Maintenance of Remission With Tofacitinib Therapy in Patients With Ulcerative Colitis

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Efficacy and safety of rupatadine in Japanese adult and adolescent patients with chronic spontaneous urticaria: A double-blind,randomized, multicenter,placebo-controlled clinical trial

Background

Rupatadine, a novel nonsedating second-generation H1-antihistamine with antiplatelet-activating factor activity, has been used in the treatment of allergic rhinitis and urticaria in European countries since 2003. However, its efficacy and safety in Japanese patients with chronic spontaneous urticaria (CSU) are unknown.

Characterisation of patients with primary biliary cirrhosis responding to long term ursodeoxycholic acid treatment

BACKGROUND: In some patients with primary biliary cirrhosis, ursodeoxycholic acid causes full biochemical normalisation of laboratory data; in others, indexes improve but do not become normal. AIMS: To characterise complete and incomplete responders. METHODS: Seventy patients with primary biliary cirrhosis were treated with ursodeoxycholic acid 10-15 mg/kg/day and followed up for 6-13 years. RESULTS: In 23 patients (33%) with mainly stage I or II disease, cholestasis indexes and aminotransferases normalised within 1-5 years, except for antimitochondrial antibodies. Histological findings improved. Indexes were not normalised in 47 patients (67%) although the improvement of their biochemical functions parallelled the trend in the first group. In these incomplete responders histological findings improved to a lesser extent. The only difference between the two groups before treatment was higher levels of alkaline phosphatase and gamma glutamyl transpeptidase in the incomplete responders. At onset of treatment the discriminant value separating responders from incomplete responders was 660 U/l for alkaline phosphatase and 131 U/l for gamma glutamyl transpeptidase. One year later it was 239 and 27 U/l (overall predictive value for responders 92%, for incomplete responders 81%). There were no differences between the two groups concerning immune status, antimitochondrial antibody subtypes, liver histology, or any other data. HLA-B39, DRB1*08, DQB1*04 dominated in both groups. CONCLUSIONS: In patients with mainly early stages of primary biliary cirrhosis, higher values of alkaline phosphatase and gamma glutamyl transpeptidase are the only biochemical indexes which allow discrimination between patients who will completely or incompletely respond to ursodeoxycholic acid treatment.     

不同管理模式对住院精神病患者病情与负性行为的影响

目的探讨不同管理模式对住院精神病患者的消极、冲动、外逸等负性行为及疾病康复的影响,以便为患者采用最佳的管理模式。方法采用随机抽样的方法,将本院2003年1月起入住七病区的前104例患者为观察组,入住二、四(女)病区,三、五(男)病区的前106例为对照组,比较两组患者入院初与出院前1周的简明精神病评定量表(BPRS),总体评定量表(GAS)、社会内向量表(SI)得分;入院初消极、冲动、外逸意向数及住院期间消极、冲动、外逸发生数。结果入院初BPRS、GAS、SI得分与消极、冲动、外逸意向数,两组无差别(P>0.05),出院前1周BPRS、GAS、SI得分两组有显著性差别(P<0.01),观察组明显优于对照组,消极、冲动、外逸发生数观察组明显低于对照组(P<0.01)。结论对住院精神患者实施全开放管理明显优于半封闭管理。     

Characterization of a monoclonal anti-Bw4 antibody (Tü109): Evidence for similar epitopes on the Bw4 and Bw6 antigens

The production and serologic, as well as immunochemical properties of a cytotoxic murine IgG monoclonal antibody (Tü109) that precipitates HLA-class I molecules, are described. In the microcytotoxicity assay Tü109 supernatant was demonstrated on a panel of 424 HLA-ABC, -DR, -DQ, -MT typed normal Caucasian blood donors to define an epitope on HLA-B locus molecules in great association with the supertypic specificity Bw4. Reactivity of supernatant showed MHC linked inheritance of the Tü109 determinant and discriminated the HLA-Bw4/Bw6 associated HLA-B locus split antigens. Weak or lack of binding on lymphocytes from some HLA-Bw4 heterozygous individuals, particularly typing for HLA-Bw44, appeared to be due to qualitative and/or quantitative variations of HLA-B locus molecules on the cell surface. With Tü109 ascites fluid, however, extra-reactivity on all HLA-Bw6⁺ cells was demonstrated. Preferential binding of supernatant to HLA-Bw4, but reactivity of ascites fluid with HLA-Bw6⁺ molecules in addition, was furthermore confirmed by IEF analysis of antigens immunoprecipitated with Tü109 from cell lysates. Thus the antibody may help to analyze the evolutionary relationship of the diallelic specificities Bw4 and Bw6.     

米索前列醇在产程中的临床应用研究

目的研究米索前列醇（米索）在产程中的应用效果。方法对足月妊娠符合引产指征者行米索前列醇或常规催产素引产，对潜伏期延长和活跃期停止的产妇行米索前列醇或催产素加强宫缩（简称催产）。统计本站分娩272例孕产妇随机分成两组，即米索组172例（引产104例，催产68例），催产素组100例（引产60例，催产40例）。米索前列醇25^ug（1／8片）q4h舌下含化，催产素0．3u＋5％GNS500ml，静脉滴注。结果米索组引产成功率73．08％，有效23．07％，无效3．85％，催产成功率73．57％，有效19．12％，无效7．35％。催产素组引产成功率为46．67％，有效35％，无效18．33％。催产成功率70％，有效22．5％，无效7．5％。剖宫产率：烛索组20．35％，催产素组30％。结论米索前列醇用于足月妊娠引产和宫缩乏力强加宫缩（催产），此方法经济、方便、完全、稳定、可靠，大大提高了病人对药物的可接受性，临床上可推广应用。     

IQ200全自动尿沉渣分析仪在筛查尿路感染中的意义

目的 探讨iQ200全自动尿沉渣分析仪在尿路感染中的筛选意义.方法 以50例健康体检者为对照,收集240例怀疑尿路感染的门诊患者的两份尿液标本.一份用IQ200尿沉渣分析仪检测细菌（BACT）,根据检测结果分为BACT阳性组与BACT阴性组来进行细菌培养,以细菌培养结果作为标准,比较iQ200对尿路感染的筛查意义.结果 BACT阳性组的细菌培养结果阳性率最高,iQ200对革兰氏阴性菌与革兰氏阳性菌与真菌的诊断效能：灵敏度为96.6%、86.6%、94.5%,特异度为94.4%、58.1%、87.6%,准确度为95.0%、61.6%、88.7,iQ200对革兰氏阴性菌与真菌有较佳的筛选价值,对革兰氏阳性菌的特异性较低.结论 IQ200尿沉渣分析仅对尿路感染具有一定的筛选作用,但不能完全代替细菌培养.     

日立7170和贝克曼DXC800全自动生化分析仪天门冬氨酸氨基转移酶检测结果比对评价

目的：探讨日立7170全自动生化分析仪（简称7170分析仪）和贝克曼 DXC800全自动生化分析仪（检测DXC800分析仪）检测天门冬氨酸氨基转移酶（AST）结果的可比性。方法以7170分析仪作为参考仪器, DXC800分析仪作为实验仪器,按照美国临床和实验室标准化协会（CLSI）EP9-A2文件的要求设计比对方案,以采集自临床患者的空腹新鲜血清标本为待测标本,以美国临床实验室修正法规1988（CLIA′88）允许总误差的1/2作为标准,对两台仪器检测结果间偏差进行评估。结果两台仪器 AST检测结果有较好的相关性,结果间的偏差在临床可接受范围内。结论7170分析仪和DXC800分析仪检测 AST的结果具有可比性,且一致性较好。     

低分子肝素治疗孕足月病理性高凝状态的效果评价

目的探讨低分子肝素治疗孕足月病理性高凝状态的有效性和安全性。方法选取本院分娩D-聚体高于参考值的孕产妇160例并分为治疗组和对照组,每组80例。治疗组予低分子肝素钙4100U皮下注射,1次／d,7d为一个疗程;对照组不予抗凝治疗。同时监测7d低分子肝素应用后、术后／产后2d的凝血功能、D-二聚体值及血常规、妊娠及围产儿结局。结果低分子肝素能明显降低血液高凝状态,能使围生期病理性高凝状态转变为生理性高凝状态,从而降低vTE及DIC的发病率。结论低分子肝素钙能安全有效地预防并治疗孕妇病理性高凝状态,值得临床推广应用。