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排序方式: 共有4493条查询结果,搜索用时 31 毫秒
91.
Duration of disease does not equally influence all aspects of quality of life in Parkinson’s disease
Health related quality of life (HRQoL) is negatively impacted in patients suffering from Parkinson’s disease (PD). For the specific components that comprise HRQoL, the relationship between clinical variables, such as disease duration, is not fully characterized. In this cross-sectional study (n = 302), self-reported HRQoL on the Parkinson’s Disease Questionnaire (PDQ-39) was evaluated as a global construct as well as individual subscale scores. HRQoL was compared in three groups: those within 5 years of diagnosis, those within 6–10 years of diagnosis, and those greater than 11 years since diagnosis. Non-parametric analyses revealed lower HRQoL with increasing disease duration when assessed as a global construct. However, when subscales were evaluated, difficulties with bodily discomfort and cognitive complaints were comparable in individuals in the 1–5 years and 6–10 year duration groups. Exploratory regression analyses suggested disease duration does explain unique variance in some subscales, even after controlling for Hoehn and Yahr stage and neuropsychiatric features. Our findings show that HRQoL domains in PD patients are affected differentially across the duration of the disease. Clinicians and researchers may need to tailor interventions intended to improve HRQoL at different domains as the disease progresses. 相似文献
92.
《Parkinsonism & related disorders》2014,20(12):1382-1387
BackgroundSwallowing disturbances are an important issue in Parkinson's disease (PD) as several studies have shown that they are associated with increased risk of aspiration pneumonia and mortality. Information about factors related to swallowing disturbances, such as disease duration, age at assessment and concomitant dementia, is limited and would be useful for their management.MethodsAll consecutive PD out-patients evaluated at a movement disorders clinic over a 7-year period (2007–2014), were included in the present retrospective study. Presence of symptomatic swallowing disturbances was assessed using the specific item of the Non Motor Symptom Questionnaire.ResultsIn the whole PD population (N = 6462), prevalence of symptomatic swallowing disturbances was 11.7% (95%CI, 10.9–12.5). Multivariable logistic regression analysis (adjusted for education) disclosed a significant interaction between disease duration and gender (P = 0.009). In both gender strata, swallowing disturbances were significantly associated with longer disease duration and dementia (P < 0.001 for all). A significant effect for age at assessment was also found in male patients. In non-demented patients, swallowing disturbances were associated with male gender, age and disease duration (P < 0.02 for all). In demented patients an association was found only with male gender (P = 0.018) and disease duration (P < 0.001).ConclusionsGender, age, disease duration and dementia all seem to contribute to the occurrence of swallowing disturbances independently. However, the role played by these factors in sub-groups of patients stratified by gender and concomitant dementia suggests that swallowing disturbances are likely related to different neuro-degenerative patterns within the brain. The underlying mechanisms deserve further investigation. 相似文献
93.
《Clinical linguistics & phonetics》2013,27(11):781-793
This study had two objectives. The first was to analyse the impact of Parkinson's disease (PD) on the duration of CV syllables and their components in different positions within phrases in French; the second was to examine the distribution of final lengthening (FL) on syllable sub-components. Two main tendencies emerged: (1) PD patients produced normal FL, and (2) FL influenced vowels more than consonants. These findings suggest that PD speakers had no difficulty with FL and that there is a progressive lengthening across the sub-constituents of the final syllable. More fundamentally, these results indicate that the syntactic function of prosody is intact in PD patients, at least during the early and mild stages of the disease. 相似文献
94.
95.
目的通过比较右室间隔部起搏和右室心尖部起搏电极参数和心功能的变化趋势,选择更为有利的起搏方式。方法选取心尖部起搏21例和间隔部起搏21例,术时、12个月、24个月随诊,分别作心脏彩色多普勒超声检查,记录左室舒张末期内径(LVEDD)、左室射血分数(LVEF)、起搏心电图测量Ⅱ导联QRS波时限、抽血查氨基末端脑钠肽前体(NT-proBNP)、起搏器程控仪记录阈值、阻抗、R波感知进行比较。结果间隔部组比心尖部组QRS时限和电极阻抗小,随起搏时间延长QRS时限、NT-proBNP、LVEDD增加、LVEF(%)下降,心尖部组表现较为明显。结论间隔部起搏QRS波较窄,LVEF(%)下降缓慢、LVEDD(mm)和NT-proBNP(pg/m1)升高缓慢,与心尖部起搏比较,心室同步性好、可延缓心功能减退,是右室起搏较好的选择部位。 相似文献
96.
《Early child development and care》2012,182(5):513-525
The goal of this study was to identify parenting behaviors practiced by a self‐selected group of North American parents who identify themselves as attachment parents. This type of parenting is based on behaviors that are focused on infant needs and demands perhaps more strongly than are traditional mainstream western parenting practices. However, little is known about the demographics of the parents or the actual parameters of their behaviors. In order to further investigate these behaviors, a self‐report questionnaire was developed for use in the study. This questionnaire was included, without return postage, in an international parenting magazine, Compleat Mother. A sample of 275 mothers returned the instrument. Respondents were predominantly married, college educated and White. The respondents reported that of their infants the majority were exclusively breastfed on the infant’s cue and for an extended period of time, coslept and were held or nursed during the transition to sleep. These practices are discussed through a cross‐cultural perspective. 相似文献
97.
Diane Thulier Judith Mercer 《Journal of obstetric, gynecologic, and neonatal nursing : JOGNN / NAACOG》2009,38(3):259-268
Objective: To identify the variables associated with breastfeeding duration.
Data Sources: The health science reference databases of CINAHL, PubMed, and the Cochrane Database of Systematic Reviews.
Study Selection: Meta-analyses, Cochrane reviews, literature reviews, and quantitative and qualitative studies published in English from 1998 through 2008.
Data Extraction: Data included all variables, both positive and negative, that were found to influence the outcome of breastfeeding duration.
Data Synthesis: Demographic factors that influence breastfeeding duration are race, age, marital status, education, socioeconomics, and Special Supplemental Nutrition Program for Women, Infants, and Children status. Biological variables consisted of insufficient milk supply, infant health problems, maternal obesity, and the physical challenges of breastfeeding, maternal smoking, parity, and method of delivery. Social variables included paid work, family support, and professional support. Maternal intention, interest, and confidence in breastfeeding were psychological variables.
Conclusion: Human lactation is a complex phenomena and the duration of breastfeeding is influenced by many demographic, physical, social, and psychological variables. 相似文献
Data Sources: The health science reference databases of CINAHL, PubMed, and the Cochrane Database of Systematic Reviews.
Study Selection: Meta-analyses, Cochrane reviews, literature reviews, and quantitative and qualitative studies published in English from 1998 through 2008.
Data Extraction: Data included all variables, both positive and negative, that were found to influence the outcome of breastfeeding duration.
Data Synthesis: Demographic factors that influence breastfeeding duration are race, age, marital status, education, socioeconomics, and Special Supplemental Nutrition Program for Women, Infants, and Children status. Biological variables consisted of insufficient milk supply, infant health problems, maternal obesity, and the physical challenges of breastfeeding, maternal smoking, parity, and method of delivery. Social variables included paid work, family support, and professional support. Maternal intention, interest, and confidence in breastfeeding were psychological variables.
Conclusion: Human lactation is a complex phenomena and the duration of breastfeeding is influenced by many demographic, physical, social, and psychological variables. 相似文献
98.
99.
Craig I. Coleman Alexander G.G. Turpie Thomas J. Bunz Jan Beyer-Westendorf William L. Baker 《The American journal of medicine》2019,132(4):498-504
Background
We sought to evaluate the real-world effectiveness and safety of prolonged anticoagulation with rivaroxaban following a provoked venous thromboembolism.Methods
Using US MarketScan claims from November 2012 to March 2017, we identified adults with ≥1 primary hospitalization or emergency department diagnosis code for venous thromboembolism, a provoking (major or minor, persistent or transient) risk factor, at least 3 months of continuous rivaroxaban treatment, and ≥12 months of continuous insurance benefits prior to their qualifying venous thromboembolism. Patients were categorized as either continuing rivaroxaban or discontinuing anticoagulation (no anticoagulation or nonaspirin antiplatelet agents but may have received aspirin) after the initial 3 months of rivaroxaban treatment (index date). Differences in baseline covariates between cohorts were adjusted for using inverse probability-of-treatment weights based on propensity scores (absolute standardized differences <0.1 achieved for all covariates after adjustment). Twelve month incidences of recurrent venous thromboembolism or major bleeding were compared between cohorts using Cox regression (according to an intention-to-treat methodology) and reported as hazard ratios (HRs) with 95% confidence intervals (CIs).Results
Among patients experiencing a provoked venous thromboembolism and treated with rivaroxaban for the first 3 months (N=4,990), continued rivaroxaban use beyond 3 months (median [25%, 75% range duration of additional rivaroxaban use?=?3 [2, 5] months) was associated with a 44% (95% CI of 9%-66%) lower hazard of recurrent venous thromboembolism without altering major bleeding risk [HR of 0.87, 95% CI of 0.51-1.49] versus anticoagulation discontinuation (with or without aspirin use).Conclusions
Our study suggests continuing rivaroxaban after the initial 3 month period was associated with a decreased risk of recurrent venous thromboembolism. The observed reduction in recurrent venous thromboembolism with prolonged rivaroxaban use was not associated with a significant change in major bleeding risk. 相似文献100.
Two definitions of the “disease duration” of ankylosing spondylitis (AS) have been used in the literature: (1) duration since
first symptoms connected with AS and (2) duration since diagnosis of AS. To investigate how useful these definitions are for
research, we reinvestigated the data of four surveys completed by patients with AS in the years since 1996. We found that
the majority of the patients remembered the age at first symptoms with an accuracy of ≤1 year, and that the difference between
both definitions (the delay in diagnosis) was between 9.8 and 10.4 years on average, with extreme values of more than 30 years
being not very seldom. Because the error made using the duration since diagnosis as “disease duration” is much larger than
the inaccuracy taken into account using the duration since first symptoms, only the duration since first symptoms connected
with AS should be used as definition for the term “disease duration” of AS. 相似文献