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Shabnam Sarwar Sejooti Sabikun Naher Md Mozammel Hoque Mohammad Shiblee Zaman H.M. Aminur Rashid 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2019,13(1):62-67
Insulin resistance (IR) is the corner stone of metabolic obesity. This cross-sectional analytical study was aimed to find out the frequency of IR in non-diabetic adult individuals of different obesity phenotypes that would help to implement preventive measures to avoid the cardiometabolic catastrophes.MethodsTotal 955 nondiabetic adult individuals were selected and categorized into six metabolic phenotypes by metabolic syndrome criteria in each BMI group (18.5–24.9-normal weight, 25-29.9-overweight, ≥30-obese). From them, metabolically obese normal weight, metabolically obese overweight, metabolically healthy obese and metabolically unhealthy obese were selected as Obesity phenotypes (N = 616).ResultsThe frequency of IR was found to be very high (60.2%) in total nondiabetic adult obese individuals (N = 616). Highest frequency of IR was found in MUO phenotype (76.3%), lowest frequency of IR was found in MONW phenotype (37.1%) and frequency of IR in MOOW and MHO phenotypes found to be identical but significantly (p < 0.0001) less than MUO and significantly (p < 0.0001) more than MONW phenotype. Among the obesity phenotypes, females were more insulin resistant than males (67.5% vs 48.1% respectively, p < 0.05). Frequency of IR found significantly (p < 0.05) more in female than male in all obesity phenotypes except in MUO phenotype where males found to show significantly (p < 0.05) higher frequency than females. Frequency of IR was significantly higher in younger (20–39 yrs) age group than 40–60 yrs age group (63.2% vs 53.5% respectively, p < 0.05).ConclusionIR is alarmingly high (60.2%) in nondiabetic adult obese individuals. Among different obesity phenotypes, it is highest (76.3%) in MUO and lowest (37.1%) in MONW. 相似文献
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Sedigheh Nouhjah Hajieh Shahbazian Nahid Shahbazian Shayesteh Jahanfar Alireza Jahanshahi Bahman Cheraghian Zeinab Dehghan Mohammadi Niloofar Ghodrati Sousan Houshmandi 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(3):317-323
Aims
This study aimed to determine the prevalence rate of metabolic syndrome and its potential risk factors, 6–12 weeks postpartum in women with GDM compared to women with normal glucose tolerance.Methods
LAGAs is an ongoing population-based prospective cohort study that started in March 2015 in Ahvaz, Iran. During 11 months of study progression, 176 women with GDM pregnancy and 86 healthy women underwent a fasting glucose test, 75-g OGTT and fasting lipid tests at 6–12 weeks postpartum. GDM was defined based on IADPSG criteria. Postpartum glucose intolerance was defined according to ADA criteria and metabolic syndrome using 2 sets of criteria.Results
The overall rate of metabolic syndrome at 6–12 weeks postpartum was 16% by NCEP-ATP III criteria (18.2% in women with GDM and 11.6% in controls) and 19.1% by IDF criteria (21% in women with gestational diabetes and 15.1% in controls). Pre-pregnancy overweight or obesity, (OR 1.89, 95% CI: 1.05-3.38, P?=?.03), pregnancy systolic blood pressure (OR 1.03, 95% CI: 1.008–1.52, P?=?.006) and requiring insulin or metformin (OR 3.08, 95% CI: 1.25–7.60, P?=?0.01), were associated risk factors for the presence of MetS in GDM-exposed women. In women with normal glucose during pregnancy, pre-pregnancy BMI ≥25?kg/m2 was a risk factor of metabolic syndrome (OR 2.82, 95% CI: 1.11–7.15, P?=?.02).Conclusion
The rate of metabolic syndrome in women with or without GDM at 6–12 weeks postpartum is high particularly in women with high BMI. An early postpartum prevention and screening program for cardiovascular risk factors is important for women with GDM. 相似文献50.
Nur Ezza Fazleen Maxine Whittaker Abdullah Mamun 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(6):1083-1090