全文获取类型
收费全文 | 1995篇 |
免费 | 48篇 |
国内免费 | 22篇 |
专业分类
耳鼻咽喉 | 117篇 |
儿科学 | 235篇 |
妇产科学 | 22篇 |
基础医学 | 181篇 |
口腔科学 | 67篇 |
临床医学 | 93篇 |
内科学 | 390篇 |
皮肤病学 | 45篇 |
神经病学 | 277篇 |
特种医学 | 68篇 |
外科学 | 168篇 |
综合类 | 118篇 |
预防医学 | 74篇 |
眼科学 | 51篇 |
药学 | 109篇 |
中国医学 | 11篇 |
肿瘤学 | 39篇 |
出版年
2023年 | 28篇 |
2022年 | 46篇 |
2021年 | 54篇 |
2020年 | 53篇 |
2019年 | 52篇 |
2018年 | 57篇 |
2017年 | 46篇 |
2016年 | 68篇 |
2015年 | 58篇 |
2014年 | 112篇 |
2013年 | 157篇 |
2012年 | 78篇 |
2011年 | 108篇 |
2010年 | 69篇 |
2009年 | 92篇 |
2008年 | 86篇 |
2007年 | 121篇 |
2006年 | 82篇 |
2005年 | 75篇 |
2004年 | 67篇 |
2003年 | 38篇 |
2002年 | 49篇 |
2001年 | 32篇 |
2000年 | 35篇 |
1999年 | 34篇 |
1998年 | 31篇 |
1997年 | 24篇 |
1996年 | 26篇 |
1995年 | 15篇 |
1994年 | 31篇 |
1993年 | 18篇 |
1992年 | 17篇 |
1991年 | 10篇 |
1990年 | 12篇 |
1989年 | 13篇 |
1988年 | 12篇 |
1987年 | 14篇 |
1986年 | 12篇 |
1985年 | 16篇 |
1984年 | 11篇 |
1983年 | 8篇 |
1982年 | 10篇 |
1981年 | 13篇 |
1979年 | 14篇 |
1978年 | 12篇 |
1977年 | 11篇 |
1976年 | 8篇 |
1974年 | 7篇 |
1973年 | 5篇 |
1969年 | 3篇 |
排序方式: 共有2065条查询结果,搜索用时 15 毫秒
11.
青少年型帕金森病的临床特征 总被引:2,自引:1,他引:1
目的 探讨青少年型帕金森病 (PD)的临床特征。方法 对 2 8例青少年型PD患者的临床资料进行回顾性分析。结果 2 8例中 5例有家族史 ,呈常染色体隐性遗传 (AR JP) ;症状轻、病程长 ,症状常左右不对称 ,腱反射活跃和症状波动较常见 ;头部CT或MRI检查一般正常 ;对多巴制剂反应良好 ,但其所诱发的症状波动出现早。与散发性PD患者相比 ,AR JP患者发病年龄更早 ,为 (2 0 6± 5 6 8)岁 ,病程更长 ,为 (9 5±5 77)年 ,而病情较轻、症状波动和腱反射活跃更多见 ,多巴制剂不良反应更常见。结论 青少年型PD具有独特的临床特征 ,可能是一个独立的疾病实体。AR JP与散发性青少年型PD临床特征不同 ,提示二者可能具有不同的发病机制。 相似文献
12.
Anna Szymańska Elżbieta Korobowicz Wiesław Gołąbek 《European archives of oto-rhino-laryngology》2006,263(7):657-660
Nasopharyngeal angiofibromas occur predominantly in males in their puberty and adolescence; the incidence in other age groups and in women is exceptional. This report describes a case of a 57-year-old woman with nasopharyngeal angiofibroma presenting typical radiological findings in computed tomography, MR imaging and angiography. The tumour was successfully removed and histopathological examination confirmed the diagnosis. In 6 years follow-up the patient is free of symptoms. 相似文献
13.
Hiroshi Wanifuchi Mizuo Kagawa Mikihiko Takeshita Masahiro Izawa Kohichi Kitamura 《Child's nervous system》1988,4(6):361-364
The authors studied 34 patients with juvenile ischemic cerebrovascular disease over a 15-year period. Of the 34 patients, 23 had intracranial occlusions attributed to cerebral thrombosis or embolism and 11 had occlusions resulting from moyamoya disease. Clinicopathological features were evaluated in the 23 cases with ischemic stroke, but not those with moyamoya disease. The cause of the arterial occlusion remained undetermined in 11 patients and was found to be an embolism based on congenital heart disease in 8, on trauma in 3, and on infection in 1. Cerebral angiography was performed in 21 patients. Of these, 17 had stenoses or occlusions corresponding to their symptoms. CT scans were performed in 10 patients; the lesion in question showed no stenosis or occlusion with cerebral angiography. With regard to prognosis, patients with unknown etiology had good outcomes compared with those with congenital heart disease. With respect to acute infantile hemiplegia, 10 patients had convulsive seizures and 4 had a history of an earlier infection. Angiography and CT scans in patients with congenital heart disease demonstrated arterial occlusive sites in the middle cerebral artery region. Three patients had abscesses after their ischemic lesions. 相似文献
14.
Nora Ostrzega 《Diagnostic cytopathology》1993,9(4):457-460
The cytologic findings of juvenile papillomatosis (JP) have been rarely described. The clinical and cytologic findings were suggestive of a fibroadenoma, but due to the presence of 2 cc of clear fluid during the aspiration, fibrocystic change was in the differential diagnosis. Operation and subsequent examination of the mass identified a case of JP (so-called Swiss cheese disease of the breast). Because JP is a marker for breast carcinoma for the patients' families, and the patients may themselves be at increase risk for malignancy, it is important that this entity be considered in the differential diagnosis. The observations in this case indicate that it is difficult to diagnose JP only by cytology, but the combination of clinical findings—a well-circumscribed mass in a young patient with cystic fluid, but with a residual mass after aspiration due to the multicystic nature of JP—with the cytologic findings—sheets of hyperplatic breast epithelium with areas resembling fibroadenoma, macrophages, and apocrine cells—that appear to be sufficiently characteristic to suggest the diagnosis of JP. 相似文献
15.
Louis Journeau Marc-Antoine Pistorius Ulrique Michon-Pasturel Marc Lambert Francois-Xavier Lapébie Alessandra Bura-Riviere Philippe de Faucal Patrick Jego Quentin Didier Cécile Durant Geoffrey Urbanski Baptiste Hervier Claire Toquet Christian Agard Olivier Espitia 《Autoimmunity reviews》2019,18(5):476-483
16.
Guido Monga Gianna Mazzucco Francesco Paolo Rossini Franco Presti 《Virchows Archiv : an international journal of pathology》1979,382(3):355-360
Summary An unusual form of colorectal polyposis is described displaying juvenile, adenomatous and mixed patterns in a 17-year-old girl. Although juvenile polyposis is generally considered to be non-neoplastic in nature, in both the present and in other case reports histological findings support a neoplastic nature. Since an increase in the incidence of large bowel carcinomas has been found in subjects with a previous diagnosis of juvenile polyposis, these patients should be considered to be at risk, and submitted to follow up. 相似文献
17.
Analysis of depressed cell-mediated immunity in asbestos workers 总被引:1,自引:0,他引:1
R D deShazo J Nordberg Y Baser B Bozelka H Weill J Salvaggio 《The Journal of allergy and clinical immunology》1983,71(4):418-424
To explore the mechanisms of asbestos-related perturbations of the immune system, we evaluated the in vitro cell-mediated immunity of five asymptomatic asbestos workers with hypergammaglobulinemia and decreased T-cell numbers. These results were compared with those in 10 matched controls. Analysis of T-lymphocyte populations revealed decreased absolute numbers of OKT4+ (helper/inducer) T cells in the peripheral blood and phytohemagglutinin (PHA)-stimulated mononuclear cell cultures of the workers. When chrysotile asbestos was added to PHA cultures, expansion of OKT4+ cell populations was disproportionately inhibited in workers' cultures. Furthermore, control proliferative responses to PHA became indistinguishable from initial worker responses. These effects were incompletely explained by the cytotoxic effects of asbestos on cultured lymphocytes. We conclude that both in vivo and in vitro exposure of mononuclear cell populations to asbestos may lead to a diminution of helper-inducer T-cell numbers. In asbestos-exposed individuals, this latter lymphocyte subpopulation appears to be especially sensitive to in vitro asbestos exposure. Although the clinical implications of these findings are unclear, we hypothesize that many of the immunologic abnormalities that occur in asbestos workers could be explained by direct asbestos effects on the OKT4+ immunoregulatory population. 相似文献
18.
Summary A case of bilateral deep infrapatellar bursitis is reported in a 19-year-old man suffering from juvenile ankylosing spondylitis and surgically treated for bilateral tibial tuberosity enthesopathy. In addition to erosive nonspecific bone remodelling the excised specimens showed, in the bursa, synovial layer hyperplasia with mild subintimal inflammatory cell infiltration, i.e. changes similar to those of synovitis in ankylosing spondylitis. The respective roles of the inflammatory terrain and of local shearing stress are discussed. 相似文献
19.
We report the time-dependent magnetic resonance imaging (MRI) changes that resulted from an intramuscular injection of a commonly-used pediatric sedation regimen (DPT). These changes at the site of injection consist of a focal abnormality characterized by a slight increase in signal intensity on T1 weighted images and markedly increased signal intensity on T2 weighted images. Alterations in signal are detectable almost immediately after the injection and progress over the first 31 hours. This abnormality, which could be mistaken for real disease, persists up to 36 days following injection. 相似文献
20.