仰卧整复手法治疗颈椎病的临床观察

颈椎病为临床常见病,有研究显示,该病近年来有发病率升高和发病年龄提早的趋势。推拿疗法治疗该病具有一定疗效［１～３］,但也有因手法操作不当引起不良反应的报道［４～５］,需要进一步加强研究。本课题组自１９９２年开始,对“仰卧整复手法”治疗颈椎病的临床疗效进行了观察,现总结如下。１　临床资料诊断标准：参照第１、２届全国颈椎病专题座谈会纪要［１～８］和国家中医药管理局制定的“中医病证诊断疗效标准”［９］进行诊断。①临床表现与影像学所见相符;②具有典型的颈椎病临床表现,而影像学所见正常者,应在排除其他疾病…     

Species differences in inner ear fluids

Summary Inner ear fluids of guinea pigs and cats were analyzed for sodium, potassium, chloride, glucose, and total protein to determine species differences in chemical compositions. In the scala vestibuli perilymph and scala tympani perilymph, sodium, potassium, and choride levels in the guinea pig were lower than in the cat. The protein levels in the scala vestibuli perilymph and scala tympani perilymph of the guinea pig were lower than those of the cat. The glucose levels in the guinea pig were higher in the scala vestibuli perilymph and scala tympani perilymph, as compared to findings in the cat. Regarding the utricular endolymph, there were significant differences between guinea pigs and cats in sodium and potassium concentrations; the concentration in the former being higher in sodium and lower in potassium. These findings are pertinent for the phylogenetic studies on inner ear fluid biochemistry.This work was supported by Research Grant No. ROI-NS1026801 from the National Institute of Neurological Diseases and Strokes, USA     

Cross-tolerance in drug response and differential changes in central nicotinic and N-methyl-d-aspartate receptor binding following chronic treatment with either (+)- or (–)-nicotine

The present study compared the effects of chronic treatment (21 days) with (+)-nicotine and (–)-nicotine on exploratory behaviours and body temperature in rats. Chronic treatment with either (+)- or (–)-nicotine induced tolerance in exploratory behaviours. A cross-tolerance between the two stereoisomers was also observed. Body temperature was differentially affected by chronic (+)- and (–)-nicotine, but cross-tolerance was still observed. In addition, nicotinic acetylcholine receptor (nAChR) and N-methyl-d-aspartate (NMDA) receptor binding in rats treated with (+)- and (–)-nicotine were measured by receptor autoradiography. Chronic treatment with (+)- and (–)-nicotine significantly increased nAChR binding in different brain regions. Furthermore, significant differences in the induction of nAChR binding by chronic (+)- and (–)-nicotine were detected in several brain regions. Chronic treatment with (+)-nicotine significantly increased NMDA receptor binding in the CA1 region of the hippocampus. However, (–)-nicotine had no effect on NMDA receptor binding in any of the regions analysed. These results demonstrate differences between chronic treatment with (+)- and (–)-nicotine in physiological responses such as body temperature and biochemical changes such as changes in nAChRs and NMDA receptor binding, although a cross-tolerance between the two enantiomers in behaviour and body temperature is also observed. Received: 11 May 1999 / Final version: 26 August 1999     

试论在中医药院校增设《中医男科学》教学课程

阐述了中医男科学的地位、教学现状,进而分析在中医院校增设《中医男科学》的必要性、可行性。论述了中医男科学的范畴的内容。稳定中医男科学教学的基本措施和教学构想,为在中医院校开设中医男科学课程提出了较完整的思路。开设中医男科学是当今中医学术发展的必然和社会及临床实际的需要。     

腰椎后外侧融合术与后路椎体间融合术治疗腰椎滑脱的临床研究

目的研究腰椎后外侧融合术（PLF）与后路椎体间融合术（PLIF）治疗腰椎滑脱的临床效果。方法将2011年1月－2012年12月骨科收治的腰椎滑脱患者纳入研究,随机分为给予后外侧融合术的PLF组、经后路椎体融合术的PLIF组,观察手术相关指标、近期疗效情况及远期疗效情况。结果①二组患者术中出血量、术后引流量的差异无统计学意义,且PLIF组患者的手术时间低于对照组;②手术后,二组患者腰部疼痛评分低于手术前,椎间隙高度高于手术前,且PLIF组患者的腰部疼痛评分低于PLF组,椎间隙高度高于PLF组;③术后3,6,9,12个月时,PLIF组的ODI评分均低于PLF组。结论经后路椎间植骨融合术（PLIF）能够缩短手术时间、促进临床症状缓解、改善远期机体功能,并取得与后外侧融合术（PLF）相当的手术创伤。     

Body mass index and migraine: a survey of the Chinese adult population

The objective of this study is to evaluate the association between body mass index (BMI) and migraine in general population Chinese cohort. This was a cross-sectional secondary analysis from a general population Chinese cohort of men and women of reproductive and post-reproductive age ranging between 18 and 65 years. Migraine was defined utilizing ICHD criteria. Body mass indices were calculated using measured height and weight and categorized based on the World Health Organizations criteria. The 1-year period prevalence of migraine was 9.3 %. No association was identified between migraine and those with a BMI < 30.0. Compared to those with normal BMI (18.5–23.0), those with BMI ≥ 30 (morbid obesity) had a greater prevalence of migraine (8.6 vs. 13.8 %, p = 0.000). Multivariate-adjusted odds ratio demonstrated that those with morbid obesity had a greater than twofold increased odds of migraine [OR 2.10 (1.39–3.12)] as compared to those with a BMI between 18.5 and 23.0. No association was found between obesity and migraine severity, frequency, or disability. Morbid obesity was associated with twofold increased odds of migraine in this Chinese men and women cohort of predominantly reproductive age.     

不同时期脂肪肝患者体液免疫状态分析

目的 观察不同时期脂肪肝患者体液免疫水平的变化，揭示脂肪肝与体液免疫的关系。方法 应用免疫散射比浊法检测110例不同时期脂肪肝患者体液血清免疫球蛋白（Ig）及补体（C3）的含量。结果 单纯性脂肪肝组与对照组比，IgG、IgE明显升高。脂肪性肝炎组与对照组比，IgG、IgE、IgA均显著升高，IgM呈升高趋势。补体（C3）在单纯性组以及脂肪性肝炎组较对照组下降。结论 脂肪肝患者的体液免疫功能发生了改变，其异常程度可能与脂肪肝患者处于不同时期有关。     

糖尿病社区综合防治效果评价

[目的 ]　通过社区糖尿病综合防治 ,使糖尿病病人病情稳定 ,并发症减少 ,病人生活质量提高 ,医药费用降低。以此观察社区卫生服务在糖尿病综合防治中的实际效果。　 [方法 ]　对糖尿病人进行防治糖尿病健康教育 ,并饮食和运动的量化干预 ,建立科学的生活方式 ,纠正不良的生活习惯 ,控制可能导致糖尿病并发症发生的危险因素 ,配合必要的药物治疗。　 [结果 ]　综合管理 3个月 ,83例病人综合防治前后自身对照糖尿病防治知识及自我保健能力方面平均提高 89.16% (P <0 .0 1) ,纠正不良生活方式和不良生活习惯 79.3 2 % (P <0 .0 1) ,糖尿病自测率提高 71.0 8% (P <0 .0 1) ,体重平均下降 1.80kg(P <0 .0 1) ,腰围平均下降 1.77cm(P <0 .0 1) ,臀围平均下降 1.0 4cm(P <0 .0 1) ,体重指数 (BMI)平均下降 0 .68(P <0 .0 1) ,收缩压平均下降 11.19mmHg(P <0 .0 1) ,舒张压平均下降 5 .61mmHg(P <0 .0 1) ,空腹血糖平均下降 3 .3 3mmol/L(P <0 .0 1) ,餐后 2h血糖平均下降 3 .5 4mmol /L(P <0 .0 1) ,患者医药费用平均每人减少 97.0 5元。　 [结论 ]　社区卫生服务综合防治糖尿病 ,能提高疗效 ,提高患者的生活质量和降低医药费用     

Mild atopic dermatitis lacks systemic inflammation and shows reduced nonlesional skin abnormalities

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