支气管动脉灌注化疗联合直线加速器放射治疗Ⅲa期非小细胞肺癌

目的　研究支气管动脉灌注化疗联合直线加速器放射治疗Ⅲa期非小细胞肺癌 (NSCLC)的可行性及临床价值。方法　 76例NSCLC患者随机分成A、B 2组 ,A组先行 2次支气管动脉灌注化疗 (BAI) ,第 2次BAI 1～ 2周后再行直线加速器放射治疗 (RT) ;B组单纯行 2次BAI (对照组 )。结果　临床疗效 ,A组 (BAI RT)和B组 (BAI)分别为 89.47%和 60 .5 3% (Ρ <0 .0 1) ;1、3年生存率 ,A、B组分别为 81.5 8%、5 0 .0 0 %和 60 .5 3%、2 1.0 5 % ( 0 .0 1<Ρ <0 .0 5 )。结论　支气管动脉灌注化疗联合直线加速器放射治疗Ⅲa期非小细胞肺癌的临床疗效和患者 1、3年生存率均显著提高     

Liver microsomal cytochrome: P-450p and P-450h activity and blood corticosteroid levels of experimental animals exposed to physical factors

Laboratory of Experimental Therapy, Institute of Balneology, Ministry of Health of the Ukraine, Odessa. Department of Cell Physiology and Pathology, Institute of Clinical and Experimental Medicine, Siberian Branch, Academy of Medical Sciences, Novosibirsk. (Presented by Academician of the Academy of Medical Sciences V. Ya. Kaznacheev.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 113, No. 5, pp. 498–500, May, 1992.     

不同时辰刺激大鼠的交叉上核对血浆中皮质酮含量的影响

应用拉丁方设计，在不同体重组的大鼠，于不同时辰，对交叉上核采取不同强度的刺激，用放射免疫法测定外周血中皮质酮的含量。其结果显示：各体重组间无显著性差异，不同时辰血浆皮质酮的平均含量各组呈现基本相同的节律性变化，无论何时辰刺激交叉上核使之兴奋，均可显著提高血浆皮质酮的含量。完全损毁交叉上核后７２小时血浆皮质酮含量和正常对照组无显著性差异，且其节律性也没有出现明显变化。     

Ethics and Society: Filiation in assisted reproduction: potential conflicts and legal implications

Filiation, or a person's parentage, is one of the major componentsof someone's identity, often with important implications forthat person's welfare in social and personal terms. Fertilityspecialists are enjoined to consider the welfare of the child,and this is a legal requirement in assisted reproduction techniquesin the UK. This paper is in three parts, discussing some ofthe potential problems regarding filiation of the prospectivechild born of assisted reproduction techniques, in relationto the use of gametes and embryos. The first two parts concentrateon the status of children born as a result of treatment givenposthumously, and on filiation problems associated with donationof gametes or embryos, and surrogacy. The third part comparesBritish and French legislation with special regard to the welfareof the child, as well as underlining the common trends and principlesenunciated in both legislations. This is particularly appropriateat a time when the European Society for Human Reproduction andEmbryology is about to issue ethical guidelines in assistedreproduction, and when both the Council of Europe and the EuropeanCommission have commissioned studies on the implications ofthe assisted techniques, including those concerning status ofthe potential children.     

女性乳头湿疹样癌与乳腺癌浸润乳头之间区别的探讨

本文对１９８０～１９８２年间．天津肿瘤医院收治可手术原发女性乳腺癌７１５侧重新复习。根据镜下在乳头皮肤见到ｐａｇｅｔ细胞以及癌直接浸润（或累及）乳头，确定乳头湿疹样癌２０例，乳腺癌浸润乳头６９例。比较两组在临床表现、病理形态和预后的差异。结果发现，乳头湿疹样癌的临床表现以乳头糜烂，结痂为主，而乳腺癌浸润乳头则以乳头凹陷、皮肤粘连、桔皮样变和乳头抬高为主；镜下形态，乳头湿疹样癌主要是在乳头表皮内见到Ｐａｇｅｔ细胞，晚期亦可浸及乳头基质。乳腺癌浸润乳头主要特点是癌细胞浸润乳腺导管，管壁可完整或被浸破，癌亦可直接浸润乳头基质，绝大多数皮肤正常，直接累及皮肤少见，均无Ｐａｇｅｔ细胞。通过本文研究，作者认为乳头湿疹样癌为乳腺癌的独立类型，其在临床表现、病理形态及预后等方面，均与乳腺癌浸润乳头有显著区别。     

消毒剂敌菲特的研究

经全面考察研究,敌菲特缓释消毒灭菌剂具有良好的消毒灭菌效果,对细菌繁殖体、病毒和细菌芽孢均可完全灭活;即使在—20℃低温条件下,对枯黑变种芽孢仍具很好的杀灭效果。此外,该消毒剂基本克服了氯制剂对金属腐蚀性的缺陷;原药性能基本稳定。     

食管癌切除食管胃颈部吻合术后吻合口并发症分析

我院自１９７９～１９９１年共行食管癌切除，食管胃颈部吻合术１０８７例。术后吻合口并发症９２例，发生率８．５％，其中吻合口瘘５．６％、吻合口狭窄２．７％、吻合口颈动脉瘘０．２％。讨论了颈部吻合口并发症的原因和预防措施。     

Lifetime and six-month prevalence of mental disorders in the Munich follow-up study

Summary The Lifetime and 6 month DSM-III prevalence rates of mental disorders from an adult general population sample of former West Germany are reported. The most frequent mental disorders (lifetime) from the Munich Follow-up Study were anxiety disorders (13.87%), followed by substance (13.51%) and affective (12.90%) disorders. Within anxiety disorders, simple and social phobia (8.01%) were the most common, followed by agoraphobia (5.47%) and panic disorder (2.39%). Females had about twice the rates of males for affective (18.68% versus 6.42%), anxiety (18.13% versus 9.07%), and somatization disorders (1.60% versus 0.00%); males had about three times the rates of substance disorders (21.23% versus 6.11%) of females. Being widowed and separated/divorced was associated with high rates of major depression. Most disordered subjects had at least two diagnoses (69%). The most frequent comorbidity pattern was anxietyand affective disorders. Simple and social phobia began mostly in childhood or early adolescence, whereas agoraphobia and panic disorder had a later average age of onset. The majority of the cases with both anxiety and depression had depression clearly after the occurrence of anxiety. The DIS-DSM-III findings of our study have been compared with both ICD-9 diagnoses assigned by clinicians independently as well as other epidemiological studies conducted with a comparable methodology.     

海南省钩端螺旋体病地理流行病学研究 Ⅰ.自然地理、动物地理区划和流行概况

本文简介海南岛的自然地理、啮齿动物地理区划和社会经济（包括人口数、性别年龄分布、人工植被、耕作习惯等）与钩端螺旋体病发生或流行有关的自然因素．扼要报告自1958─1991年以来各年度该病的发病率与病死率，比较了50─90年代总的发病态势是低→高→低，并略作了分析。