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21.
In order to analyze the epileptogenic mechanisms of caffaine and related xanthines, putative effects of these drugs were studied on adenosine receptors of CA3 neurons in hippocampal slices. Epileptogenic concentrations of different xanthine derivatives strongly correlated with their affinities for the inhibitory A1 adenosine receptor subtype. The A1 receptor agonists adenosine and R-PIA reversibly depressed xanthine-induced epileptic activity without effects on the resting membrane potential or on spontaneously occuring action potentials. These findings suggest that the epileptogenic potency of xanthines is primarily due to the blockade of the A1 receptors through an abnormal rise of intracellular cAMP and to the excessive transmembrane calcium fluxes underlying paroxysmal depolarization shifts. 相似文献
22.
Akihiko Suto Akira Tsuyuki Nobuyoshi Hiraoka Yasuhiro Hosoda Kiyoshi Kikuchi Yasuo Fujishir 《Surgery today》1994,24(10):915-917
A case of cystadenocarcinoma of the appendix with a large cystic lesion is reported. A 49-year-old man undergoing a routine ultrasonic scan was incidentally found to have an abdominal mass measuring some 30 cm in size. The clinical presentation was asymptomatic, and the patient underwent a laparotomy without ascertaining a diagnosis preoperatively. The lesion, which derived from the appendix, was removed and was found to be cystic and contained huge amounts of mucin. The histological findings revealed a well-differentiated cystadenocarcinoma of the appendix, and immunohistochemical staining of the epithelium and mucinous implants in the mass demonstrated a positive reaction for carcinogenic antigens, including carcinoembryonic antigen and carbohydrate antigen. 相似文献
23.
Primary peritoneal carcinoma in a UK cancer center: comparison with advanced ovarian carcinoma over a 5-year period 总被引:1,自引:0,他引:1
K.S. JAABACK L. LUDEMAN† N.L. CLAYTON‡ & L. HIRSCHOWITZ† 《International journal of gynecological cancer》2006,16(S1):123-128
Abstract. Jaaback KS, Ludeman L, Clayton NL, Hirschowitz L. Primary peritoneal carcinoma in a UK cancer center: comparison with advanced ovarian carcinoma over a 5-year period. Int J Gynecol Cancer 2006; 16(Suppl. 1): 123–128.
The relative incidence of primary peritoneal carcinoma (PPCa) and advanced (FIGO stage III or IV) ovarian serous carcinoma (AOSCa) was assessed over 5 years at a UK cancer center, and the sociodemographic, clinical, and survival data were compared. There were 23 women with PPCa and 55 with AOSCa. The ratio of PPCa:AOSCa was higher than previously reported. No statistical difference was found between the two groups with regard to age (mean 64.43 vs 64.07 years, P = 0.9), parity (1.6 vs 1.8, P = 1.0), personal/family history of another malignancy (although five patients with AOSCa but none with PPCa had personal histories of breast cancer), or serum CA125, CA19.9, and carcinoembryonic antigen (CEA) levels. Similar numbers in both groups had malignant ascites, although 5.8% of patients with AOSCa but none with PPCa had negative cytology. Tumor grade, stage, treatment, and survival were similar (median 586 vs 641 days, P = 0.66). This analysis of the largest published UK series of patients with PPCa does not support previous reports that patients with PPCa are older than those with AOSCa and have a worse prognosis; it suggests that both groups have similar sociodemographic characteristics, clinical profiles, and survival. 相似文献
The relative incidence of primary peritoneal carcinoma (PPCa) and advanced (FIGO stage III or IV) ovarian serous carcinoma (AOSCa) was assessed over 5 years at a UK cancer center, and the sociodemographic, clinical, and survival data were compared. There were 23 women with PPCa and 55 with AOSCa. The ratio of PPCa:AOSCa was higher than previously reported. No statistical difference was found between the two groups with regard to age (mean 64.43 vs 64.07 years, P = 0.9), parity (1.6 vs 1.8, P = 1.0), personal/family history of another malignancy (although five patients with AOSCa but none with PPCa had personal histories of breast cancer), or serum CA125, CA19.9, and carcinoembryonic antigen (CEA) levels. Similar numbers in both groups had malignant ascites, although 5.8% of patients with AOSCa but none with PPCa had negative cytology. Tumor grade, stage, treatment, and survival were similar (median 586 vs 641 days, P = 0.66). This analysis of the largest published UK series of patients with PPCa does not support previous reports that patients with PPCa are older than those with AOSCa and have a worse prognosis; it suggests that both groups have similar sociodemographic characteristics, clinical profiles, and survival. 相似文献
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外阴尖锐湿疣人乳头瘤病毒感染的检测与分型 总被引:2,自引:0,他引:2
张秀华 《菏泽医学专科学校学报》2004,16(3):14-15
目的 了解患外阴尖锐湿疣人乳头瘤病毒(HPV)6型和11型的感染情况及PCR方法对尖锐湿疣诊断与分型的临床意义。方法 采用PCR方法测定160例尖锐湿疣患病题组织或分泌物中HPV6/11型及HPVl6/18型的感染率。结果 HPV6/11型感染率为95%(152/160),HPVl6/18型感染率为5%(8/160),HPV6/11型 HPVl6/18型混合感染率为1.3%(2/160)。结论 外阴尖锐湿疣患以HPV6型和11型感染为主。PCR方法是一种比较适合临床HPV检测与分型的极为敏感和特异的诊断方法。 相似文献
26.
Encephalopathy is a common complication of sepsis. However, little is known about the morphological changes that occur in the brain during sepsis. In this study, fecal peritonitis was induced in Wistar rats, which had been monitored for 4 h before their brains were removed and samples from the CA1 area taken. In addition to higher blood pressure with a decreasing pattern and a significant drop in rectal temperature, an increased heart rate and marked respiratory failure were observed. The tissue was investigated and compared with corresponding hippocampal samples taken from sham‐operated and not operated control groups. Significantly more peri‐microvascular edema was found in the hippocampal CA1 area in the septic group. The percentages of the peri‐microvascular edema were 158.57 ± 3.6%, 122.84 ± 1.5% and 120.24 ± 1.9% in the fecal peritonitis group, sham‐operated and not operated control groups, respectively. The results may suggest that the edema observed around the microvessels may participate in the pathogenesis of the septic encephalopathy probably by causing in the microvascular permeability characteristics. 相似文献
27.
联合测定子宫内膜异位症患者血清中EMAb及CA125的临床评价 总被引:6,自引:0,他引:6
目的:对联合测定子宫内膜异位症(内异症)患者血清中EMAb及CA125进行临床评价。方法:采取内异症109例术前(内异症组)和健康妇女30例(对照组)空腹静脉血,用酶联免疫吸附法(ELISA)测定两组血清中EMAb水平;用放射免疫法(RIA)测定血清中CA125水平。结果:内异症组EMAb阳性率为63.30%,对照组为10%,两组差异有显著性(P<0.05)。内异症各期及子宫腺肌病间EMAb阳性率差异无显著性(P>0.05)。内异症组血清CA125水平平均为70.70±16.62U/ml,对照组为15.38±5.32U/ml,两组差异有显著性。如以CA125≥35U/ml为阳性界值,则内异症组阳性率为80.23%,对照组为6.66%。单独测定EMAb诊断内异症的敏感性为63.30%,特异性为90%;单独测定CA125诊断内异症的敏感性为80.23%、特异性为93.33%。如以两者均阳性为诊断标准,则敏感性为57.80%,特异性为100%;如以其中之一阳性为诊断标准,则敏感性为91.74%,特异性为83.33%。结论:测定内异症患者血清中EMAb及CA125水平对内异症有较好的辅助诊断价值,联合测定EMAb及? 相似文献
28.
尖锐湿疣患者人乳头瘤病毒的基因分型 总被引:2,自引:0,他引:2
目的 探索尖锐湿疣患者人乳头瘤病毒的基因分型。方法 PCR方法检测HPV6/11型、HPV16/18型DNA。结果 检测尖锐湿疣患者100例,对其中35例进行组织活检,阳性检出率为91.4%(32/35),阳性检出中,HPV6/11型26例(81.2%),HPV16/18型3例(9.4%),HPV6/11 HPV16/18型3例(9.4%);对其中65例进行宫颈抹片检测,阳性检出率为92.3%(60/65),阳性检出中,HPV6/11型41例(68.3%),HPV16/18型12例(20.0%),HPV6/11 HPV16/18型7例(11.7%)。结论 尖锐湿疣患者人乳头瘤病毒感染以HPV6/11型为主,HPV16/18型在宫颈处感染率高于其它处组织。 相似文献
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