCNA染色平均水平,将患者分为两组即高PCNA组,其PCNA指数>21%和低PCNA组,其PCNA指数<21%。我们用Logrank方法对生存率统计发现高PCNA组的预后明显比低PCNA组的预后差(P<0.01)。结论:PCNA表达与膀胱癌病理分级、临床分期和预后均有密切关系,可作为膀胱癌一个有效的预后指标。 相似文献
105.
MR imaging of the male pelvis 总被引:2,自引:0,他引:2
Barentsz JO Engelbrecht MR Witjes JA de la Rosette JJ van der Graaf M 《European radiology》1999,9(9):1722-1736
Prostate and urinary bladder cancer are the most frequently encountered malignancies of the urinary tract. Appropriate use
of the different imaging techniques is crucial for accurate assessment of prognosis and for the development of appropriate
treatment planning. Especially determination of local tumor extension and detection of nodal or bone metastases is extremely
important. In this regard MR imaging is the most promising imaging technique. Therefore, in this review its role in staging
these malignancies is evaluated and compared with clinical staging, and other imaging techniques. Finally, future developments,
such as new sequences, new contrast agents, the role of surface coils and MR-guided biopsy, are considered. Also, the preferred
radiological approach is discussed. 相似文献
106.
Incorporation of bowel into the bladder (enterocystoplasty) has been widely used to increase bladder capacity. It has been
reported by others that the response of smooth muscle from the cystoplastic segment of the intestine shifts from that of the
intestine (relaxation to α-agonists and ATP) to that of the bladder (contraction to α-agonists and ATP). This suggests a functional
integration of the intestinal muscle into the bladder; the mechanisms are unknown. The aims of the present study were (1)
to elucidate if there are signs of bladder nerves sprouting across the anastomosis into the intestinal segment, and (2) to
study what happens with the intrinsic innervation of the intestinal segment. As a model, we used cecocystoplasty in rats.
The bladder was opened and a patch of cecum with intact vascular supply was anastomosed to the bladder. After two to 11 months
the rats were sacrificed and the bladders mounted as wholemounts and stained for acetylcholinesterase-containing nerves, or
embedded in paraffin for histology. A pronounced degeneration of the myenteric plexus was found in the cecal segments. In
some areas, this had proceeded to the extent that the ganglia were isolated ovoid lumps of cells with no apparent connection
to other ganglia. Areas lacking ganglia and nerve trunks but still with muscle could be found in all specimens. Abundant axon
bundles were demonstrated sprouting from the cut bladder nerves close to the anastomosis. The bundles spread out in a fan-like
pattern or were organized as fewer thicker nerves. There were many nerve bundles entering the cecal segment where they branched
and the diameter decreased till they no longer became visible. Some nerves reached surviving lumps of myenteric ganglion cells.
The results show that the bladder nerves sprout into the anastomosed cecal segment. It is reasonable to assume that these
nerves are responsible for the changes in receptor pharmacological properties of the cecal smooth muscle towards that of bladder
muscle.
Received: 30 October 1998 / Accepted: 18 May 1999 相似文献
107.
Madersbacher H 《Der Urologe. Ausg. A》1999,38(1):24-29
Summary
In neurogenic bladder dysfunction conservative treatment is preferred whenever possible and preservation of renal function
remains the main topic. Additionally, a patient-related form of bladder management with decreased intravesical pressure and
social dryness is needed. Therefore many strategies are available and after evaluation of the underlying neurogenic bladder
dysfunction an individual kind of treatment can be used. Possible options are the clean intermittent catherization, anticholinergic
drugs, detrusor triggering, electrical stimulation and bladder emptying by Valsalva's manouvre.
相似文献
108.
大鼠胰腺移植模型可用于解决临床移植中常见问题的初步探索性研究.采用目前临床胰腺移植常用的膀胱引流术式,建立大鼠的同种异体胰腺移植模型30例,其中12例存活超过5d,存活超过2周者6例,超过3个月者4例。尸检及病理结果表明,手术过程中血管吻合技术的熟练程度、吻合时间过长及移植胰腺冷缺血期间保存温度超过4℃而使之活力下降是移植后动物死亡的主要原因。 相似文献
109.
Stephen E. Jones Yuji Kasamaki Toshitsugu Ogura Lesya M. Shuba John R. McCullough Terence F. McDonald 《European journal of pharmacology》1999,370(3):863-327
The antispasmodic agent terodiline has cardiotoxic effects that include QT lengthening. To determine whether inhibition of inwardly-rectifying K+ current (IK1) might be a factor in the cardiotoxicity, we measured IK1 in guinea pig ventricular myocytes. Terodiline reduced outward IK1 with an IC50 of 7 μM; maximal reduction was 60% with 100–300 μM concentration. Inhibition was independent of current direction, and persisted after removal of the drug. Terodiline (3–5 μM) lengthened action potentials in guinea pig papillary muscles by ca. 10%, primarily by slowing phase 3 repolarization; higher concentrations abbreviated the plateau and markedly slowed late repolarization. Terodiline washout provoked an extra lengthening, consistent with persistent inhibition of IK1 and rapid recovery of net inward plateau current. The results suggest that inhibition of IK1 is a likely factor in the cardiotoxicity of the drug. 相似文献
110.
Purpose. Previous studies by other investigators have shown an enhancement of mitomycin C (MMC) activity at acidic extracellular pH (pHe) in monolayer cultures of human cells. The goal of the present study was to determine if the efficacy of intravesical MMC therapy in patients treated for superficial bladder cancer can be enhanced by using acidified dosing solutions. We evaluated (a) the effect of pHe on MMC activity in patient bladder tumors in vitro, and (b) the pH dependency of MMC activity in 2-dimensional monolayer and 3-dimensional multilayer cultures of human bladder RT4 tumor cells.
Methods. Patient bladder tumors were maintained as 3-dimensional histocultures. RT4 cells were harvested and maintained as monolayer cultures or as 3-dimensional cell pellets on a collagen gel matrix. The cell pellets were 300–450 cell layers and 4,000–5,000 µm in diameter. Tumors or cells were incubated for 2 hr with MMC-containing media at pHeof 5, 6, and 7.4. The drug effect was measured by the inhibition of DNA precursor (thymidine) incorporation. The stability of MMC as a function of pHe was determined. About 24% of MMC was degraded following 2 hr exposure at pHe 5 and 2% at pHe 6 and 7.4.
Results. The drug concentrations required to inhibit thymidine incorporation by 50% (IC50) were corrected for the degraded MMC at acidic pHe. The results showed no pH-dependent MMC activity in human patient bladder tumors nor in RT4 multilayer cultures; the IC50 values were about 10 µg/ml at all three pHe. In contrast, the monolayer RT4 cultures showed a pH-dependent MMC cytotoxicity; the IC50 were 0.1, 0.8 and 1.2 µg/ ml at pHe 5,6 and 7.4, respectively (p < 0.05). Pre-incubation of multi-layered RT4 cultures in acidic pH medium for 8 hr enhanced the MMC activity; the IC50 was reduced by about 5 fold at pHe 5 and about 3 fold at pHe 6. Similar pH-dependent MMC activity was found when multilayers were pre-treated for 1 hr with 0.5 µml nigericin, a proton ionophore known to cause the intracellular pH (pHi) to equilibrate with pHe.
Conclusions. These data suggest that the difference in the pH dependency of MMC activity in the monolayer and multilayer systems was due to the different experimental conditions. The time lag for pHi to equilibrate with pHe in the multilayer systems and the instability of MMC at low pHe imply that the efficacy of intravesical MMC therapy is unlikely to be enhanced by using acidic dosing solution. 相似文献