伊曲康唑加克霉唑软膏治疗复发性念珠菌性包皮龟头炎临床疗效观察

目的评价口服伊曲康唑治疗复发性念珠菌性包皮龟头炎的疗效与安全性。方法 45例患者口服伊曲康唑胶囊（商品名：斯皮仁诺）200mg,每日1次,克霉唑软膏涂于患处每晚1次,连续治疗7d,停药10d后,再巩固治疗7d。结果治疗完成后1周痊愈42例,显效2例,无效1例,痊愈率为93.3%,有效率为96.7%;治疗后2个月复查结果显示痊愈率为88.9%,有效率为93.3%;治疗结束后6个月复查结果显示痊愈率为88.9%,有效率为91.1%。结论口服伊曲康唑配合外用克霉唑软膏治疗复发性念珠菌性包皮龟头炎疗效满意,副作用小。     

氟康唑联合克霉唑阴道片治疗念珠菌性阴道炎

目的：评价氟康唑联合克霉唑阴道片治疗念殊菌性阴道炎的疗效。方法：将120名念珠菌性阴道炎患者分为3组。A组59例，采用氟康唑口服3d及单剂量克霉唑阴道片治疗。B组38例，采用氟康唑连续口服治疗3d。C组23例，采用单剂量克霉唑阴道片治疗。分别于治疗结束后第1周及第4周末复查，通过观察临床症状和体征、阴道分泌物涂片镜检评价疗效。结果：治疗后1周三组疗效比较差异无显著性（P〉0．05），治疗后4周A组疗效显著优于B组和C组（P〈0．05）。结论：氟康唑口服联合克霉唑阴道片治疗念珠菌性阴道炎远期疗效优于单一疗法。     

克霉唑阴道片治疗念珠菌阴道炎120例

目的:探讨克霉唑阴道片治疗念珠菌阴道炎的疗效.方法:用克霉唑阴道片治疗念珠菌阴道炎120例,分为初发组80例及复发组40例,初发者给药1次,复发者连用2次,2次用药间隔1周.结果:克霉唑阴道片治疗念珠菌阴道炎总有效率97.2%.症状完全缓解时间短,平均3 d.结论:克霉唑阴道片用药方法简单,无局部刺激症状,初发者单剂量应用基本无复发,值得临床推广应用.     

Chromatographic determination of clotrimazole, ketoconazole and fluconazole in pharmaceutical formulations

High-performance liquid chromatographic technique has been developed for the determination or some azolcsantifungals namely, clotrimazole (CZ), ketoconazole (KZ) and fluconazole (FZ), in pure forms and in pharmaceutical formulations. The proposed HPLC-method can be successfully applied as a stability indicating method for the determination of CZ in presence of its acid degradation products; viz (2-chlorophenyl) -diphenyl methanol and imidazole. The analyzed drugs were separated on a reversed-phase column [Bondapak™ C₁₈ (10 μm, 25 cm×4.6 mm, i.d.)] using a mobile phase containing acetonitrilc+25 mM trishydroxymeihyl aminomethane in phosphate butter (pH 7)=55:45 (v/v), with UV-detection at 260 nm. The differences in the retention times (t_R) of the three azoles permit their use as internal standard for each other. In addition, a coupled TLC-densitometric method has been also applied as a stability indicating method to separate and quantify CZ alone or in presence of byproducts impurities and/or its acid degradation products. The TLC-fractionation was performed on a precoatcd silica gel F₂₅₄ plates using a solvent system consisting of chloroform+acetone+ammonia (25%) (7:1:0.1, by volumes), CZ was well separated from its acid degradation products and quantified by densitometric scanning at 260 nm.     

褐藻胶浆在皮肤外用制剂中的应用：Ⅱ克霉唑胶浆乳的研制及临床应用

以天然海藻高分子原料褐藻胶作胶浆材料，将脂溶性的药物－克霉唑制成亲水性的胶浆乳，获得了稳定的制剂和满意的治疗效果。     

不同方案治疗妊娠期外阴阴道假丝酵母菌病的疗效比较

目的:比较4种方法治疗妊娠期外阴阴道假丝酵母菌病的效果。方法:将180例妊娠期VVC患者分为4组。凯妮汀单次用药组;凯妮汀2次组:凯妮汀1片/3d×2次;凯妮汀4次组:凯妮汀1片/3d×4次;凯妮汀2次+定君生组:凯妮汀1片/3d×2次,末次放药3d后开始定君生1粒/d×5d。治疗结束后7d复诊,评价有效率;治疗结束后28d复诊,评价复发率。结果:有效率为凯妮汀2次、4次组及凯妮汀2次+定君生组有效率均高于凯妮汀单次用药组,差异有显著性(P<0.05);凯妮汀4次组有效率高于凯妮汀2次组(P<0.05);凯妮汀2次+定君生组有效率与凯妮汀2次组相当;凯妮汀2次+定君生组有效率与凯妮汀4次组相当,2组间差异无显著性(P>0.05)。复发率为凯妮汀单次用药组与其他各组间复发率的差异无显著性(P>0.05);凯妮汀4次组及凯妮汀2次+定君生组的复发率低于凯妮汀2次组,差异有显著性(P<0.05);凯妮汀4次组与凯妮汀2次+定君生组比较,复发率差异无显著性(P>0.05)。结论:凯妮汀2次及4次疗法效果好于单次用药,4次疗法效果好于2次疗法,并且复发率较低。凯妮汀2次+定君生疗法效果及复发率均与凯妮汀4次疗法相当,但...     

pH指示剂吸收度比值法测定克霉唑的含量

本文报道pH指示剂吸收度比值法测定克霉唑的含量。该法采用指示剂为稀溴酚蓝,测定波长433nm和599nm;标准液为0.1mol/L盐酸;仪器为日本岛津260型分光光度计。应用本法测定5批克霉唑含量,同时与药典法比较,结果一致。     

外阴阴道假丝酵母菌病的两种治疗方法疗效观察

目的观察克霉唑阴道片联合克霉唑软膏治疗外阴阴道假丝酵母菌病(Vulvovaginal candidiasis)的效果。方法将外阴阴道假丝酵母菌病患者480例随机分为两组,治疗组用克霉唑阴道片联合克霉唑软膏,对照组单用克霉唑阴道片,比较其疗效。结果治疗组与对照组总有效率无统计学差异(P>0.05),但治疗组的复发率明显低于对照组,且能明显改善白带增多、外阴阴道瘙痒等症状(P<0.05)。结论霉唑阴道片联合克霉唑软膏对外阴阴道假丝酵母菌病的复发有明显的降低效果。     

伊曲康唑加克霉唑软膏治疗复发性念珠菌性包皮龟头炎临床疗效观察

目的:评价口服伊曲康唑治疗复发性念珠菌性包皮龟头炎的疗效与安全性。方法:45例患者口服伊曲康唑胶囊(商品名:斯皮仁诺)200mg,1次/d,克霉唑软膏涂于患处,每晚1次,连续治疗7天,停药10天后,再巩固治疗7天。结果:治疗完成后1周痊愈42例,显效2例,无效1例,痊愈率为93.3%,有效率为97.8%;治疗后2个月复查结果显示痊愈率为88.9%,有效率为93.3%;治疗结束后6个月复查结果显示痊愈率为88.9%,有效率为91.1%。结论:口服伊曲康唑配合外用克霉唑软膏治疗复发性念珠菌性包皮龟头炎疗效满意,副作用小。     

The frequency of Candida infections in pregnancy and their treatment with clotrimazole

Summary

In an open study, 243 pregnant women were investigated for Candida infection of the vagina. Clinical diagnosis, confirmed by culture, showed that 163 (56 %) were infected at some time during pregnancy. Infected patients were treated for 6 days with clotrimazole, 1 vaginal tablet per day plus cream applied externally. Treatment was considered as well accepted by all, and as successful in 84 % of cases in the first trimester, 87% in the second, and 78 % in the third trimester. There was no evidence of a relationship between Candida infection of the mother and the incidence of abortion or other disease of the newborn. It is suggested that early treatment of Candida infection of the vagina during pregnancy can greatly reduce the incidence of fungal infections in the newborn. In this series, only 3 of the 200 live births had a post-partum fungal infection: all were delivered by Caesarian section and the infection was not recorded until the third month in hospital.