Granular changes in vascular leiomyosarcoma

Summary A 78-year-old male presented a tumor mass in the left arm which was surgically excised. Part of the tumor, when examined by light microscopy, showed the characteristic cytological features of a leiomyosarcoma. Other areas of neoplasm comprised layers of tumoral spindle-cells surrounding abnormal blood vessels. Nests of similar neoplastic cells were observed in the intima and media of these blood vessels. Wide areas of neoformation were made up by interlacing bundles of acidophilic polyedral cells with large irregular nucleus. Mitoses were frequent. The cytoplasm contained a great number of granules intensely PAS stained with and without prior diastase digestion. Electron microscopic examination revealed that the granular cells possessed a continuous basal lamina, numerous pinocytotic vesicles and abundant 80–150 Å microfilament bundles. Within the microfilament bundles, as well as apposed to the plasma membrane, electrondense bodies were often found. Granules contained degenerated organelles and probably corresponded to digestive vacuoles. In the intercellular spaces, fibrous long-spacing collagen was seen. The transition zone between the leiomyosarcoma cells and the granular cells showed intermediate cell types, with few granules and abundant microfilaments. The origin of granular cells from smooth muscle cells of blood vessels is discussed.     

Granular cell tumor of the male breast: Report of a case

We treated a 35-year-old male with a granular cell tumor in the right breast. Physical examination revealed a solid, flattened, round 3.2 × 2.5-cm mass with an irregular surface, covering skin fixation and right axillary lymphadenopathy. Mammography revealed a well-demarcated high-density mass with a minimal starburst appearance. Ultrasonography revealed a hypoechoic, nonhomogeneous mass with an acoustic shadow. Several enlarged lymph nodes in the right axilla were removed at the time of breast tumor excision. Histologically, the tumor featured nests of round or polygonal cells with abundant eosinophilic cytoplasmic granules and small round nuclei, and the enlarged lymph nodes in the right axilla exhibited no metastasis. Immunohistochemically, there was positive staining for S-100 protein, neuron-specific enolase, and vimentin. The tumor also stained for macrophage CD-68, α₁-antichymotrypsin, and myoglobin. These immunohistochemical findings suggested the tumor cells to be undifferentiated mesenchymal cells which demonstrated the properties of neurogenic cells and histiocytes. Received: December 14, 1998 / Accepted: November 11, 1999     

皮肤颗粒细胞瘤1例及文献复习

患者女,56岁。发现左耳后质硬结节5月就诊。皮肤组织病理示:真皮层可见排列成巢状或束状的肿瘤组织,瘤细胞为多角形,胞浆丰富,淡粉染,充满嗜酸性颗粒。免疫组化标记CD34,CD68,S-100,Vimentin(+)。诊断:皮肤颗粒细胞瘤。治疗:采取完全手术切除。     

Particular tumor of the pancreas: A case report

BACKGROUNDGranular cell tumor (GCT) of the pancreas is a rare neurogenic tumor. The first case of pancreatic GCT was described in 1975, and up to now, only 7 cases have been reported.CASE SUMMARYA 53-year-old male had a pancreatic mass for 1 mo. He was not treated at the local hospital, but referred to Henan Tumor Hospital for surgery. Preoperative imaging revealed a 2.0 cm × 2.5 cm-sized mass located in the body of the pancreas. At the microscopic level, a large number of eosinophilic particles are present in the oval tumor cells. The immunohistochemistry of this tumor cell display CD56 (+), blood vessels CD34 (+), Ki-67 (+) < 10%, and S-100 (+).CONCLUSIONGCT of the pancreas should be recognized as a preoperative differential diagnosis of pancreatic tumors. Surgical resection of the tumor should be attempted; however, GCT of the pancreas has a certain rate of tumor metastasis and recurrence. Therefore, GCT of the pancreas requires regular and long-term follow-up.     

Granular cell brain tumors of the laboratory rat: an immunohistochemical approach

Summary We have studied paraffin-embedded specimens of 17 rat granular cell brain tumors (GCBT) from four long-term drug safety carcinogenicity studies by peroxidase-antiperoxidase (PAP) immunohistochemistry with either polyvalent or monoclonal antibodies against glial fibrillary acidic protein (GFAP), S-100 protein (S-100), Leu-7 epitopes, vimentin (VIM), keratin, desmin, and myelin basic protein. We have found that 9 of the 17 GCBT contained GFAP-positive, S-100-positive, and VIM-positive astrocytes, while GFAP-positive and VIM-positive granular cells were observed in 5 of these 9 tumors. Our findings indicate that astroglial cells are involved in rat GCBT and suggest that an astrocytic origin should be considered for these neoplasms.     

Abrikossoff’s rhabdomyoma presenting as a primary breast tumor: a case report

The granular cell rhabdomyoma, or myoblastoma, is commonly known as Abrikossoff’s tumor. It is a rare benign tumor thought to originate from the Schwann cell, and can occur anywhere in the body. When occurring in the breast, the clinical and radiological signs can mimic a primary breast carcinoma. Our case involves a patient who presented via the routine breast screening program. The combination of mammography and sonography suggested a malignant lesion. An ultrasound-guided microbiopsy of the suspicious nodule gave the diagnosis of a rhabdomyoma, and this was confirmed by immunohistochemical studies. The definitive histopathology result confirmed an Abrikossoff tumor, which was completely excised with clear margins of healthy breast tissue. The microbiopsy and immunohistochemical studies allowed the diagnosis to be confirmed and avoided any unnecessary surgery.     

Granular cell tumor of the trachea in pregnancy: a case report and review of literature

OBJECTIVES/HYPOTHESIS: The objectives were to present a case report of a woman with recurrent disease during consecutive pregnancies and to discuss the diagnosis and management of granular cell tracheal tumors, with particular attention to pregnancy and hyperestrogenic states. STUDY DESIGN: Case report and literature review. METHODS: A Medline search and comprehensive review of literature to assess all cases of granular cell tumors of the trachea were compared and collected, with particular attention to individual cases of pregnancy or cases related to the hyperestrogenic state. RESULTS: Thirty-two cases of granular cell tumors of the trachea were found. Only a few cases related to the hyperestrogenic state were obtained. The case report describes a woman with recurrent disease in subsequent pregnancies during the later stages of pregnancy. CONCLUSION: Few cases of granular cell tumors of the trachea have been reported, with even fewer being pregnancy related. The diagnosis and management of these tumors include careful attention to patient symptoms and airway management.     

Endoscopic finding of granular cell tumour associated with leiomyomas in the oesophagus

Following a single report in the literature of granular cell tumour associated with diffuse leiomyomatosis in the oesophagus, we describe the case of a 39-year-old man in whom a granular cell tumour and two leiomyomas were endoscopically removed from this site. This previously unreported association of granular cell tumour with isolated leiomyomas suggests the need to bear in mind the possibility of other mesenchymal lesions, including leiomyomas or leiomyomatosis, when a granular cell tumour is found in the oesophagus.     

卵巢颗粒细胞瘤预后影响因素的分析

目的 探讨卵巢颗粒细胞瘤临床、病理因素对预后的影响。方法 回顾性分析我院１９５８年至１９９５年收治的１００例卵巢颗粒细胞瘤患者的年龄、临床分期、核分裂相及早期患者的治疗方法选择等因素与预后的,并对复发与未复发患者,近期复发（〈１０年）与远期复发（≥１０年）患者进行比较。结果 全组总的５年和１０年生存率分别为８０％和７２％。不同年龄患者（≥４０岁,〈４０岁）的５年和１０年生存率,分别比较,差异无显著性（Ｐ〉０．０５）。临床分期为Ⅰ期者５年和１０年生存率分别为９８％和９６％,Ⅱ期分别为７０％和６０％,Ⅲ～Ⅳ期均为０％;外院治疗后复发或未控者５年和１０年生存率分别为５８％和４０％,分别比较,差异均有显著性（Ｐ均〈０．０５）。４７例有核分裂相计数的患者中,核分裂相〈５／１０高倍视野（ＨＰＦ）的５年和１０年生存率均为９６