慢性阻塞性肺病患者甲状腺功能的研究

本文通过对56例慢性阻塞性肺病患者血清FT_3、FT_4、TT_3、TT_4、rT_3和TSH的测定,对该病患者的甲状腺功能状态进行研究,并对20例同年龄组健康人对照。结果显示慢性阻塞性肺病(COPD)患者血清TT_3、TT_4较对照组明显减少;FT_3、FT_4无明显改变;rT_3及TSH有所增高。提示COPD患者甲状腺激素分泌量有一定程度减少(仍在正常范围内),并且存在着外周转换异常。血清FT_3、FT_4水平与正常对照组比较无明显差异,说明该病患者没有甲状腺功能减退。     

45岁以下出血性脑卒中患者血清水平动态变化对预后评估及影响因素分析

目的 探讨45岁以下出血性脑卒中患者人群血清FT3、FT4、TSH水平动态变化的流行病学特征,并对这些指标进行预后评估及影响因素分析.方法 选取2017年1月至2020年1月间,纳入成都市第六人民医院出血性脑卒中患者227例.收集并分析基线和随访12个月内预后(死亡,再出血,未见不良预后)相关信息;随访期间同时于治疗时...     

β‐turn formation by a six‐residue linear peptide in solution

Abstract: A model peptide AAGDYY‐NH₂ (B1), which is found to adopt a β‐turn conformation in the TEM‐1 β‐lactamase inhibitor protein (BLIP) in the TEM‐1/BLIP co‐crystal, was synthesized to elucidate the mechanism of its β‐turn formation and stability. Its structural preferences in solution were comprehensively characterized using CD, FT‐IR and ¹H NMR spectroscopy, respectively. The set of observed diagnostic NOEs, the restrained molecular dynamics simulation, CD and FT‐IR spectroscopy confirmed the formation of a β‐turn in solution by the model peptide. The dihedral angles [(φ₃, ?₃) (φ₄, ?₄)] of [(?52°, ?32°) (?38°, ?44°)] of Gly‐Asp fragment in the model peptide are consistent with those of a type III β‐turn. In a conclusion, the conformational preference of the linear hexapeptide B1 in solution was determined, and it would provide a simple template to study the mechanism of β‐turn formation and stability.     

Fourier Transform-Raman Spectroscopy for the Qualitative and Quantitative Characterization of Sulfasalazine-Containing Polymeric Microspheres

FT-Raman spectroscopy (FTRS) has been used to characterize microspheres produced from the pharmaceutical polymer Eudragit RS containing a range of concentrations of the drug sulfasalazine. While pure sulfasalazine produced an intense and complex Raman spectrum, the spectrum of drug-free Eudragit RS microspheres was considerably weaker in intensity and contained only a few prominent Raman scattering peaks. In spectra of the drug–polymer micro-spheres, peaks arising from the individual components could be identified. This enabled a quantitative analysis to be undertaken by calculating the ratio between the area of a sulfasalazine peak and the area of a Eudragit RS peak for each microsphere spectrum. A correlation was shown between the peak area ratio and the microsphere sulfasalazine content. FTRS was then applied to a series of microsphere samples which had been dissoluted into pH 7 buffer for 1, 3, 6, 9, 12, or 24 hr. For each spectrum, the drug-polymer peak area ratio was determined and this in turn enabled calculation of the residual drug content of the microsphere sample. FTRS-calculated data showed good agreement with microsphere drug content values determined spectrophotometrically.     

肝脏疾病患者游离甲状腺激素测定分析

目的分析肝脏疾病患者血清及浆膜腔积液游离甲状腺激素的变化。方法采用放射免疫法测定184例各型肝脏疾病患者血清及部分浆膜腔积液游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）的含量。结果随着肝病病程的加重,慢性活动性肝炎组、急性肝炎组、肝硬化组及肝癌组其血清中FT3、FT4水平呈下降趋势,肝癌组和肝硬化组显著低于急、慢性肝炎组（P〈0.05）,与正常对照组有非常显著性差异（P〈0.01）。漏出液组FT3、FT4含量显著低于渗出液组（P〈0.01）。结论血清FT3、FT4测定对肝脏疾病损害程度及预后具有应用价值,及对浆膜腔积液渗漏性鉴别也具有一定的价值。     

Graves病甲状腺血流多普勒与血清FT3、FT4的相关性

目的探讨超声血流多普勒与血清FT3、FT4对诊断Graves病的相关性。方法用血流多普勒超声检查对Graves病患者测量甲状腺上动脉舒张期内径、血流速度、阻力指数,并将检查结果与患者血清FT3、FT4检测结果进行相关性比较,同时与正常对照组比较。结果：Graves病患者超声血流多普勒检查所得双侧甲状腺上动脉的舒张期内径（D）,收缩期最大血流速度（PSV）,舒张末期血流速度（PDV）与甲状腺功能指标,尤其是FT4之间的呈一定相关性,相关系数为0．433—0．522。结论超声血流多普勒与血清FT3、FT4结合对诊断Graves病的定量诊断有一定价值。     

A comparison of fluency training and discrete trial instruction to teach letter sounds to children with ASD: Acquisition and learning outcomes

The study investigated the efficacy of fluency training (FT) and discrete trial instruction (DTI) to teach phonic reading to individuals with Autism Spectrum Disorder (ASD), with particular emphasis on the acquisition of correct letter-sound correspondence and the learning outcomes of behavioural fluency instruction. An alternating-treatment design was employed to compare the treatment effects of FT versus DTI for the acquisition, retention, stability, endurance, and application of phonics in four children with ASD. The results showed that for two participants, FT was more efficient for the acquisition of correct letter-sound correspondence. For the remaining two participants, DTI resulted in more rapid acquisition. For all four participants, FT produced better results during post-test retention, endurance, stability, and application checks. The implications of these findings are discussed in relation to reading instruction, as well as the use of rate-building procedures with individuals with ASD.     

非甲状腺疾病综合征对儿童甲状腺功能的影响和预后

目的 研究对于非甲状腺疾病综合征患儿而言,疾病对其甲状腺功能所造成的影响以及预后情况.方法 在医院所有患儿中,随机选取于2019年3月—2020年7月期间接受治疗并患有非甲状腺疾病综合征的患儿50例作为观察组,另选取未患有非甲状腺疾病综合征的患儿50例作为对照组,对比观察两组患儿的甲状腺功能正常率及炎性反应.结果 相较...