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91.
Pekka Honkavaara Ilmari Pyykkö Eeva-Marja Rutanen 《Journal canadien d'anesthésie》1996,43(11):1108-1114
Purpose
To assess the effect of the menstrual cycle on post-operative retching and vomiting (R& V) after middle ear surgery, and the efficacy of prophylaxis against R& V in female patients with transdermal scopolamine during either general or local anaesthesia and with intravenous ondansetron during general anaesthesia. 相似文献92.
Jan Abrahamsen Ove A. Nedergaard 《Naunyn-Schmiedeberg's archives of pharmacology》1991,343(2):161-165
Summary The aim of the present investigation was to examine whether or not presynaptic facilitatory -adrenoceptors are detectable on the postganglionic nerves in the rabbit isolated ear artery. Strips of rabbit central ear artery were incubated with 3H-noradrenaline (10–7 mol/l; 30 min or 10–6 mol/l; 60 min). Subsequently, they were washed repeatedly with physiological salt solution. The strips were subjected to electrical-field stimulation (S1–S8) and the resultant 3H-overflow was determined.When the ear artery was stimulated with 150 pulses (0.5 ms; 3 Hz; 225 mA), isoprenaline (10–9–10–6 mol/l) either alone or in the presence of either rauwolscine (10–6 mol/l) or phentolamine (10–6 mol/l) did not alter the stimulation-evoked 3H-overflow. This was also the case in the presence of rauwolscine (10–6 mol/l) plus either the selective phosphodiesterase inhibitor ICI 63 197 (3 × 10–5 mol/l) or forskolin (10–6 mol/l). When the ear artery was stimulated with 300 pulses (1 ms; 5 Hz; 225 mA), isoprenaline had no effect on the stimulation-evoked 3H-overflow. This was also the case when phentolamine (10–6 mol/l) was present. Propranolol (10–7–10–5 mol/l) did not alter the stimulation-evoked 3H-overflow. In some experiments, the stimulation current was reduced to 175 mA in order to obtain similar reference release (S3) values despite the presence of rauwolscine (150 pulses; 0.5 ms; 3 Hz). Even then, isoprenaline (10–9–10–6 mol/l) did not change stimulation-evoked 3H-overflow. The results suggest that postganglionic sympathetic nerves in rabbit central ear artery do not possess presynaptic facilitatory -adrenoceptors.
Send offprint requests to J. Abrahamsen at the above address 相似文献
93.
Otological trauma resulting from the Soho Nail Bomb in London, April 1999 We report the otological effects of the April 1999 Soho Nail Bomb on 17 patients. Twenty‐one (62%) tympanic membranes were perforated (pars tensa only); 78% closed spontaneously within 6 months. The mean size of the perforation in the tympanic membrane nearer to the blast was significantly larger than the opposite side [33% ± 8.3 (mean ± SD) and 13% ± 4.1 respectively; P = 0.02]. All patients reported hearing losses that were mixed conductive and sensorineural but mainly high‐frequency sensorineural (4, 6 and 8 kHz, pure tone average 42.3 dB ± 20.5). The sensorineural hearing loss correlated inversely with the distance from the explosion but not with the size of perforation. There was no significant difference in the hearing loss between the ear facing the blast and the opposite ear. Fifteen patients (88%) had temporary tinnitus. No patient complained of any vestibular symptoms. The otological effects of a nail bomb in an enclosed space have not been previously reported. Furthermore, an inverse correlation between hearing loss and distance from the explosion and a significant difference in perforation size facing the blast, compared with the opposite side, are also presented for the first time. The high spontaneous closure rate of perforations and minimal ongoing disability from sensorineural losses favour conservative management in most cases. 相似文献
94.
95.
96.
目的探讨P27蛋白在中耳继发性胆脂瘤上皮中的表达,分析其在胆脂瘤上皮增生调节中的可能作用.方法运用免疫组化En Vision染色法和计算机图像分析法,检测32例胆脂瘤上皮和9例胆脂瘤患者外耳道皮肤中P27蛋白的表达情况.结果 P27表达在胆脂瘤上皮及外耳道皮肤的棘层及颗粒层的细胞核,两种组织P27阳性表达的平均灰度值(±s,下同)分别为(159.698 3±6.991)和(153.138 6±4.702 2),两者差异有显著意义(P<0.01).结论 P27胆脂瘤上皮的低表达有可能是胆脂瘤上皮细胞高度增殖的原因之一. 相似文献
97.
Abstract: This report describes an infant with clinical features consistent with the yellow nail syndrome (YNS), a rare autosomal dominant disorder. He presented at birth with congenital lymphoedema and was referred at 6 months of age for investigation of recurrent cough and wheeze. He had clinical and radiological evidence of bilateral pleural effusions and a pericardial effusion. Following a lung biopsy and pericardial window these were shown to be manifestations of his lymphatic abnormality. He also had persisting middle ear effusions causing conductive deafness requiring hearing aids and secondary immunodeficiency requiring regular immunoglobulin infusions. 相似文献
98.
目的:预测盐酸洛美沙星滴耳剂有效期,用以扩大洛美沙星的临床应用,增加耳科用药。方法:采用紫外分光光度法剧定制剂含重.用经典恒温法和Weibull概率法探讨其德定性。结果:紫外分光光度法测定制剂含量平均回收率为99.80% ,RSD为0.66%。经典恒温法预测本制剂在pH为5~6, 25 ℃ 贮存时有效期为5.16年,Weibull概率法预测其有效期为4.98年。结论:紫外分光光度法测定盐酸洛美沙星滴耳剂快速简便,精密度好,可靠性高。在无阳光直射条件下室温贮存本制剂稳定性好。 相似文献
99.
应用定量组织化学技术分析了CBA和C57BL小鼠耳蜗中糖元代谢的改变,发现18个月和36个月龄CBA小鼠的毛细胞和血管纹中,糖元含量比6周龄CBA正常小鼠明显增高,说明在自然老化CBA小鼠耳蜗中存在糖元储积现象。 相似文献
100.
妊高征患者的胎儿血流速度波形改变特点研究 总被引:1,自引:0,他引:1
目的:研究妊高征患者的胎儿脐动脉、肾动脉以及大脑中动脉的血流速度波形的变化特点。方法:妊高征患者96例,正常妊娠148例,于产前1周内行彩色多普勒超声检测胎儿脐动脉、肾动脉和大脑中动脉的搏动指数(PI),产后随访新生儿预后。结果:随着妊高征的加剧,胎儿脐动脉和肾动脉的PI上升,大脑中动脉的PI则改变不明显。在围产儿预后良好和不良的两组中,随着妊高征的加重,胎儿脐动脉、肾动脉和大脑中动脉的PI均有上升的趋势,但预后不良组的改变比对照组明显。按正常妊娠和轻度、中度、重度妊高征分成4组,胎儿窘迫者脐动脉和肾动脉的PI上升,大脑中动脉的PI下降。结论:妊高征和胎儿窘迫对胎儿脐动脉和肾动脉的血流波形改变有协同作用,对大脑中动脉的改变有阻抗作用 相似文献