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991.
Flavia Coroian Claire Jourdan Karima Bakhti Claire Palayer Audrey Jaussent Marie-Christine Picot Denis Mottet Marc Julia Huey-Yune Bonnin Isabelle Laffont 《Archives of physical medicine and rehabilitation》2018,99(2):321-328
Objective
To assess the benefit of isokinetic strengthening of the upper limb (UL) in patients with chronic stroke as compared to passive mobilization.Design
Randomized blinded assessor controlled trial.Setting
Physical Medicine and Rehabilitation departments of 2 university hospitals.Participants
Patients (N=20) with incomplete hemiplegia (16 men; mean age, 64y; median time since stroke, 32mo).Interventions
A 6-week comprehensive rehabilitation program, 3d/wk, 3 sessions/d. In addition, a 45-minute session per day was performed using an isokinetic dynamometer, with either isokinetic strengthening of elbow and wrist flexors/extensors (isokinetic strengthening group) or passive joint mobilization (control group).Main Outcome Measures
The primary endpoint was the increase in Upper Limb Fugl-Meyer Assessment (UL-FMA) score at day 45 (t1). Secondary endpoints were increases in UL-FMA scores, Box and Block Test scores, muscle strength, spasticity, and Barthel Index at t1, t2 (3mo), and t3 (6mo).Results
Recruitment was stopped early because of excessive fatigue in the isokinetic strengthening group. The increase in UL-FMA score at t1 was 3.5±4.4 in the isokinetic strengthening group versus 6.0±4.5 in the control group (P=.2). Gains in distal UL-FMA scores were larger (3.1±2.8) in the control group versus 0.6±2.5 in the isokinetic strengthening group (P=.05). No significant group difference was observed in secondary endpoints. Mixed models confirmed those results. Regarding the whole sample, gains from baseline were significant for the UL-FMA at t1 (+4.8; P<.001), t2, and t3 and for the Box and Block Test at t1 (+3; P=.013) and t2.Conclusions
In a comprehensive rehabilitation program, isokinetic strengthening did not show superiority to passive mobilization for UL rehabilitation. Findings also suggest a sustained benefit in impairments and function of late UL rehabilitation programs for patients with stroke. 相似文献992.
Kara K. Patterson Jennifer S. Wong Svetlana Knorr Jessica A. Grahn 《Archives of physical medicine and rehabilitation》2018,99(5):945-951
Objectives
To assess rhythm abilities, to describe their relation to clinical presentation, and to determine if rhythm production independently contributes to temporal gait asymmetry (TGA) poststroke.Design
Cross-sectional.Setting
Large urban rehabilitation hospital and university.Participants
Individuals (N=60) with subacute and chronic stroke (n=39) and data for healthy adults extracted from a preexisting database (n=21).Interventions
Not applicable.Main Outcome Measures
Stroke group: National Institutes of Health Stroke Scale (NIHSS), Chedoke-McMaster Stroke Assessment (CMSA) leg and foot scales, Montreal Cognitive Assessment (MoCA), rhythm perception and production (Beat Alignment Test [BAT]), and spatiotemporal gait parameters were assessed. TGA was quantified with the swing time symmetry ratio. Healthy group: age and beat perception scores assessed by the BAT. Rhythm perception of the stroke group and healthy adults was compared with analysis of variance. Spearman correlations quantified the relation between rhythm perception and production abilities and clinical measures. Multiple linear regression assessed the contribution of rhythm production along with motor impairment and time poststroke to TGA.Results
Rhythm perception in the stroke group was worse than healthy adults (F1,56=17.5, P=.0001) Within the stroke group, rhythm perception was significantly correlated with CMSA leg (Spearman ρ=.33, P=.04), and foot (Spearman ρ=.49, P=.002) scores but not NIHSS or MoCA scores. The model for TGA was significant (F3,35=12.8, P<.0001) with CMSA leg scores, time poststroke, and asynchrony of rhythm production explaining 52% of the variance.Conclusions
Rhythm perception is impaired after stroke, and temporal gait asymmetry relates to impairments in producing rhythmic movement. These results may have implications for the use of auditory rhythmic stimuli to cue motor responses poststroke. Future work will explore brain responses to rhythm processing poststroke. 相似文献993.
994.
R. Lee Kirby Paula W. Rushton Francois Routhier Louise Demers Laura Titus Jan Miller-Polgar Cher Smith Mike McAllister Chris Theriault Kara Matheson Kim Parker Bonita Sawatzky Delphine Labbé William C. Miller 《Archives of physical medicine and rehabilitation》2018,99(7):1295-1302.e9
Objective
To test the hypothesis that caregivers enhance the wheelchair skills capacity and confidence of the power wheelchair users to whom they provide assistance, and to describe the nature of that assistance.Design
Multicenter cross-sectional study.Setting
Rehabilitation centers and communities.Participants
Participants (N=152) included caregivers (n=76) and wheelchair users (n=76).Interventions
None.Main Outcome Measures
Version 4.3 of the Wheelchair Skills Test (WST) and the Wheelchair Skills Test-Questionnaire (WST-Q). For each of the 30 individual skills, we recorded data about the wheelchair user alone and in combination (blended) with the caregiver.Results
The mean total WST capacity scores ± SD for the wheelchair users alone and blended were 78.1%±9.3% and 92.4%±6.1%, respectively, with a mean difference of 14.3%±8.7% (P<.0001). The mean WST-Q capacity scores ± SD were 77.0%±10.6% and 93.2%±6.4%, respectively, with a mean difference of 16.3%±9.8% (P<.0001). The mean WST-Q confidence scores ± SD were 75.5%±12.7% and 92.8%±6.8%, respectively, with a mean difference of 17.5%±11.7% (P<.0001). The mean differences corresponded to relative improvements of 18.3%, 21.0%, and 22.9%, respectively. The nature and benefits of the caregivers' assistance could be summarized in 7 themes (eg, caregiver provides verbal support [cueing, coaching, reporting about the environment]).Conclusions
Caregivers significantly enhance the wheelchair skills capacity and confidence of the power wheelchair users to whom they provide assistance, and they do so in a variety of ways. These findings have significance for wheelchair skills assessment and training. 相似文献995.
体模、试件是超声影像设备性能检测和质量保证的关键技术手段。本文描述其国产化、标准化的发展历程和现状,并为此阐释了若干重要定义,归纳了表征超声影像设备技术性能的主要参数。 相似文献
996.
Muriel Guyard‐Nicodème Eloise Gerault Marion Platteel Olivier Peschard Wilfried Veron Philippe Mondon Svinareff Pascal Marc G. J. Feuilloley 《Journal of applied toxicology : JAT》2015,35(1):48-58
Most animal experiments on cosmetics safety are prohibited and since March 2013, this obligation includes sensitization tests. However, until now there has been no validated alternative in vitro method. In this work, 400 compounds used in the cosmetic industry were selected to cover the greatest diversity of structures, biological activities and sensitizing potential. These molecules were submitted to a series of tests aimed at reproducing essential steps in sensitization and to distinguish between sensitization and irritations, i.e., transcutaneous permeation (factor A), haptenation (factor B), sensitization cytokines production (factor C) and acute toxicity (factor D). The transcutaneous diffusion was measured on human skin explants using Franz cells. Haptenation was tested in solution on human serum albumin. Sensitization cytokine production was investigated by measurement of interleukin‐18 release by keratinocytes. Acute toxicity was determined using an 3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide75 cell viability test. As only sufficiently stable, soluble and detectable compounds are usable, 33, 72, 68 and 68 molecules were finally tested on factors A, B, C and D, respectively, and 32 were completely screened by the four factors. The individual correlation of the four factors with the reference in vivo tests was limited but the combination of these factors led to a correlation between in vivo and in vitro assays of 81.2% and the safety of the test (risk of false negative) reached 96.8%. The techniques employed are simple and inexpensive and this model of four tests appears as a promising technique to evaluate in vitro the skin sensitization potential of unknown molecules. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
997.
《中国神经再生研究》2016,(12):1932-1939
Low-frequency repetitive transcranial magnetic stimulation(LF-r TMS) to the contralesional hemisphere and intensive occupational therapy(i OT) have been shown to contribute to a significant improvement in upper limb hemiparesis in patients with chronic stroke. However, the effect of the combined intervention program of LF-r TMS and i OT on cognitive function is unknown. We retrospectively investigated whether the combined treatment influence patient's Trail-Making Test part B(TMT-B) performance, which is a group of easy and inexpensive neuropsychological tests that evaluate several cognitive functions. Twenty-five patients received 11 sessions of LF-r TMS to the contralesional hemisphere and 2 sessions of i OT per day over 15 successive days. Patients with right- and left-sided hemiparesis demonstrated significant improvements in upper limb motor function following the combined intervention program. Only patients with right-sided hemiparesis exhibited improved TMT-B performance following the combined intervention program, and there was a significant negative correlation between Fugl-Meyer Assessment scale total score change and TMT-B performance. The results indicate the possibility that LF-r TMS to the contralesional hemisphere combined with i OT improves the upper limb motor function and cognitive function of patients with right-sided hemiparesis. However, further studies are necessary to elucidate the mechanism of improved cognitive function. 相似文献
998.
Rasch analysis of the Pediatric Evaluation of Disability Inventory–computer adaptive test (PEDI‐CAT) item bank for children and young adults with spinal muscular atrophy
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Amy Pasternak PT DPT Allan M. Glanzman PT DPT Jacqueline Montes PT EdD Sally Dunaway PT DPT Rachel Salazar PT DPT Janet Quigley PT Shree Pandya MS PT Susan O'Riley PT DPT Jonathan Greenwood PT DPT Claudia Chiriboga MD MPH Richard Finkel MD Gihan Tennekoon MBBS William B. Martens BA Michael P. McDermott PhD Heather Fournier MAMS Lavanya Madabusi BA Timothy Harrington BS Rosangel E. Cruz MA BS Nicole M. LaMarca DNP MSN Nancy M. Videon RN BSN Darryl C. De Vivo MD the Muscle Study Group the Pediatric Neuromuscular Clinical Research Network for Spinal Muscular Atrophy 《Muscle & nerve》2016,54(6):1097-1107
Introduction: In this study we evaluated the suitability of a caregiver‐reported functional measure, the Pediatric Evaluation of Disability Inventory–Computer Adaptive Test (PEDI‐CAT), for children and young adults with spinal muscular atrophy (SMA). Methods: PEDI‐CAT Mobility and Daily Activities domain item banks were administered to 58 caregivers of children and young adults with SMA. Rasch analysis was used to evaluate test properties across SMA types. Results: Unidimensional content for each domain was confirmed. The PEDI‐CAT was most informative for type III SMA, with ability levels distributed close to 0.0 logits in both domains. It was less informative for types I and II SMA, especially for mobility skills. Item and person abilities were not distributed evenly across all types. Conclusions: The PEDI‐CAT may be used to measure functional performance in SMA, but additional items are needed to identify small changes in function and best represent the abilities of all types of SMA. Muscle Nerve 54 : 1097–1107, 2016 相似文献
999.
目的:建立麝香草酚《中国药典》2015年版微生物限度检查方法。方法:需氧菌总数检查为薄膜过滤法,冲洗量为800ml;霉菌和酵母菌总数检查为薄膜过滤法,冲洗液为p H 7.0无菌氯化钠-蛋白胨缓冲液,冲洗量为800 ml;大肠埃希菌检查、金黄色葡萄球菌、铜绿假单胞菌检查均为薄膜过滤法,冲洗液为p H7.0无菌氯化钠-蛋白胨缓冲液,冲洗量为800 ml。结果:在三次独立平行的试验中,5株试验菌的回收比值0.5~2.0。结论:该方法消除了样品的抑菌性,可用于该品种的微生物限度检查。 相似文献
1000.
Yan Deng Wei Cai Jinyan Li Ying Li Xiaolei Yang Yan Ma Yufeng Yao Lujie Yang Li Shi Mingbo Sun 《Vaccine》2019,37(1):130-136
Inactivated poliomyelitis vaccine made from Sabin strains (sIPV) has been encouraged to introduce in the “Global Polio Eradication & Endgame Strategic Plan” and increasingly used worldwide. Attenuated Sabin strains used in manufacture of oral poliovirus vaccine (OPV) and sIPV may regain full or partial neurovirulence during growth in vaccine recipients and the vaccine manufacturing processes. Ensuring the molecular consistency of sIPV batches and that no mutation accumulates beyond the level present in past batches are important for quality control of vaccine manufacture process. Direct deep-sequencing allows the construction of a library of virus RNA and the detection of genetic mutations throughout the viral genome. In the present study, direct deep-sequencing was conducted to detect molecular mutations in virus passages, multiple sIPV monovalent lots, and virus monovalent lots from different polio type III strains. The results indicated that direct deep-sequencing can be used to identify and quantify small amounts of mutant viruses in vaccine preparations, trace the source of a specific virus seed, and monitor the batch-to-batch consistency of vaccines, suggesting that this technique could be suitable for the quality control and consistency monitoring of sIPV production. 相似文献